Patents by Inventor Kevin Shao-Kwan Lee
Kevin Shao-Kwan Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11725176Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.Type: GrantFiled: August 29, 2022Date of Patent: August 15, 2023Assignees: Sanofi, Massachusetts Institute Of TechnologyInventors: Shireen Goh, Rajeev Jagga Ram, Kevin Shao-Kwan Lee, Michelangelo Canzoneri, Horst Blum
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Publication number: 20220411741Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.Type: ApplicationFiled: August 29, 2022Publication date: December 29, 2022Applicants: Sanofi, Massachusetts Institute of TechnologyInventors: Shireen Goh, Rajeev Jagga Ram, Kevin Shao-Kwan Lee, Michelangelo Canzoneri, Horst Blum
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Patent number: 11459538Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.Type: GrantFiled: October 16, 2019Date of Patent: October 4, 2022Assignees: Sanofi, Massachusetts Institute of TechnologyInventors: Shireen Goh, Rajeev Jagga Ram, Kevin Shao-Kwan Lee, Michelangelo Canzoneri, Horst Blum
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Publication number: 20210048408Abstract: Methods of calibrating a pH sensor fixed within an enclosed vessel are disclosed. The methods include introducing a buffer into the enclosed vessel, introducing a gas mixture comprising CO2 into the enclosed vessel, measuring a pH signal of the solution, measuring a CO2 concentration of a headspace gas of the solution, and calculating a pH value with a buffer calibration curve. The methods include calculating a calibration parameter with a sensor calibration curve and calibrating the pH sensor with the calibration parameter. Reactor systems are also disclosed. The systems include an enclosed reactor, a pH sensor, a CO2 sensor, a temperature control subsystem, and a controller. Methods of facilitating pH sensor calibration without sampling in a bioreactor system are also disclosed. The methods include providing a controller and providing instructions to operably connect the controller to the pH sensor and the CO2 sensor.Type: ApplicationFiled: August 12, 2020Publication date: February 18, 2021Inventors: Harry Lee, Kevin Shao-Kwan Lee
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Publication number: 20200040298Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.Type: ApplicationFiled: October 16, 2019Publication date: February 6, 2020Inventors: Shireen Goh, Rajeev Jagga Ram, Kevin Shao-Kwan Lee, Michelangelo Canzoneri, Horst Blum
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Patent number: 10472602Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.Type: GrantFiled: October 25, 2013Date of Patent: November 12, 2019Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, SanofiInventors: Shireen Goh, Rajeev Jagga Ram, Kevin Shao-Kwan Lee, Michelangelo Canzoneri, Horst Blum
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Patent number: 9574167Abstract: A microreactor with a reaction chamber comprising two sub-chambers with reconfigurable volumes, an input conduit with input valve, an un-filtered output conduit with first output valve, and a filtered output conduit with a second output valve is used to perform a method to control a different dilution rate for cells and molecules in continuous culture bioprocesses. In preferred embodiments flow control is achieved using the difference in volume of the two sub-chambers.Type: GrantFiled: February 14, 2014Date of Patent: February 21, 2017Assignee: Pharyx, Inc.Inventors: Harry Lee, Kevin Shao-Kwan Lee
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Patent number: 9328962Abstract: The present invention provides apparatus and methods to operate microreactor devices through the controlled delivery of pressurized fluids. A heated reservoir, a heated manifold, and a heater for the microreactor device provides for the delivery of a pressurized gas while minimizing evaporation and condensation; and a fluid interface and pressure interlock provides for the delivery of aseptic fluids while minimizing contamination and fluid loss.Type: GrantFiled: January 25, 2013Date of Patent: May 3, 2016Assignee: Pharyx, Inc.Inventors: Harry Lee, Kevin Shao-Kwan Lee
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Patent number: 9176060Abstract: The present invention provides apparatus and methods for measuring the optical density of a fluid by measuring the light transmission through a reconfigurable optical path. The optical path is reconfigured by the deflection of an elastic membrane wherein the optical path length through the fluid is determined by the position of the membrane relative to a fixed surface. The optical density can be determined from two measurements with different optical path lengths through the fluid.Type: GrantFiled: April 9, 2012Date of Patent: November 3, 2015Assignee: Pharyx, Inc.Inventors: Harry Lee, Kevin Shao-Kwan Lee
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Publication number: 20150132845Abstract: Devices, systems, and methods for continuous cell culture and other reactions are generally described. In some embodiments, chambers (e.g., cell growth chambers) including at least a portion of a wall formed of a flexible member are provided. A retaining structure can be incorporated outside and proximate to the chamber such that when liquid is added to the chamber, the flexible member is consistently and predictably deformed, and a consistent volume of liquid is added. The flexible member can be formed of, in some embodiments, a gas-permeable medium. In some embodiments, reaction chambers can be arranged in a fluidic loop, and a bypass channel can be used to introduce and/or extract fluid from the loop without affecting loop operation.Type: ApplicationFiled: November 6, 2014Publication date: May 14, 2015Applicant: Massachusetts Institute of TechnologyInventors: Rajeev Jagga Ram, Kevin Shao-Kwan Lee
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Publication number: 20140234954Abstract: A microreactor with a reaction chamber comprising two sub-chambers with reconfigurable volumes, an input conduit with input valve, an un-filtered output conduit with first output valve, and a filtered output conduit with a second output valve is used to perform a method to control a different dilution rate for cells and molecules in continuous culture bioprocesses. In preferred embodiments flow control is achieved using the difference in volume of the two sub-chambers.Type: ApplicationFiled: February 14, 2014Publication date: August 21, 2014Applicant: Pharyx, IncInventors: Harry Lee, Kevin Shao-Kwan Lee
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Publication number: 20140120609Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.Type: ApplicationFiled: October 25, 2013Publication date: May 1, 2014Applicants: Sanofi, Massachusetts Institute of TechnologyInventors: Shireen Goh, Rajeev Jagga Ram, Kevin Shao-Kwan Lee, Michelangelo Canzoneri, Horst Blum
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Publication number: 20130084622Abstract: Devices, systems, and methods for continuous cell culture and other reactions are generally described. In some embodiments, chambers (e.g., cell growth chambers) including at least a portion of a wall formed of a flexible member are provided. A retaining structure can be incorporated outside and proximate to the chamber such that when liquid is added to the chamber, the flexible member is consistently and predictably deformed, and a consistent volume of liquid is added. The flexible member can be formed of, in some embodiments, a gas-permeable medium. In some embodiments, reaction chambers can be arranged in a fluidic loop, and a bypass channel can be used to introduce and/or extract fluid from the loop without affecting loop operation.Type: ApplicationFiled: September 30, 2011Publication date: April 4, 2013Applicant: Massachusetts Institute of TechnologyInventors: Rajeev Jagga Ram, Kevin Shao-Kwan Lee
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Publication number: 20090220935Abstract: Parallel, integrated bioreactor. The bioreactor includes a plurality of growth chambers, each growth chamber associated with a peristaltic oxygenating mixer and separated therefrom by a porous membrane. Each oxygenating mixture has a gas inlet and a gas outlet with the gas inlet in fluid communication with a gas reservoir. A gas mixer switch is provided for controlling oxygen concentration in the reservoir. The apparatus and methods disclosed in the application allow precise control over dissolved oxygen concentration with a quick response time.Type: ApplicationFiled: March 9, 2007Publication date: September 3, 2009Applicant: Massachusetts Instutite of TechnologyInventors: Harry Lee, Kevin Shao-Kwan Lee