Abstract: The invention relates to the diagnosis of a condition characterised by TDP-43 proteinopathy by mass spectrometry using one or more signature peptides of TDP-43 species.

Abstract: A biopsy device includes a body, a needle, a cutter, an analysis area, a valve, and a tissue sample holder. The cutter is movable relative to the needle and in communication with the needle for transporting tissue samples. The analysis area is disposed proximally of the cutter and in communication with the needle to receive a tissue sample cut by the cutter for analysis by a user. The valve is disposed proximally of the analysis area and configured to alternate between an open configuration and a closed configuration. The tissue sample holder is disposed proximally of the valve and fixedly attached to the body. The valve is configured to permit analysis of the sample disposed in the analysis area when the valve is in the closed configuration and to permit the tissue sample to be passed into the tissue sample holder when the valve is in the open configuration.

Abstract: An apparatus and method for securing objects to a transportation trailer wall. The apparatus comprises an elongate rigid member extending between first and second ends and a first E-Track connector at the first end of the elongate rigid member. The apparatus further comprises a second E-Track connector at the second end of the elongate rigid member and a collar slidably moveable along the elongate rigid member having a lock adapted to selectably lock the collar at a desired location therealong. The method comprises securing the apparatus to the trailer wall, locating at least one object to be secured between the elongate rigid member and the trailer wall, slideably positioning a collar along the elongate rigid member to secure the at least one object and engaging a lock on the collar to fix the location of the collar.

Abstract: A biopsy device includes a body, a needle, a cutter, an analysis area, a valve, and a tissue sample holder. The cutter is movable relative to the needle and in communication with the needle for transporting tissue samples. The analysis area is disposed proximally of the cutter and in communication with the needle to receive a tissue sample cut by the cutter for analysis by a user. The valve is disposed proximally of the analysis area and configured to alternate between an open configuration and a closed configuration. The tissue sample holder is disposed proximally of the valve and fixedly attached to the body. The valve is configured to permit analysis of the sample disposed in the analysis area when the valve is in the closed configuration and to permit the tissue sample to be passed into the tissue sample holder when the valve is in the open configuration configuration.

Abstract: An apparatus and method for for securing objects to a transportation trailer wall. The apparatus comprises an elongate rigid member extending between first and second ends and a first E-Track connector at the first end of the elongate rigid member. The apparatus further comprises a second E-Track connector at the second end of the elongate rigid member and a collar slidably moveable along the elongate rigid member having a lock adapted to selectably lock the collar at a desired location therealong. The method comprises securing the apparatus to the trailer wall, locating at least one object to be secured between the elongate rigid member and the trailer wall, slideably positioning a collar along the elongate rigid member to secure the at least one object and engaging a lock on the collar to fix the location of the collar.

Abstract: A biopsy device includes a body, a needle, a cutter, an analysis area, a valve, and a tissue sample holder. The cutter is movable relative to the needle and in communication with the needle for transporting tissue samples. The analysis area is disposed proximally of the cutter and in communication with the needle to receive a tissue sample cut by the cutter for analysis by a user. The valve is disposed proximally of the analysis area and configured to alternate between an open configuration and a closed configuration. The tissue sample holder is disposed proximally of the valve and fixedly attached to the body. The valve is configured to permit analysis of the sample disposed in the analysis area when the valve is in the closed configuration and to permit the tissue sample to be passed into the tissue sample holder when the valve is in the open configuration configuration.

Abstract: An MRI guided breast biopsy targeting set includes a firing obturator for use with positioning a breast biopsy device within a patient. The obturator is insertable into a targeting cannula in lieu of a needle of a biopsy device. The targeting set includes an obturator and a firing assembly. The firing assembly includes a housing, a latch mechanism, and a release mechanism, The firing assembly is responsive to the release mechanism to fire the obturator into the desired position within the breast.

Abstract: The present invention provides a method of managing shut down of a motor vehicle (100) comprising the steps of determining (S207) by means of a computing device that it is required to shut down the vehicle and, responsive to the determination that it is required to shut down the vehicle (PM=1), forcing shutdown of the vehicle (S212) by means of the computing device after a prescribed time period has elapsed (S211) if the motor vehicle has not shut down within the prescribed time period.

Abstract: The present invention provides a method of managing shut down of a motor vehicle (100) comprising the steps of determining (S207) by means of a computing device that it is required to shut down the vehicle and, responsive to the determination that it is required to shut down the vehicle (PM=1), forcing shutdown of the vehicle (S212) by means of the computing device after a prescribed time period has elapsed (S211) if the motor vehicle has not shut down within the prescribed time period.

Abstract: A door hinge includes a support plate, resilient fingers, and a hinge-pin cylinder. The support plate includes first and second edges, and the flexible fingers extend out from the first edge and curve toward the second edge at a distance spaced apart from the support plate. The hinge-pin cylinder is joined to the ends of the fingers to define a hinge line located inward from an outer edge of a door jamb to which the door is pivotally mounted.