Patents by Inventor Kim Langone

Kim Langone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene expression markers for prediction of patient response to chemotherapy
    Patent number: 8632980
    Abstract: The present invention relates to gene sets useful in assessing prognosis and/or predicting the response of cancer, e.g. colorectal cancer to chemotherapy. In addition, the invention relates to a clinically validated cancer test, e.g. colorectal test, for assessment of prognosis and/or prediction of patient response to chemotherapy, using expression analysis. The present invention accommodates the use of archived paraffin embedded biopsy material for assay of all markers in the relevant gene sets and therefore is compatible with the most widely available type of biopsy material.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: January 21, 2014
    Assignees: Genomic Health, Inc., NSABP Foundation, Inc
    Inventors: Joffre B. Baker, Wayne Cowens, Kim Langone, James Hackett, Drew Watson, Soonmyung Paik
  • Gene Expression Markers for Prediction of Patient Response to Chemotherapy
    Publication number: 20120040842
    Abstract: The present invention relates to gene sets useful in assessing prognosis and/or predicting the response of cancer, e.g. colorectal cancer to chemotherapy. In addition, the invention relates to a clinically validated cancer test, e.g. colorectal test, for assessment of prognosis and/or prediction of patient response to chemotherapy, using expression analysis. The present invention accommodates the use of archived paraffin embedded biopsy material for assay of all markers in the relevant gene sets and therefore is compatible with the most widely available type of biopsy material.
    Type: Application
    Filed: October 21, 2011
    Publication date: February 16, 2012
    Inventors: Joffre B. Baker, Wayne Cowens, Kim Langone, James Hackett, Drew Watson, Soonmyung Paik
  • Gene expression markers for prediction of patient response to chemotherapy
    Patent number: 8067178
    Abstract: The present invention relates to gene sets useful in assessing prognosis and/or predicting the response of cancer, e.g. colorectal cancer to chemotherapy. In addition, the invention relates to a clinically validated cancer test, e.g. colorectal test, for assessment of prognosis and/or prediction of patient response to chemotherapy, using expression analysis. The present invention accommodates the use of archived paraffin embedded biopsy material for assay of all markers in the relevant gene sets and therefore is compatible with the most widely available type of biopsy material.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: November 29, 2011
    Assignees: Genomic Health, Inc., NSABP Foundation, Inc.
    Inventors: Joffre B. Baker, Wayne Cowens, Kim Langone, James Hackett, Drew Watson, Soonmyung Paik
  • GENE EXPRESSION PROFILE ALGORITHM AND TEST FOR LIKELIHOOD OF RECURRENCE OF COLORECTAL CANCER AND RESPONSE TO CHEMOTHERAPY
    Publication number: 20100285980
    Abstract: Algorithm-based molecular assays that involve measurement of expression levels of prognostic and/or predictive genes, or co-expressed genes thereof, from a biological sample obtained from a cancer patient, and analysis of the measured expression levels to provide information concerning the likelihood of recurrence of colorectal cancer and/or the likelihood of a beneficial response to chemotherapy for the patient are provided herein. Methods of analysis of gene expression values of prognostic and/or predictive genes, as well as methods of identifying gene expression-tumor region ratios, tumor-associated stromal surface area, and gene cliques, i.e. genes that co-express with a validated biomarker and thus may be substituted for that biomarker in an assay, are also provided.
    Type: Application
    Filed: April 30, 2010
    Publication date: November 11, 2010
    Inventors: Steven Shak, Drew Watson, Xitong Li, Lawrence Lee, Kim Langone
  • GENE EXPRESSION MARKERS FOR PREDICTION OF PATIENT RESPONSE TO CHEMOTHERAPY
    Publication number: 20090305277
    Abstract: The present invention relates to gene sets useful in assessing prognosis and/or predicting the response of cancer, e.g. colorectal cancer to chemotherapy. In addition, the invention relates to a clinically validated cancer test, e.g. colorectal test, for assessment of prognosis and/or prediction of patient response to chemotherapy, using expression analysis. The present invention accommodates the use of archived paraffin embedded biopsy material for assay of all markers in the relevant gene sets and therefore is compatible with the most widely available type of biopsy material.
    Type: Application
    Filed: March 13, 2009
    Publication date: December 10, 2009
    Inventors: Joffre B. Baker, Wayne Cowens, Kim Langone, James Hackett, Drew Watson, Soonmyung Paik
  • Gene expression markers for prediction of patient response to chemotherapy
    Publication number: 20090258795
    Abstract: A method of predicting clinical outcome in a subject diagnosed with cancer and treated with chemotherapy comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample comprising cancer cells obtained from the subject.
    Type: Application
    Filed: March 14, 2008
    Publication date: October 15, 2009
    Applicants: GENOMIC HEALTH, INC., NSABP FOUNDATION, INC.
    Inventors: Wayne Cowens, Joffre Baker, Kim Langone, Drew Watson, James Hackett, Soonmyung Paik