Abstract: The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.

Abstract: The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.

Abstract: The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.

Abstract: The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.

Abstract: The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.

Abstract: Provided are a method for producing a sulfonyl amidine compound, which has an excellent gonadotropin releasing hormone receptor antagonism and is useful as a therapeutic agent for gonadotropin-dependent diseases (for example, prostate cancer, breast cancer, endometriosis, uterine fibroid, prostatic hyperplasia, or the like) or a salt thereof, and a synthesis intermediate useful in the production method. The production method of the present invention controls formation of a by-product which is hardly removed unless column purification is conducted and racemization of a target compound, thereby obtaining the target compound with a high purity, and therefore, the production method is suitable for industrial production.

Abstract: Provided are a method for producing a sulfonyl amidine compound, which has an excellent gonadotropin releasing hormone receptor antagonism and is useful as a therapeutic agent for gonadotropin-dependent diseases (for example, prostate cancer, breast cancer, endometriosis, uterine fibroid, prostatic hyperplasia, or the like) or a salt thereof, and a synthesis intermediate useful in the production method. The production method of the present invention controls formation of a by-product which is hardly removed unless column purification is conducted and racemization of a target compound, thereby obtaining the target compound with a high purity, and therefore, the production method is suitable for industrial production.

Abstract: The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.

Abstract: An enzyme immunoassay chip having, as micro channels, a reaction liquid leading-in flow passage part, a reaction flow passage part, and detection flow passage part sequentially disposed on a substrate continuously to each other, comprising an installed part for bead-bodies supporting antibodies and the bead-body flow stopping part formed in the micro channel of the reaction flow passage part, wherein enzyme reactive product flowing beyond the flow stopping part can be analyzed by using the chip.

Abstract: In a microfluid system it is intended to expand the application range of samples capable of being treated, decrease the amount of samples used, and prevent deterioration of samples with the lapse of time. In a microfluid system having a microchip for feeding plural samples to a treating portion and performing predetermined treatments, plural sample servers for storage of the samples therein are provided in the microchip, the sample servers and the treating portion are connected with each other through capillary channels provided respectively on outlet sides of the sample servers, and a pressurizing device for pressurizing the samples stored in the sample servers and feeding them to the treating portion is provided.

Abstract: An enzyme immunoassay chip having, as micro channels, a reaction liquid leading-in flow passage part, a reaction flow passage part, and detection flow passage part sequentially disposed on a substrate continuously to each other, comprising an installed part for bead-bodies supporting antibodies and the bead-body flow stopping part formed in the micro channel of the reaction flow passage part, wherein enzyme reactive product flowing beyond the flow stopping part can be analyzed by using the chip.

Abstract: In an electronic computer system in which a plurality of OSs are operated, a plurality of input-output arrangement information defined in response to each of a plurality of OSs and a correspondence table indicative of a correspondence relationship between each OS and each input-output arrangement information are created previously and stored in a control information storage means. When an input-output request is issued from an arbitrary OS, the central processing unit identifies the corresponding OS, and recognizes input-output arrangement information corresponding to the identified OS based on the correspondence table. Then, the central processing unit executes an input-output processing based on the recognized input-output arrangement information.

Abstract: A connection method of a plurality of input/output channels between a plurality of sub-channels of an information processing system having a virtual machine running on a physical machine under control of a hypervisor and a plurality of devices. The method includes issuing from the hypervisor a command for setting configuration information defining a plurality of configuration structures between the sub-channels set for the respective virtual machines and the devices in a storage device and acquiring configuration information containing the sub-channel corresponding to a designated device from the configuration information corresponding to one of the virtual machines based on the device designation contained in the input/output command from the one virtual machine. The virtual machines are enabled after the issuance of the set command and before the issuance of the input/output command.

Abstract: A topical preparation for treating otophathy which contains ofloxacin or a salt thereof as an active ingredient is disclosed.

Abstract: In an input/output process device for controlling data transfer between a central processing unit and an input/output device through a channel by use of any of a plurality of input/output control devices connected to the input/output device, a memory unit is disposed so as to store information representing the address of the input/output control device in association with an identification number of the channels connected to the input/output control device. When selecting the channel for data transfer, the input/output process device reads out the information representing the address of the input/output control device from the memory unit and generates the address for the input/output control device on the basis of the information read out.

Abstract: A process for manufacturing a silver halide color photographic material is disclosed. The photographic material comprises a blue light-sensitive layer-unit, a green light-sensitive layer-unit and a red light-sensitive layer-unit in which at least one of the light-sensitive layer-units comprises two or three silver halide emulsion layers being substantially the same in spectral sensitivity and different in speed from each other.