Abstract: Provided is a method for bonding panel of a microfluidic element by using a releasing film including preparing a panel having a pattern for a microfluidic channel formed on one surface thereof, preparing a release film coated with silicon nanoparticles on one or both surfaces thereof, plasma-treating one surface of the panel on which the pattern for the microfluidic channel is formed and the surface of the release film, and bonding the panel and the release film by performing heat treatment at a predetermined temperature range in a state in which the plasma-treated panel and the release film are attached to each other.

Abstract: Provided are an active droplet generating apparatus capable of controlling a droplet size, a method of controlling a droplet size using the same, and a self-diagnosis apparatus for diagnosing generation of a droplet, the active droplet generating apparatus including: a disposable microchannel upper plate; a multifunctional lower plate separated from the disposable microchannel upper plate and configured to be permanently used separately from the disposable microchannel upper plate; a functional polymeric film provided on a lower surface of the upper plate; a negative pressure forming means; and a flow velocity control device configured to adjust the droplet size to a desired size by receiving, by feedback, the voltage value measured by the droplet measuring electrode and controlling flow velocities of the oil and the sample, thereby controlling the droplet size in a feedback control manner by quickly and accurately measuring the droplet size using a capacitance impedance technique.

Abstract: Provided is a microfluidic device capable of removing microbubbles in a channel by using a porous thin film, the microfluidic device comprising: an upper panel comprising a microfluidic channel through which a fluid passes; a porous thin film attached to the bottom surface of the microfluidic channel so as to remove microbubbles included in the fluid that passes through the microfluidic channel; a lower panel contacting the bottom surface of the porous thin film and the upper panel, a path being provided in the lower panel so as to discharge microbubbles, which pass through the porous thin film, to the outside; and a vacuum-suctioning means for vacuum-suctioning the upper panel and the lower panel such that the microfluidic channel, to which the porous thin film is attached, is attached to the lower panel in a vacuum state.

Abstract: Provided is an apparatus for measuring a droplet length using a capacitive electrode including: a disposable panel; a board separated from the disposable panel and configured to be reused separately from the disposable panel; a sensing electrode unit patterned on an upper surface of the board and configured to measure a length of a droplet depending on a voltage value measured depending on a capacitance value of the fluid passing through the microfluid channel; a thin film provided on a lower surface of the disposable panel; and a negative pressure forming means configured to apply a negative pressure between the disposable panel and the board so that the disposable panel and the board are attached to or detached from each other.

Abstract: The present invention relates to a biomarker composition for diagnosing and predicting prognosis of prostate cancer, and that the detection rate and expression level of gene combination composed with AR (Androgen receptor), AR-V7 (Androgen receptor variant 7), EpCAM (Epithelial cell adhesion molecule) in blood tumor cells (CTC) isolated from patients, Epithelial cell adhesion molecule), KRT-19 (Cytokeratin 19), PSA (Prostate specific antigen), and PSMA (Prostate specific membrane antigen) in circulating tumor cells (CTCs) isolated from patients is related to the level of malignancy in prostate cancer is confirmed and thus the gene combination provides as a biomarker for prostate cancer diagnosis and a biomarker for prognosis prediction of prostate cancer.

Abstract: Provided is a microfluidic device including a lower panel including flow velocity measuring structures for measuring a flow velocity of a fluid; an upper panel separated from the lower panel and including a microfluidic channel through which a sample passes; a thin film provided at a portion where the lower panel and the upper panel adjoin each other in order to prevent the sample passing through the microfluidic channel from coming into direct contact with the flow velocity measuring structures, the thin film being configured to separate the lower panel and the upper panel to enable the lower panel to be repeatedly used multiple times; a specific functional unit configured to perform a specific operation on the sample passing through the microfluidic channel; and a negative pressure forming means configured to suck the lower panel and the upper panel with a negative pressure.

Abstract: Provided is a disposable flow velocity measuring device comprising: a first panel having a flow velocity measuring structure, and having additional micro protrusion patterns formed around the flow velocity measuring structure; a second panel separated from the first panel, and including a fluid channel through which a sample passes; a porous ultra-thin film formed on a portion, at which the first panel and the second panel come in contact with each other, so that the sample passing through the fluid channel does not directly come in contact with the flow velocity measuring structure, thereby separating the first panel and the second panel and removing micro-air bubbles included in the fluid passing through the fluid channel; a non-porous ultra-thin film formed in a partial region of the porous ultra-thin film; and a negative pressure forming means for applying negative pressure in order to adsorb the first panel and the second panel.

Abstract: Provided is a microfluidic device capable of removing microbubbles in a channel by using a porous thin film, the microfluidic device comprising: an upper panel comprising a microfluidic channel through which a fluid passes; a porous thin film attached to the bottom surface of the microfluidic channel so as to remove microbubbles included in the fluid that passes through the microfluidic channel; a lower panel contacting the bottom surface of the porous thin film and the upper panel, a path being provided in the lower panel so as to discharge microbubbles, which pass through the porous thin film, to the outside; and a vacuum-suctioning means for vacuum-suctioning the upper panel and the lower panel such that the microfluidic channel, to which the porous thin film is attached, is attached to the lower panel in a vacuum state.

Abstract: Provided is a device for measuring a microfluid flow velocity, having a structure separable by an ultra-thin film, the device including a first panel including a flow velocity measurement structure configured to measure a flow velocity of a fluid, a second panel configured to be separated from the first panel and including a microfluid channel through which a sample passes, and the ultra-thin film formed in a portion where the first panel and the second panel adjoin each other, the ultra-thin film being configured to separate the first panel and the second panel so that the sample passing through the microfluid channel does not come into direct contact with the flow velocity measurement structure, in which the first panel including the flow velocity measurement structure is usable multiple times repeatedly.

Abstract: The present invention relates to an apparatus and a method for separating single cells, and the apparatus includes: a fluid channel which has an upper panel and a lower panel and has a flow path which is formed between the upper panel and the lower panel and configured to convey a sample including a single cell; a single cell measuring unit which includes first and second electrodes which are provided on the fluid channel so as to be spaced apart from each other at a predetermined interval and apply electrical signals to the sample being conveyed through the flow path of the fluid channel, and a detection electrode which is provided between the first electrode and the second electrode and detects the single cell in the sample being conveyed through the flow path, such that the single cell measuring unit applies the electrical signals to the sample being conveyed through the flow path, detects the electrical signals of the sample to which the electrical signals are applied, and detects whether there is the sin

Abstract: The present invention relates to an apparatus for separating fine particles using magnetophoresis, and to a method for separating fine particles using same, and particularly, to an apparatus for separating fine particles using magnetophoresis, which includes a fine, patterned magnetic structure capable of quickly and efficiently separating even particles that are weakly magnetized and coupled to fine particles, and to a method for separating fine particles using same.

Abstract: The present invention relates to a microparticle separation apparatus assembly comprising multiple separable panels, more specifically, to a microparticle separation apparatus assembly having a novel structure, comprising: a first panel comprising a magnetic microstructure for applying magnetophoretic force to microparticles; and a second panel, which can be separated from the first panel and through which a sample comprising microparticles passes, wherein the first panel comprising the magnetic microstructure can be recycled.

Abstract: The present invention relates to a microparticle separation apparatus assembly comprising multiple separable panels, more specifically, to a microparticle separation apparatus assembly having a novel structure, comprising: a first panel comprising a magnetic microstructure for applying magnetophoretic force to microparticles; and a second panel, which can be separated from the first panel and through which a sample comprising microparticles passes, wherein the first panel comprising the magnetic microstructure can be recycled.

Abstract: The present invention relates to an apparatus for separating fine particles using magnetophoresis, and to a method for separating fine particles using same, and particularly, to an apparatus for separating fine particles using magnetophoresis, which includes a fine, patterned magnetic structure capable of quickly and efficiently separating even particles that are weakly magnetized and coupled to fine particles, and to a method for separating fine particles using same.

Abstract: A wheel end assembly includes a carrier and a wheel bearing assembly, and an outside inner race is integrally formed with a spindle of the wheel bearing assembly. The wheel end assembly includes: a carrier having a cylindrical member on its one side and a second through pipe on its other side; and a wheel bearing assembly comprising a spindle integrally formed with an outside inner race on its one side and having an insert groove on its other side, a hub having an outer race having ball receiving members receiving balls, an inside inner race provided on the inner side of the outer race by pressurization, and a seal member sealing a gap between the inside inner race and the outer race.

Abstract: The present invention relates to none return to zero (NRZ) modulation method. The NRZ optical modulation is performed by combining a clock signal and NRZ data at a sending end and signal distortion capable of being generated when the clock signal and the NRZ data are combined is optimized by controlling the magnitude and phase of the clock signal. At the receiving end, the clock signal is extracted by performing narrow band band-pass filtering of the detected optical signal transmitted from a transmitter and data is recovered using the clock signal. Therefore, a receiver structure for clock extraction is simpler, an error rate of data recovery is lower by clearly extracting the clock signal, and transmission distance of the optical signal is longer.

Abstract: An apparatus and method for monitoring an optical signal are provided. In the apparatus, a polarization adjusting unit converts the state of polarization of an optical signal. A polarization beam splitter splits the optical signal into a first polarization component and a second polarization component perpendicular to each other. An optical intensity measuring unit measures the optical intensity of the first polarization component. A feedback control unit controls the polarization adjusting unit so that the first and second polarization components are aligned to the two axes of the polarization beam splitter. A scrambler scrambles the optical signal input to the transmission optical fiber. According to the apparatus and method, optical signal-to-noise ratio (OSNR) can be measured accurately.

Abstract: Provided are a clock component generating apparatus using an asymmetrical distortion of NRZ (non-return to zero) signal and an optical transmission and reception system employing it. The clock component generation apparatus can make an NRZ optical signal have large clock component by asymmetrically distorting the rising and the falling waveform of the NRZ signal utilized in an optical communication system. This apparatus includes asymmetrical pull-up circuit for producing a pull-up function and pull-down circuit for pull-down function to thereby generate a clock component in the distorted NRZ data signal. The invention may advantageously be applied to an optical transmission and reception system.

Abstract: Provided are a polarization mode dispersion (PMD) compensator and method for automatically and rapidly compensating PMD occurring in an optical transmission fiber in a high-speed optical transmission system. The polarization mode dispersion compensator includes a separator and a differential time delay remover. The separator aligns orthogonal first and second polarization components of a received optical signal with respect to two orthogonal axes of a polarization beam splitter using optical signal information output via a second path of a first path and the second path of the two outputs of the polarization beam splitter, splits the first and second polarization components, and transmits the first polarization component via the first path and the second polarization component via the second path. The differential time delay remover receives the first and second polarization components that have been split to remove a differential time delay between the first and second polarization components.

Abstract: An apparatus for compensating a polarization mode dispersion including a polarization adjusting means for adjusting polarization states of an optical beam having a differential group delay based on a polarization adjusting feedback control signal; a polarization beam splitting means for splitting principal states of polarization of the adjusted optical beam into a first polarization and a second polarization; a time delaying means for the first polarization based on a time delay feedback control signal; a polarization adjustment controlling means for controlling the polarization adjusting means based on a polarization adjusting feedback control signal; a time delay controlling means for controlling the time delaying means based on a time delay controlling feedback signal; and an electric combining means for combining a time-compensated first polarization and the second polarization transmitted through the optical tap.