Abstract: The present invention relates generally to the field of compositions for use in diagnostic methods. In particular, the present invention relates to a composition for use in a diagnostic method wherein the composition is a nutritional composition comprising 15-70 g fat, 60-90 g carbohydrates and 15-35 g protein. The diagnostic method may be a method to predict the risk of atheroma plaque presence in a subject.

Abstract: A device for cardiac valve repair, the device comprising: a stent adapted to anchor to at least one tissue site, the tissue site located upstream with respect to a heart valve of a patient; and a neo-leaflet arranged to extend from the upstream anchoring means, the neo-leaflet comprising a free end, wherein the neo-leaflet is operable to extend across the heart valve via a commissure in between two heart valve leaflets of the patient's heart and locate the free end downstream from the heart valve and the neo-leaflet operable to coapt with the heart valve leaflets of the patient's heart to prevent and/or minimize a backflow of blood. The present invention is suitable for the treatment of heart valves using minimally invasive approaches. Additionally, the present invention is directed to a method of implanting a device for cardiac valve repair in a patient's heart.

Abstract: A valve implant includes a valve leaflet prosthesis having a wire frame, a leaflet blade panel attached to the wire frame, and one or more tether struts extending from the wire frame, and a stent having a first end portion and a second end portion along a longitudinal stent axis, and a flexible extended stent strut extending longitudinally from the first end portion, wherein the one or more tether struts of the valve leaflet prosthesis is rotatably coupled to the flexible extended stent strut in a manner such that the one or more tether struts are rotatable about a rotational axis which is parallel to the one or more tether struts and which extends transverse to the longitudinal stent axis. A delivery system for the valve implant and a method of preparing the delivery system are also disclosed.

Abstract: The present invention relates to a device for cardiac valve repair, the device comprising: at least one upstream anchoring means adapted to anchor to at least one tissue site, the tissue site located upstream with respect to a heart valve of a patient; and a coaptation structure arranged to extend from the upstream anchoring means, the coaptation structure comprising a free end, wherein the coaptation structure is operable to extend across the heart valve and locate the free end downstream from the heart valve and the coaptation structure operable to coapt with at least one heart valve leaflet of the patient's heart to prevent and/or minimize a backflow of blood. The present invention is suitable for the treatment of heart valves using minimally invasive approaches. Additionally, the present invention is directed to a method of implanting a device for cardiac valve repair in a patient's heart.

Abstract: The present invention relates to a device for cardiac valve repair, the device comprising: at least one upstream anchoring means adapted to anchor to at least one tissue site, the tissue site located upstream with respect to a heart valve of a patient; and a coaptation structure arranged to extend from the upstream anchoring means, the coaptation structure comprising a free end, wherein the coaptation structure is operable to extend across the heart valve and locate the free end downstream from the heart valve and the coaptation structure operable to coapt with at least one heart valve leaflet of the patient's heart to prevent and/or minimize a backflow of blood. The present invention is suitable for the treatment of heart valves using minimally invasive approaches. Additionally, the present invention is directed to a method of implanting a device for cardiac valve repair in a patient's heart.