Abstract: A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.

Abstract: A lighted architectural-structure covering is disclosed. In one example of an embodiment, an architectural-structure covering includes a light source arranged and configured to illuminate at least a portion of the architectural-structure covering. The architectural-structure covering may include first and second coverings. The light source is arranged and configured to direct light onto the second covering, which is arranged and configured to reflect, redistribute, etc. the received light toward the interior space of the room in which the architectural-structure covering is located. Thus arranged, the architectural-structure covering may be used to create, for example, diffused-lighting effects.

Abstract: A lighted architectural-structure covering is disclosed. In one example of an embodiment, an architectural-structure covering includes a light source arranged and configured to illuminate at least a portion of the architectural-structure covering. The architectural-structure covering may include first and second coverings. The light source is arranged and configured to direct light onto the second covering, which is arranged and configured to reflect, redistribute, etc. the received light toward the interior space of the room in which the architectural-structure covering is located. Thus arranged, the architectural-structure covering may be used to create, for example, diffused-lighting effects.

Abstract: A sampler apparatus for use in a well includes a housing having a full opening bore therethrough. A first removable sample chamber for trapping a well fluid sample is removably disposed in the housing in a location such as to avoid restricting the full opening bore regardless of whether the sample chamber is in an open or closed position. Preferably a plurality of such sample chambers are provided.

Abstract: A pressure limiter and pump for use in a testing string. The pressure limiter has an outer case and an inner mandrel which form an enclosure defining an annulus therebetween. The inlet and outlet check valves in the annulus define a pumping chamber therebetween which opens toward the pump. Fluid in the pumping chamber is never vented to the well annulus. In a first embodiment, a transversely mounted pressure limiter piston provides communication between the pumping chamber and a lower portion of the testing string when actuated. In the second and third embodiments, a pressure limiter piston is reciprocably disposed in the annulus between the case and mandrel; at a predetermined pressure differential, the pressure limiter piston reciprocates such that the volume in the pumping chamber is increased.

Abstract: A downhole inflatable packer pump for use in a testing string. The pump includes an upper mandrel rotatably disposed in a case. The upper mandrel includes a pump cam with a cam slot thereon. A piston cavity is defined between the case and inner mandrel in which a single, sleeve-type piston is reciprocably disposed. A cam roller on the piston engages the cam slot, and as the inner mandrel rotates, the piston is reciprocated. A diaphragm sealingly separates the piston chamber from a pumping chamber. Inlet and outlet check valves with annular resilient lips allow fluid flow into the pumping chamber from the well annulus and out of the pumping chamber into an outlet chamber in communication with the lower portion of the testing string. The piston chamber is filled with a lubricating oil, and pumping action of the reciprocating pump piston causes movement of the oil which is transmitted to the pumping chamber through the diaphragm.