Patents by Inventor Kevin L. Tays

Kevin L. Tays has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydroxamic acid derivatives
    Patent number: 5962521
    Abstract: The present invention relates to hydroxamic acid derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, to treat a glutamate abnormality and to treat a prostate disease in an animal.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: October 5, 1999
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Kevin L. Tays, Keith M. Maclin, Barbara S. Slusher
  • Certain sulfoxide and sulfone derivatives
    Patent number: 5902817
    Abstract: The present invention relates to thio derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, to treat a glutamate abnormality and to treat a prostate disease in an animal.
    Type: Grant
    Filed: April 9, 1997
    Date of Patent: May 11, 1999
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Kevin L. Tays, Keith M. Maclin, Barbara S. Slusher
  • Phosphoramidate derivatives
    Patent number: 5863536
    Abstract: The present invention includes phosphoramidate derivatives, compositions containing the same, and methods of using them as NAALADase inhibitors, particularly for the treatment of glutamate abnormalities and associated nervous tissue insult in a animal and for treatment of prostate disease and prostate cancer by inhibition of NAALADase enzyme.
    Type: Grant
    Filed: December 31, 1996
    Date of Patent: January 26, 1999
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Barbara S. Slusher, Kevin L. Tays, Keith M. Maclin
  • Inhibitors of NAALADase enzyme activity
    Patent number: 5795877
    Abstract: The present invention includes compounds, compositions, and methods of treatment for glutamate abnormalities and associated nervous tissue insult in a animal by inhibition of NAALADase enzyme. Compositions include phosphonate derivatives and mixtures thereof that inhibit NAALADase enzyme activity and their use for treating glutamate abnormalities such as created by global and focal ischemia and for treatment of prostate disease and prostate cancer by inhibition of NAALADase enzyme.
    Type: Grant
    Filed: December 31, 1996
    Date of Patent: August 18, 1998
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Barbara S. Slusher, Kevin L. Tays, Keith M. Maclin