Abstract: Provided herein are protective laminate devices comprising a biocompatible non-adherent substance and a fast-setting adhesive and methods of use. Also provided is a dispenser for an adhesive tape. The protective laminate devices and methods may be used for wound closure.

Abstract: Provided herein are protective laminate devices comprising a biocompatible non-adherent substance and a fast-setting adhesive and methods of use. Also provided is a dispenser for an adhesive tape. The protective laminate devices and methods may be used for wound closure.

Abstract: Provided herein is a device for controlling the release of a substance at a site of interest in a biological membrane comprising a means of monitoring a physiological state at the site of interest; and a means of releasing a variable amount of the substance to the site of interest where the amount varies in response to the status of the monitored physiological state. Also provided are methods of using the device.

Abstract: Provided herein is a device for use in an anastomosis of tissue(s) comprising a biocompatible material and a means of applying radiofrequency energy or electrical energy to generate heat within said biocompatible material. The device also may be used to bond or fuse at two materials where at least one of the material is a tissue. Also provided are methods to anastomose tissue or to bond or to fuse these materials using these devices.

Abstract: Provided herein is a device for fusing at least two materials, of which at least one material is a tissue, with an inductively fusable biocompatible material having therewithin a means for controlling output of heat generated therein by the oscillating magnetic field induced by at least one induction coil to which radiofrequency energy is applied. Also provided is a method for fusing the at least two materials using this device.

Abstract: Provided herein is a device for controlling the release of a substance at a site of interest in a biological membrane comprising a means of monitoring a physiological state at the site of interest; and a means of releasing a variable amount of the substance to the site of interest where the amount varies in response to the status of the monitored physiological state. Also provided are methods of using the device.

Abstract: Provided herein is a device for use in an anastomosis of tissue(s) comprising a biocompatible material and a means of applying radiofrequency energy or electrical energy to generate heat within said biocompatible material. The device also may be used to bond or fuse at two materials where at least one of the material is a tissue. Also provided are methods to anastomose tissue or to bond or to fuse these materials using these devices.

Abstract: Provided herein is a device for altering a biological membrane in an individual comprising a means for delivering energy to the surface of the biological membrane, a means for monitoring a physiological state of the biological membrane during delivery of said energy, a means for modulating delivery of the energy to the biological membrane where the modulating is in response to a change in the monitored physiological state. Also provided is a device to control the permeation of substance across a biological membrane and methods for use of these devices.

Abstract: The present invention provides a drug-delivery patch having at least one dissolvable layer comprising an active material and an adhesive backing or cover. The present invention also provides a method of transdermally vaccinating an animal by ablating an area of the stratum corneum of the animal and applying the patch described herein to the area.

Abstract: The present invention improves the cosmetic appearance of skin by controllably heating a superficial layer of skin thereby inducing acute tissue contraction or shrinkage and a wound response leading to the production of biomolecules, all of which result in improved cosmesis. The invention incorporates a source of radiofrequency electrical energy coupled to coil, with requisite impedance matching network, thereby resulting in the production of an alternating magnetic field. When tissue is brought into proximity of the alternating magnetic field, inductive heating of the tissue results as a consequence of either or both of dipole formation and oscillation, and eddy current formation. Optionally, cooling is provided to remove heat from the coil, the source of radiofrequency electrical energy, or the surface of the skin alone or in combination.

Abstract: The present invention provides a catheter device/method for enhancing local administration of pharmaceutical compounds. Such device/method is used for various situations which require high concentrations of drugs that are delivered locally.

Abstract: The present invention provides various methods/systems of optical imaging of subsurface anatomical structures and biomolecules utilizing red and infrared radiant energy. Also provided are various applications of such methods/systems in medical diagnosis and treatment.

Abstract: Provided herein are devices and methods for altering a tissue in an individual. The device comprises an applicator having a surface to contact the tissue, a means to drive the applicator and, optionally, an abrasive material. The devices can further comprise a means to monitor a physical property, such as an electrical property, of the tissue with feedback control. The devices and methods may be used to partially or completely ablate the skin or other tissue in an individual for the purpose of enhancing the delivery of a therapeutic or diagnostic material or molecule or to improve cosmesis.

Abstract: The present invention relates to methods, devices for using electromagnetic energy to inductively alter biomolecular targets for therapeutic or diagnostic purposes. The biomolecular targets optionally may be a composition comprising groups or “sinks” linked to them in order to enhance the magnitude of interaction between the target and the electromagnetic energy.

Abstract: Provided herein are methods, devices and compositions to conductively or to inductively fix substrates, including tissues, using electromagnetic energy. Also provided is a method of controlling the fixing process via feedback monitoring of a property of the composition and/or of the electromagnetic energy used.

Abstract: The present invention provides methods, devices and systems for increasing the energy of biologically active molecules in vitro or in vivo by utilizing electromagnetic energy, inductively-applied electromagnetic energy or magnetic energy. Such methods, devices and systems also can be used for inducing or accelerating the rate of a reaction by increasing energy of the reactants.

Abstract: Provided herein are methods, devices and compositions to conductively or to inductively heat substrates using electromagnetic energy. Also provided are methods, devices and compositions to inductively alter or treat a substrate by inducing a conformational change in the compositions and/or the substrates. The compositions provided comprise an energy absorbing species to transduce heat to the substrates to effect such alterations or treatments.

Abstract: The present invention provides an improved method of measuring analytes in body fluids without the use of a sharp. The method having the steps of irradiating the skin of a patient by focused pulses of electromagnetic energy emitted by a laser. By proper selection of wavelength, energy fluence, pulse temporal width and irradiation spot size, the pulses precisely irradiate the skin to a selectable depth, without causing clinically relevant damage to healthy portions of the skin. After irradiation, interstitial fluid is collected into a container or left on the skin. The interstitial fluid is then tested for a desired analyte to approximate the analyte concentration in other body fluids. Alternatively, after the forced formation of a microblister, the epidermis covering the microblister is lysed and the interstitial fluid is subsequently collected and tested.

Abstract: The present invention provides a method/device for enhancing a chemical reaction including PCR and ELISA by utilizing electromagnetic or mechanical energy. Such method/device can also be used for increasing the rate at which a group of molecules reaches a different molecular configuration from initial configuration, thereby increasing binding and reacting of the molecules.

Abstract: Provided herein is a device for altering a tissue in an individual comprising an applicator, a means to drive the applicator, and an abrasive material. The devices can further comprise a control means to monitor a physical property of the tissue. Also, provided herein is a device for ablating skin in an individual. Additionally, methods to use these devices are provided.