Abstract: An electrosurgical instrument comprising a housing, a shaft extending from the housing, an end effector extending from the shaft, an articulation joint rotatably connecting the end effector to the shaft, and a wiring circuit is disclosed. The housing comprises a printed control board. The wiring circuit extends from the printed control board through the shaft and into the end effector. The wiring circuit is configured to monitor a function of the end effector and communicate the monitored function to the printed control board. The wiring circuit comprises a proximal rigid portion fixed to the shaft, a distal rigid portion fixed to the end effector, and an intermediate portion extending from the proximal rigid portion to the distal rigid portion. The intermediate portion comprises a resilient portion and a stretchable portion.

Abstract: Provided are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2A, R2B, R3, R4, and R5 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A method for performing an electrosurgical procedure using an electrosurgical instrument including an end effector is disclosed. The method comprises applying a bipolar energy to a target tissue grasped by the end effector in a tissue-feathering segment, applying an energy blend of the bipolar energy and a monopolar energy to the target tissue in a tissue-warming segment and a tissue-sealing segment following the tissue-warming segment, and discontinuing the bipolar energy but continuing to apply the monopolar energy to the target tissue in a tissue-cutting segment following the tissue-sealing segment.

Abstract: A leakproof plastic zipper with integrated end stops for a zipper slider particularly suited for thermoplastic bags. An increased flange height above the interlocking elements of the zipper and an increased plow depth on the separator of the slider extending down between the flanges provide a means of stopping the travel of the slider past the ends of the zipper. The separator structure depending from the slider has a configuration in vertical cross-section corresponding to an inverted T, the horizontal portion of the T having the ends thereof adapted to be received in window structure in the flanges above the interlocking elements and adjacent one of the integrated end stops.

Abstract: A multilayer film is hermetically heat sealable over a broad temperature range. In one embodiment, a heat sealable layer is provided to a polypropylene core layer. The heat sealable layer comprises an ethylene-propylene copolymer and/or an ethylene-propylene-butene terpolymer with an inorganic antiblock agent having a particle size of at least 0.8 micron and at least about 1000 ppm of a fatty acid amide, the layer having a thickness of at least about 10-25% of the total film thickness. A metal-receiving layer may be provided to a surface of the core layer opposite the heat-sealable layer and the film may be metallized.