Abstract: Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: Provided are small molecule inhibitors of the KRAS(G12D) mutant oncoprotein having the structural formula: and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: Provided are compounds of Formula: H-L-T and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: Provided are small molecule inhibitors of the KRAS(G12D) mutant oncoprotein having the structural formula: R00F2C—L—R0 and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: Methods for treating cancer in a subject, comprising administering to the subject an effective amount of a compound represented by the following structural formula a tautomer, or a pharmaceutically acceptable salt thereof in combination with radiotherapy. The variables depicted in the structural formula are defined herein.

Abstract: Methods for treating a subject with cancer mediated through dysregulated, aberrant, or defective JAK/STAT signaling, are provided, comprising determining the level of the JAK/STAT signaling in a sample derived from a subject in need of treatment, wherein the presence of dysregulated, aberrant, or defective JAK/STAT signaling is indicated, administering to the subject an effective amount of a triazolone compound as described herein.

Abstract: Novel mammalian Ztgf?-9 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.

Abstract: Novel mammalian Ztgf&bgr;-9 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.

Abstract: A method for treating psoriasis. An antagonist to IL-17D&bgr;9 (IL-17D) is administered to treat psoriasis. The antagonist can be an antibody that binds to IL-17D&bgr;9 or its receptor or a soluble receptor that binds to IL-17D&bgr;9 or a membrane-spanning protein-5 (MSP-5).

Abstract: Semaphorin polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptide is expressed in breast cancer, and neuronal tissues. The polypeptides, and polynucleotides encoding them, may be used for detecting human chromosomal abnormalities and cancers. The polypeptides may be used within methods for detecting receptors that mediate neurite outgrowth, modulate cellular proliferation and/or differentiation, and immune response. The present invention also includes antibodies to the ZSMF-16 polypeptides and uses therefore.

Abstract: A stethoscope having a monophonic electrical sensor which feeds electrical signals corresponding to heart sounds to a transversal filter to produce pseudostereophonic signals at split outputs which may be used to power dual earphones for binaural listening. The electronic processing of the heart sounds in the transversal filter enables the listener to differentiate the different sounds of the heart.