Abstract: Disclosed are systems that include a syringe having a barrel configured to hold a fluid and a plunger configured to draw the fluid into the barrel when the plunger is pulled backward through the barrel. The syringe is configured to inhibit forward movement of the plunger. For example, the systems can include mating pockets configured to engage barbs to inhibit forward movement of the plunger.

Abstract: A safety needle assembly includes a housing defining a cavity and having a button, a hub positioned in the cavity, and a needle connected with a distal face of the hub to extend out of the housing. The assembly includes a shield positioned in the cavity having a retracted mode in which the shield is retracted into the housing to expose the needle, and a securement mode in which the shield is extended over a distal end of the needle to cover the needle. A spring connects between the hub and the shield and is configured to transition the shield from the retracted mode to the securement mode. The assembly includes a lock-in mechanism configured to releasably maintain the shield in the retracted mode, and a lock-out mechanism configured to securely maintain the shield in the securement mode.

Abstract: A blood sequestration device includes an inlet path, an outlet path, a sequestration chamber, and a sampling channel. The sequestration chamber is connected with the inlet path by a junction and is configured to receive a first portion of blood through the inlet path. The sequestration chamber has a vent that allows air to be displaced by the first portion of blood, the junction being configured to inhibit a return to the inlet path of any of the first portion of blood received by the sequestration chamber. The sampling channel is connected between the inlet path and the outlet path, and configured to convey subsequent amounts of blood between the inlet path and the outlet path after the first amount of blood is received by the sequestration chamber.

Abstract: A bodily fluid collection system for collecting a bodily fluid from a patient, and a bodily fluid transfer system for transferring collected bodily fluid to a second collection device. A collection adapter has a connection port configured to securely connect with a hub of a syringe, and a collection interface opposite the connection port creates a fluid conduit to the barrel via the connection port and an inlet of the hub. A proximal adapter is connected to a proximal end of the fluid channel from the patient, and configured to removably interact with the collection interface of the collection adapter to connect the proximal end of the fluid channel to the barrel via the fluid conduit and inlet to the barrel to allow conveyance into the barrel of the at least some of the sampling portion of the sample of bodily fluid. The proximal adapter can be removed to allow access to any bodily fluid collected by the syringe.

Abstract: A fluid sample optimization device for optimizing a fluid sample collected by a fluid collection device from a fluid source, where a first portion of the fluid sample potentially has contaminants. The device includes an inlet configured to connect with the fluid source, an outlet configured to connect with the fluid collection device, a sample path connected between the inlet and the outlet, and a contaminant containment reservoir connected between the inlet and the outlet. The contaminant containment reservoir has an air permeable fluid resistor proximate the outlet, and is arranged to receive the first portion of the fluid sample from the fluid source to displace air therein, such that upon receipt of the first portion of the fluid sample and containment of the contaminants in the contaminant containment reservoir, subsequent portions of the fluid sample are conveyed by the sample path from the inlet to the outlet when subsequent pressure differentials are applied between the inlet and the outlet.

Abstract: A fluid sample optimization device for optimizing a fluid sample includes an inlet, an outlet, a sample path connected between the inlet and the outlet, and a contaminant containment reservoir connected between the inlet and the outlet. The contaminant containment reservoir includes an air permeable fluid resistor proximate the outlet, and is arranged to receive, when a pressure differential is applied between the inlet and the outlet, a first portion of the fluid sample to displace air therein through the air permeable fluid resistor and the outlet, such that upon receipt of the first portion of the fluid sample and containment of the contaminants in the contaminant containment reservoir, subsequent portions of the fluid sample can be conveyed by the sample path from the inlet to the outlet when subsequent pressure differentials are applied between the inlet and the outlet.

Abstract: A blood sequestration device includes an inlet path, an outlet path, a sequestration chamber, and a sampling channel. The sequestration chamber is connected with the inlet path by a junction and is configured to receive a first portion of blood through the inlet path. The sequestration chamber has a vent that allows air to be displaced by the first portion of blood, the junction being configured to inhibit a return to the inlet path of any of the first portion of blood received by the sequestration chamber. The sampling channel is connected between the inlet path and the outlet path, and configured to convey subsequent amounts of blood between the inlet path and the outlet path after the first amount of blood is received by the sequestration chamber.

Abstract: The flow rate of a gaseous sample of exhaled breath through an analytical device is controlled by a pump, and in certain embodiments two pumps. Placement of the analyte sensor in a secondary stream branching off of the primary stream through the device offers further control over the manner, duration, and quantity of the breath that is placed in contact with the sensor.

Abstract: The flow rate of a gaseous sample of exhaled breath through an analytical device is controlled by a pump, and in certain embodiments two pumps. Placement of the analyte sensor in a secondary stream branching off of the primary stream through the device offers further control over the manner, duration, and quantity of the breath that is placed in contact with the sensor.

Abstract: A device, system and method for diagnosing and treating gastric disorders is provided. A submucosal gastric implant device is placed within the submucosal layer of a patient's stomach wall. The device in one embodiment provides electrical stimulation of the stomach wall and may use multiple electrode pairs for sequential stimulation. The device may also have other functional aspects such as a sensor for sensing various parameters of the stomach or stomach environment, or a therapeutic delivery device. The implant may be programmed to respond to sensed information or signals. The device may be modular with a portion of the device accessible outside the stomach wall for removal and replacement. An endoscopic delivery system prepares and delivers the functional device through the esophagus and into the stomach where it is placed through an opening in the mucosa into the submucosal layer of the stomach wall.

Abstract: A device, system and method for diagnosing and treating gastric disorders is provided. A submucosal gastric implant device is placed within the submucosal layer of a patient's stomach wall. The device in one embodiment provides electrical stimulation of the stomach wall and may use multiple electrode pairs for sequential stimulation. The device may also have other functional aspects such as a sensor for sensing various parameters of the stomach or stomach environment, or a therapeutic delivery device. The implant may be programmed to respond to sensed information or signals. The device may be modular with a portion of the device accessible outside the stomach wall for removal and replacement. An endoscopic delivery system prepares and delivers the functional device through the esophagus and into the stomach where it is placed through an opening in the mucosa into the submucosal layer of the stomach wall.

Abstract: The flow rate of a gaseous sample of exhaled breath through an analytical device is controlled by a pump, and in certain embodiments two pumps. Placement of the analyte sensor in a secondary stream branching off of the primary stream through the device offers further control over the manner, duration, and quantity of the breath that is placed in contact with the sensor.

Abstract: The flow rate of a gaseous sample of exhaled breath through an analytical device is controlled by a pump, and in certain embodiments two pumps. Placement of the analyte sensor in a secondary stream branching off of the primary stream through the device offers further control over the manner, duration, and quantity of the breath that is placed in contact with the sensor.

Abstract: The present invention is a disposable sensor for use with a device that quantifies analytes in a gaseous sample. It comprises (i) a sensing element, (ii) a means for interfacing the disposable sensor with a gas analysis device, and (iii) a housing. When used with a device that can quantify the concentration of an analyte in a gas sample, the present invention facilitates the use of exhaled breath analysis as a clinical tool.

Abstract: The present invention is a disposable sensor for use with a device that quantifies analytes in a gaseous sample. It comprises (i) a sensing element, (ii) a means for interfacing the disposable sensor with a gas analysis device, and (iii) a housing. When used with a device that can quantify the concentration of an analyte in a gas sample, the present invention facilitates the use of exhaled breath analysis as a clinical tool.

Abstract: The present invention is a disposable sensor for use with a device that quantifies analytes in a gaseous sample. It comprises (i) a sensing element, (ii) a means for interfacing the disposable sensor with a gas analysis device, and (iii) a housing. When used with a device that can quantify the concentration of an analyte in a gas sample, the present invention facilitates the use of exhaled breath analysis as a clinical tool.

Abstract: A device, system and method for diagnosing and treating a patient is provided where a functional device is attached to a stomach wall. The device in one embodiment provides electrical stimulation of the stomach wall. The device may also have other functional aspects such as a sensor for sensing various parameters of the stomach or stomach environment, or a substance delivery device. The implant may be programmed to respond to sensed information or signals. The device may be modular with a portion of the device accessible for removal and replacement. In one embodiment, an endoscopic delivery system delivers the functional device through the esophagus and into the stomach where it is attached the stomach wall with the assistance of a suction used to stabilize the tissue of the stomach wall. The device includes a chamber for receiving tissue of the stomach wall for attachment where a vacuum pressure is applied through the chamber to draw the tissue into the chamber.

Abstract: The present invention is a system and method of conditioning the sample and surrounding environment of an exhaled breath sensor. It includes (i) using a particular molecular sieve for a triple purpose: (a) maintaining the sensor at a constant relative humidity during storage, (b) equilibrating the incoming breath stream to the same relative humidity as the sensor, and (c) eliminating the analyte from the environment around the sensor during storage. The present invention also includes removal of interfering components from the exhaled breath, such as carbon dioxide, as well as a thermal management technique.

Abstract: A device, system and method for diagnosing and treating a patient is provided where a functional device is attached to a stomach wall. The device in one embodiment provides electrical stimulation of the stomach wall. The device may also have other functional aspects such as a sensor for sensing various parameters of the stomach or stomach environment, or a substance delivery device. The implant may be programmed to respond to sensed information or signals. The device may be modular with a portion of the device accessible for removal and replacement. In one embodiment, an endoscopic delivery system delivers the functional device through the esophagus and into the stomach where it is attached the stomach wall with the assistance of a suction used to stabilize the tissue of the stomach wall. The device includes a chamber for receiving tissue of the stomach wall for attachment where a vacuum pressure is applied through the chamber to draw the tissue into the chamber.

Abstract: The present invention is a disposable sensor for use with a device that quantifies analytes in a gaseous sample. It comprises (i) a sensing element, (ii) a means for interfacing the disposable sensor with a gas analysis device, and (iii) a housing. When used with a device that can quantify the concentration of an analyte in a gas sample, the present invention facilitates the use of exhaled breath analysis as a clinical tool.