Abstract: Described herein are compositions and formulations to treat and/or prevent a PI3K mediated disease or a symptom thereof in a subject in need thereof. In some embodiments, such compositions include engineered peptides capable of targeting PI3K or Connexin 43. Also described herein are methods of treating and/or preventing PI3K mediated disease or a symptom thereof. In some embodiments, the PI3K mediated disease is a cancer.

Abstract: Described herein are compositions, methods, and techniques to generate a cancer signature and uses thereof. The cancer signature can be used to determine a cancer progression risk of a subject based upon expression levels of genes of a progression gene signature in a sample. The methods can be used to predict a prognosis, to select an appropriate treatment regimen, to identify or screen for an agent effective against a cancer, or a combination thereof. Computer implemented methods and systems that implement those methods are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: An apparatus comprises a plurality of transceiver circuits, a memory, and an interface circuit. The memory generally embodies a table associating a plurality of index values with corresponding gain and phase values for each channel of each of the transceiver circuits. In a first mode, the interface circuit may be configured to receive the corresponding gain and phase values associated with each of the plurality of index values and store the corresponding gain and phase values in the table. In a second mode, the interface circuit, in response to receiving one of the index values, configures each channel of each of the transceiver circuits with the corresponding gain and phase values from the table.

Abstract: A system for reducing maintenance frequency for bolts and nuts of a wind turbine comprises a plurality of fastening units, a PC data collector, a server and a terminal. The fastening unit has a bolt sequentially penetrates through a lower spacer, a sensor, an upper spacer, a wind turbine parts, a threaded ring, and a washer, and then a nut is engaged and tightly fastened on the bolt. With the fastening units, the system applied to the wind turbine is configured to create a double nut locking system thereby maintaining a preload tension force of the bolt in a safety operation range. Also, through the monitoring system including the sensor connected to the terminal through the PLC data collector and the server, a user can receive the real-time monitoring data of the preload tension force of the bolt to maintain and repair the wind turbine efficiently thereby preventing accidents.

Abstract: A counting mechanism of a hydraulic tightening device that includes an oil input/output mechanism and a counting mechanism, wherein the counting mechanism includes a counter, a piston sealing, a driving piston, a spring, a spring cover, a counting unit, a piston restricting unit, a main body seal, a lower cover, a bolt and a restricting unit. The oil input/output mechanism is connected to the hydraulic tightening device through the counting mechanism, and once the hydraulic oil passes through the oil input/output mechanism, the counting mechanism automatically records as the hydraulic tightening device performs one more time.

Abstract: According to one aspect there is disclosed an apparatus. The apparatus may include a first device.

Abstract: A monitoring circuit for monitoring a plurality of battery cells of a battery pack includes a plurality of temperature sensors, an analog to digital converter (ADC) and a processor. The plurality of temperature sensors is used for sensing temperatures of the plurality of battery cells and outputting a plurality of analog temperature voltage signals representative of the temperature of the plurality of battery cells. The analog to digital converter (ADC) is adapted to receive the plurality of analog temperature voltage signals and to convert each of the plurality of analog temperature voltage signals to a plurality of individual digital signals. The processor is adapted to generate an alert signal when an individual digital signal is not within a predetermined range.