Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.

Abstract: Provided herein are RET kinase inhibitors according to the formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.

Abstract: The invention pertains to the field of sugar cane. More particularly, the invention pertains to efficiently utilizing a sugar cane product for multiple accessory items (i.e. shot glass, drinking glass, straw, stirrer, decorative element, etc.). The sugar cane accessory item includes a stalk of sugar cane that is billeted and utilized as a food accessory item, wherein the sugar cane stalk may include at least one opening extending within the billeted section of sugar cane if utilized as a shot glass, drinking glass and/or straw. The stalk may also be billeted and comprised of a solid structure to be utilized as a pair of chopsticks, a stirrer, a shish kabob utensil or various other food accessory items. A method of manufacturing the sugar cane accessory item is also disclosed.

Abstract: A shaped sugar cane product for use as chopsticks, garnish sticks, stir sticks and snack sticks is made from sugar cane stalks. The method comprises billeting the stalks into desired lengths for the sticks, and then pressing the billets lengthwise against a cutter comprising a grid of intersecting cutting blades to produce finished sticks.

Abstract: Disclosed is a flour-type product derived from sugar cane which contains a high dietary fiber concentration. This product is made by separating the pith of the sugar cane from the rind and epidermal layer and then removing from the pith any rind residue from a first stage separation and long fibrovascular bundles embedded in the parenchyma cells of the pith. The clean pith is dried and milled to shred the walls of the parenchyma cells into fiber having a length not exceeding 300 microns.