Abstract: A pancreatic stent includes a main body convertible between a compressed configuration for delivery and an expanded configuration once deployed, the main body including an inner surface defining a stent lumen and an outer surface. A plurality of drainage features are formed within the outer surface of the main body, the plurality of drainage features permitting placement of the pancreatic stent within a patient's pancreas without blocking side branches of the pancreas.

Abstract: The present invention relates generally to a closure system for use in surgical procedures.

Abstract: An engine braking system includes engine braking actuators for adjusting exhaust valve timings to engine braking timings in a cylinder-number braking mode. The system further includes an engine braking controller coupled to a control switch that produces a request indicating a requested cylinder-number braking mode. The engine braking controller is structured to transition exhaust valves to the engine braking timings, determine a control term to adjust intake air pressure for varying a braking power of the engine, and to adjust geometry of an exhaust turbine based on the control term. An adjusted speed of a compressor rotated by the exhaust turbine provides a change to intake air pressure that adjusts the braking power of the engine. Different levels of braking power are provided within different cylinder-number braking modes.

Abstract: A system and method for evaluating a persistent bonus game jackpot includes providing a persistent bonus game jackpot including an amount that defines a state of the persistent bonus game jackpot, storing, within a memory, a plurality of paytables, each paytable of the plurality of paytables associated with a state of the persistent bonus game jackpot and including a probability of awarding the persistent bonus game jackpot at the associated state, determining a current state of the persistent bonus game jackpot, dynamically selecting, based upon the determined current state, a paytable from the plurality of paytables stored in the memory, evaluating a bingo card provided in association with the persistent bonus game jackpot against the dynamically selected paytable and a ball call, and determining, in response to the evaluating, to credit the amount of the persistent bonus game jackpot to a player credit balance associated with the evaluated bingo card.

Abstract: A system includes a set of crawlers that find and retrieve documents from an information network, an information extraction system, a knowledge graph storing nodes and edges that connect them, wherein each node represents a respective entity of a corresponding entity type of a plurality of entity types, and wherein the knowledge graph further stores event data relating to events detected by the information extraction system, a machine learning system that trains models that are used in connection with at least one of entity extraction, event extraction, recipient identification, and content generation, a lead scoring system that scores the relevance of information to an individual and references information in the knowledge graph, and a content generation system that generates content of a personalized message to a recipient who is an individual for which the lead scoring system has determined a threshold level of relevance.

Abstract: Medical devices and method for making and using the same are disclosed. An example medical device may include implantable medical device for use along the biliary and/or pancreatic tract. The implantable medical device may include a tubular member having a first end configured to be disposed within the duodenum of a patient and a second end configured to be disposed adjacent to a pancreatic duct and/or bile duct. The tubular member may have a body including one or more wire filaments that are woven together. The tubular member may also have an outer surface with a longitudinal channel formed therein.

Abstract: A pancreatic stent includes a main body convertible between a compressed configuration for delivery and an expanded configuration once deployed, the main body including an inner surface defining a stent lumen and an outer surface. A plurality of drainage features are formed within the outer surface of the main body, the plurality of drainage features permitting placement of the pancreatic stent within a patient's pancreas without blocking side branches of the pancreas.

Abstract: The present disclosure relates generally to dual-function medical devices with diagnostic and therapeutic capabilities, such as real-time visualization and ablation. Many embodiments may include an ergonomic handle and dual-lumen catheter configured for dual-function diagnostic and therapeutic use during a medical procedure, such as a duodenoscope. The medical device may be delivered within an endoscope working channel to provide real-time visualization (e.g., radial ultrasound imaging) and treatment (e.g., soft tissue ablation) of cancerous tissue. For instance, a first lumen may include a high-frequency linear or radial ultrasound and the second lumen may include a surgical instrument, such as an ablation tool. Some embodiments may include a controller with a feedback loop configured to adjust the therapeutic tool based on data from the diagnostic tool. For instance, the power of an ablation tool may be adjusted by the controller based on data generated by an imaging device.

Abstract: A system and method for evaluating a persistent bonus game jackpot includes providing a persistent bonus game jackpot including an amount that defines a state of the persistent bonus game jackpot, storing, within a memory, a plurality of paytables, each paytable of the plurality of paytables associated with a state of the persistent bonus game jackpot and including a probability of awarding the persistent bonus game jackpot at the associated state, determining a current state of the persistent bonus game jackpot, dynamically selecting, based upon the determined current state, a paytable from the plurality of paytables stored in the memory, evaluating a bingo card provided in association with the persistent bonus game jackpot against the dynamically selected paytable and a ball call, and determining, in response to the evaluating, to credit the amount of the persistent bonus game jackpot to a player credit balance associated with the evaluated bingo card.

Abstract: Medical devices and method for making and using the same are disclosed. An example medical device may include implantable medical device for use along the biliary and/or pancreatic tract. The implantable medical device may include a tubular member having a first end configured to be disposed within the duodenum of a patient and a second end configured to be disposed adjacent to a pancreatic duct and/or bile duct. The tubular member may have a body including one or more wire filaments that are woven together. The tubular member may also have an outer surface with a longitudinal channel formed therein.

Abstract: The present invention relates to an endoluminal device for implantation in a body lumen, such as a pancreatic duct. The device is provided with a distal end region having greater flexibility than that of a medial region of the device.

Abstract: An electronic gaming system includes a progressive system server configured to establish a tiered plurality of progressive jackpots that includes a first jackpot increasable a first cap value, a second jackpot increasable to a second cap value greater than the first cap value, and at least one intermediate jackpot increasable to at least one intermediate cap value greater than the first cap value and less than the second cap value. The progressive system server is further configured to allocate portions of player wagers to one of i) the first jackpot, ii) the at least one intermediate jackpot, and iii) the second jackpot, whereby the first jackpot is initially incrementally increased to the first cap value, the at least one intermediate jackpot is next incrementally increased to the at least one intermediate cap value, and the second jackpot is next incrementally increased to the second cap value.

Abstract: The present invention relates to an endoluminal device for implantation in a body lumen, such as a pancreatic duct. The device is provided with a distal end region having greater flexibility than that of a medial region of the device.

Abstract: An electronic gaming system includes a progressive system server configured to establish a tiered plurality of progressive jackpots that includes a first jackpot increasable a first cap value, a second jackpot increasable to a second cap value greater than the first cap value, and at least one intermediate jackpot increasable to at least one intermediate cap value greater than the first cap value and less than the second cap value. The progressive system server is further configured to allocate portions of player wagers to one of i) the first jackpot, ii) the at least one intermediate jackpot, and iii) the second jackpot, whereby the first jackpot is initially incrementally increased to the first cap value, the at least one intermediate jackpot is next incrementally increased to the at least one intermediate cap value, and the second jackpot is next incrementally increased to the second cap value.

Abstract: An introducer sheath for use in hybrid procedures on the heart includes a shaft having a distal balloon which is inflated inside the heart wall. A proximal collar is slidable along the shaft and locked to anchor the sheath to the wall of the heart. The sheath has markings visible to both the naked eye and under fluoroscopy to aid in judging the depth of insertion.

Abstract: The invention provides anti-OX40 antibodies and methods of using the same.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to modular assemblies, systems and methods for direct visualization and biopsy of peripheral pulmonary nodules. In one example, a modular assembly of the present disclosure may include a dual-lumen catheter attached to a distal end of a main body, a first lumen may extend through the main body, the first lumen contiguous with a first lumen of the dual-lumen catheter, a second lumen may extend through the main body, the second lumen contiguous with a second lumen of the dual-lumen catheter and an attachment member formed within the main body at a proximal end of the second lumen.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to an assembly with an adjustable ultrasound port and flush port for lateral and axial positioning of a radial ultrasound probe within a patient.

Abstract: The present disclosure relates generally to medical imaging devices, such as a real-time visualization and diagnostic and/or therapeutic tool assembly, which may include an ergonomic handle and catheter configured for dual-function use during a medical procedure. By way of non-limiting example, the medical device may be configured for use with a probe, such as one disposed at the distal end of the catheter, and delivered within a bronchoscope working channel to provide real-time visualization (e.g., radial ultrasound imaging) and manipulation (e.g., diagnostic biopsy sampling) of pulmonary nodules in peripheral regions of the lung. As disclosed herein, in various embodiments, one or more components of the medical imaging device may be configured to position a catheter with a first tool/instrument (e.g., a biopsy needle) within a peripheral region of the lung while maintaining real-time visualization of the pulmonary nodule (e.g., with a second tool/instrument, such as a radial ultrasound probe).

Abstract: An electrostatic transducer (100) comprises an electrically conductive backplane member (102) having an array of through apertures (112); a spacer member (104) disposed over the backplane member (102), the spacer member (104) having an array of holes (114) therethrough, the holes (114) each having a maximum lateral dimension less than twice a minimum lateral dimension; and a flexible electrically conductive membrane (106) disposed over the spacer member (104). The transducer (100) is arranged in use to apply an electrical potential which gives rise to an attractive electrostatic force between the backplane member (102) and the membrane (106) thereby moving portions of the membrane (106) spanning said holes in the spacer member (104) towards said backplane member (102).