Abstract: A medical device system includes an elongate sheath defining a lumen extending within the elongate sheath. A coupler mechanism is slidingly disposed within the lumen, the coupler mechanism including a proximal coupler and a distal coupler. An elongate member is secured to and extends proximally from the proximal coupler. An implantable medical device (IMD) is secured to and extends distally from the distal coupler. The distal coupler remains secured to the proximal coupler while the coupler mechanism remains within the lumen, and the distal coupler releases from the proximal coupler, thereby releasing the IMD, when the coupler mechanism is exterior to the lumen.

Abstract: Described herein are methods for treating rheumatoid arthritis by determining whether a subject having rheumatoid arthritis will respond to an anti-TNF-alpha therapy based on the number of innate and adaptive immune cells in a sample from the subject prior to treatment.

Abstract: A medical device system may include an elongate shaft having a lumen extending to a distal end of the elongate shaft, wherein a proximal portion of the elongate shaft is configured to disengage from a distal portion of the elongate shaft; a medical device disposed proximate the distal end of the elongate shaft; a release wire disposed within the lumen of the elongate shaft, wherein the release wire releasably attaches the medical device to the distal end of the elongate shaft; and an introducer sheath slidably disposed over the elongate shaft, wherein the introducer sheath is configured to disengage the proximal portion of the elongate shaft from the distal portion of the elongate shaft.

Abstract: Described herein are methods for treating rheumatoid arthritis by determining whether a subject having rheumatoid arthritis will respond to an anti-TNF-alpha therapy based on the number of innate and adaptive immune cells in a sample from the subject prior to treatment.

Abstract: A medical device system may include a sheath, a pusher wire, and a locking element. The sheath may have a first outer diameter adjacent to the proximal end and an enlarged outer diameter region having a second outer diameter greater than the first adjacent to the intermediate region. The pusher wire may be slidably disposed within a lumen of the sheath. The locking element may have a lumen extending therethrough. The locking element may have a first inner diameter adjacent to the distal end and a second inner diameter smaller than the first adjacent to the intermediate region. The locking element may configured to freely slide over a region of the sheath having the first diameter. When the locking element is disposed over the enlarged outer diameter region of the sheath having the second outer diameter, the locking element may be configured to depress the sheath radially inwards.

Abstract: A medical device system may include an elongate shaft having a lumen extending from a proximal end to a distal end, a release wire disposed within the lumen of the elongate shaft configured to releasably attach a medical device to the distal end of the elongate shaft, and a securement member releasably coupled to the proximal end of the elongate shaft and fixedly attached to a proximal end of the release wire. A proximal portion of the securement member may be configured to translate proximally away from the proximal end of the elongate shaft upon application of a proximally-directed force to the proximal portion of the securement member and radially inward directed force to the distal portion of the securement member while the elongate shaft is maintained in a fixed position.

Abstract: A medical device system may include an elongate shaft having a lumen extending from a proximal end to a distal end, a release wire disposed within the lumen of the elongate shaft configured to releasably attach a medical device to the distal end of the elongate shaft, and a securement member fixedly attached to the proximal end of the elongate shaft and to a proximal end of the release wire. A proximal portion of the securement member may be configured to translate proximally away from the proximal end of the elongate shaft upon application of a proximally-directed force to the proximal portion of the securement member while the elongate shaft is maintained in a fixed position, wherein the proximal portion remains connected to the proximal end of the elongate shaft after proximal translation away from the proximal end of the elongate shaft.

Abstract: A medical device system may include an elongate shaft having a lumen extending to a distal end of the elongate shaft, wherein a proximal portion of the elongate shaft is configured to disengage from a distal portion of the elongate shaft; a medical device disposed proximate the distal end of the elongate shaft; a release wire disposed within the lumen of the elongate shaft, wherein the release wire releasably attaches the medical device to the distal end of the elongate shaft; and an introducer sheath slidably disposed over the elongate shaft, wherein the introducer sheath is configured to disengage the proximal portion of the elongate shaft from the distal portion of the elongate shaft.

Abstract: A medical device system may include a sheath, a pusher wire, and a locking element. The pusher wire may be slidably disposed within a lumen of the sheath. The locking element may have a proximal end, a distal end, an intermediate region disposed between the proximal end and the distal end, and a lumen extending from the proximal end to the distal end. The locking element may have a first inner diameter adjacent to the distal end and a second inner diameter adjacent to the proximal end, the second inner diameter smaller than the first outer diameter. The distal end region of the locking element may be configured to freely slide over the sheath and when a proximal end region of the locking element is disposed over the sheath, the locking element may be configured to depress the sheath radially inwards.

Abstract: A medical device system may include a sheath, a pusher wire, and a locking element. The sheath may have a first outer diameter adjacent to the proximal end and an enlarged outer diameter region having a second outer diameter greater than the first adjacent to the intermediate region. The pusher wire may be slidably disposed within a lumen of the sheath. The locking element may have a lumen extending therethrough. The locking element may have a first inner diameter adjacent to the distal end and a second inner diameter smaller than the first adjacent to the intermediate region. The locking element may configured to freely slide over a region of the sheath having the first diameter. When the locking element is disposed over the enlarged outer diameter region of the sheath having the second outer diameter, the locking element may be configured to depress the sheath radially inwards.

Abstract: Described herein are methods for treating rheumatoid arthritis by determining whether a subject having rheumatoid arthritis will respond to an anti-TNF-alpha therapy based on the number of innate and adaptive immune cells in a sample from the subject prior to treatment.

Abstract: A medical device system may include an elongate shaft having a lumen extending from a proximal end to a distal end, a release wire disposed within the lumen of the elongate shaft configured to releasably attach a medical device to the distal end of the elongate shaft, and a securement member releasably coupled to the proximal end of the elongate shaft and fixedly attached to a proximal end of the release wire. A proximal portion of the securement member may be configured to translate proximally away from the proximal end of the elongate shaft upon application of a proximally-directed force to the proximal portion of the securement member and radially inward directed force to the distal portion of the securement member while the elongate shaft is maintained in a fixed position.

Abstract: A medical device system may include an elongate shaft having a lumen extending from a proximal end to a distal end, a release wire disposed within the lumen of the elongate shaft configured to releasably attach a medical device to the distal end of the elongate shaft, and a securement member fixedly attached to the proximal end of the elongate shaft and to a proximal end of the release wire. A proximal portion of the securement member may be configured to translate proximally away from the proximal end of the elongate shaft upon application of a proximally-directed force to the proximal portion of the securement member while the elongate shaft is maintained in a fixed position, wherein the proximal portion remains connected to the proximal end of the elongate shaft after proximal translation away from the proximal end of the elongate shaft.

Abstract: The present invention features methods of treating a subject having an autoimmune disease and/or inflammation including determining the genotype, and/or the glycophenotype of the subject and administering to the subject an Fc-activity modulating agent or an anti-TNF? agent based on the genotype and/or the glycophenotype of the subject. The invention also features methods of predicting the responsiveness of a patient to an anti-TNF? treatment by identifying a patient having inflammation or an autoimmune disease, determining the genotype, or glycophenotype of the subject, and selecting the patient for treatment with an Fc-activity modulating agent or an anti-TNF? agent based on the genotype and/or the glycophenotype of the subject.

Abstract: An approach for providing remote interaction (e.g., technical support) with electronic devices (e.g., mobile devices such as mobile phones, tablets, laptops, etc.) is provided. Specifically, remote control of a first electronic device may be obtained by an administrator device or the like. The first electronic device may then be remotely operated by the administrator device to view, indicate, and/or perform features/functions of a second electronic device needing technical support.

Abstract: An approach for providing remote interaction (e.g., technical support) with electronic devices (e.g., mobile devices such as mobile phones, tablets, laptops, etc.) is provided. Specifically, remote control of a first electronic device may be obtained by an administrator device or the like. The first electronic device may then be remotely operated by the administrator device to view, indicate, and/or perform features/functions of a second electronic device needing technical support.

Abstract: A method for determining a user intended number from a partial phone number includes steps for receiving a partial phone number, determining whether the partial phone number corresponds with at least one database number based on at least one selected criteria list and performing a system action based on the determination. The method may include prioritizing a list of database numbers that correspond to the partial number.

Abstract: A method, system and program of generating a chronicle of search terms used in a network environment of a community are provided. A term is received from a user in a current search. The term is matched in a search chronicle, wherein the search chronicle is a database comprising a plurality of search terms associated with a search originator. The search chronicle results are then provided to the user.

Abstract: A system and method is provided for masking traditional grey bars which are produced by displaying wide screen images within a full screen native projector and visa versa. This method allows blocking of light for unused portions of the screen thereby producing higher contrast images. In an exemplary embodiment, a physical shutter is positioned inside the projection system so that the light which would otherwise produce a grey bar area is blocked before it reaches a projection screen. Image data are analyzed to identify grey screen areas which are not being utilized for image display and light which would otherwise produce such grey areas is blocked or shuttered by the projector to eliminate the grey areas.

Abstract: The present invention provides privacy measures in instant messaging systems. A method in accordance with an embodiment of the present invention includes: setting a time-out value for a message; sending the message to a receiving user; and displaying the message to the receiving user only for a time period equal to the time-out value. In another embodiment, a stealth delivery mode is provided in which an IM message is displayed to the receiving user only if the receiving user has approved the display of the IM message. In a further embodiment, a predetermined number of elements received prior to a current IM message are displayed in the conversation pane of an IM client, based on a threshold value.