Patents by Inventor Kimberly A. Noonan

Kimberly A. Noonan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MARROW INFILTRATING LYMPHOCYTES (MILS) AS A SOURCE OF T-CELLS FOR CHIMERIC ANTIGEN RECEPTOR (CAR) THEREAPY
    Publication number: 20230210990
    Abstract: In some embodiments, marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a MIL obtained from bone marrow comprising a chimeric antigen receptor. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR.
    Type: Application
    Filed: November 30, 2022
    Publication date: July 6, 2023
    Inventors: Ivan M. Borrello, Kimberly A. Noonan, Drew M. Pardoll, Valentina Hoyos Velez
  • METHODS FOR ENRICHING MARROW INFILTRATING LYMPHOCYTES ("MILS"), COMPOSITIONS CONTAINING ENRICHED MILS, AND METHODS OF USING ENRICHED MILS
    Publication number: 20230100744
    Abstract: A method for enriching or isolating tumor specific MILs is described. This method includes the steps of preparing MILs from the bone marrow of a cancer patient; evaluating the MILs for gene expression, metabolic profile, or phenotype; and selecting and isolating the MILs that exhibit the gene expression, metabolic profile, or phenotype. Compositions containing the MILs and methods of treating cancer with the enriched MILs are also described.
    Type: Application
    Filed: February 26, 2021
    Publication date: March 30, 2023
    Applicants: WINDMIL THERAPEUTICS, INC., THE JOHNS HOPKINS UNIVERSITY
    Inventors: Ivan R. Borrello, Kimberly A. Noonan
  • MARROW INFILTRATING LYMPHOCYTES (MILS) AS A SOURCE OF T-CELLS FOR CHIMERIC ANTIGEN RECEPTOR (CAR) THEREAPY
    Publication number: 20230016031
    Abstract: In some embodiments, marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs; and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR.
    Type: Application
    Filed: September 15, 2022
    Publication date: January 19, 2023
    Inventors: Ivan M. Borrello, Kimberly A. Noonan, Drew M. Pardoll, Valentina Hoyos Velez
  • ACTIVATION OF MARROW INFILTRATING LYMPHOCYTES IN HYPOXIC ALTERNATING WITH NORMOXIC CONDITIONS
    Publication number: 20230000919
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Application
    Filed: July 14, 2022
    Publication date: January 5, 2023
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Marrow infiltrating lymphocytes (MILs) as a source of T-cells for chimeric antigen receptor (CAR) therapy
    Patent number: 11478548
    Abstract: In some embodiments, marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs; and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: October 25, 2022
    Assignee: The Johns Hopkins University
    Inventors: Ivan M. Borrello, Kimberly A. Noonan, Drew M. Pardoll, Valentina Hoyos Velez
  • MARROW INFILTRATING LYMPHOCYTES (MILs) EXPRESSING CHIMERIC ANTIGEN RECEPTORS (CAR), METHOD OF MANUFACTURING SAME, AND METHOD OF USING IN THERAPY
    Publication number: 20220257650
    Abstract: Marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs; and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor, resulting in a CAR-MIL.
    Type: Application
    Filed: November 27, 2019
    Publication date: August 18, 2022
    Applicant: WINDMIL THERAPEUTICS, INC.
    Inventors: Kimberly A. Noonan, Ivan Borrello, Eric R. Lutz, Lakshmi Rudraraju, Srikanta Jana, Ido Weiss, Valentina Hoyos
  • Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions
    Patent number: 11406666
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: August 9, 2022
    Assignee: The Johns Hopkins University
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Lung Cancer Specific Marrow Infiltrating Lymphocytes and Uses Thereof
    Publication number: 20220168350
    Abstract: Lung cancer specific marrow infiltrating lymphocytes (“MILs”) and methods for making and using the same are described. Disclosed herein is a method for treating a subject having lung cancer with marrow infiltrating lymphocytes, the method comprising the steps of: (a) culturing a bone marrow sample obtained from the subject having lung cancer with an anti-CD3 antibody and an anti-CD28 antibody in a hypoxic environment to produce hypoxic-activated marrow infiltrating lymphocytes; (b) culturing the hypoxic-activated marrow infiltrating lymphocytes in a normoxic environment to produce the therapeutic activated marrow infiltrating lymphocytes; and (c) administering the therapeutic activated marrow infiltrating lymphocytes to the subject having lung cancer.
    Type: Application
    Filed: March 20, 2020
    Publication date: June 2, 2022
    Applicants: WINDMIL THERAPEUTICS, INC., THE JOHNS HOPKINS UNIVERSITY
    Inventors: Kimberly A. Noonan, Ivan Borrello
  • ACTIVATION OF MARROW INFILTRATING LYMPHOCYTES IN HYPOXIC ALTERNATING WITH NORMOXIC CONDITIONS
    Publication number: 20220016172
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Application
    Filed: September 30, 2021
    Publication date: January 20, 2022
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Marrow Infiltrating Lymphocytes With Increased Clonality and Uses Thereof
    Publication number: 20210338730
    Abstract: The disclosure provides for compounds comprising cancer specific marrow infiltrating lymphocytes and methods for making and using the same.
    Type: Application
    Filed: November 1, 2019
    Publication date: November 4, 2021
    Applicant: WINDMIL THERAPEUTICS, INC.
    Inventors: Kimberly A. Noonan, Eric R. Lutz
  • Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions
    Patent number: 11160830
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: November 2, 2021
    Assignee: The Johns Hopkins University
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • MARROW INFILTRATING LYMPHOCYTES (MILs) EXPRESSING CHIMERIC ANTIGEN RECEPTORS (CAR), METHOD OF MANUFACTURING SAME, AND METHOD OF USING IN THERAPY
    Publication number: 20210154233
    Abstract: Marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs; and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor, resulting in a CAR-MIL. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR. In some aspects, the condition is cancer, such as prostate cancer.
    Type: Application
    Filed: February 1, 2021
    Publication date: May 27, 2021
    Applicant: WINDMIL THERAPEUTICS, INC.
    Inventors: Kimberly A. Noonan, Ivan Borrello, Eric R. Lutz, Lakshmi Rudraraju, Srikanta Jana, Ido Weiss, Valentina Hoyos
  • Prostate Cancer Specific Marrow Infiltrating Lymphocytes and Uses Thereof
    Publication number: 20210000876
    Abstract: The disclosure provides for compounds comprising prostate cancer specific marrow infiltrating lymphocytes and methods for making and using the same.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 7, 2021
    Applicant: WINDMIL THERAPEUTICS, INC.
    Inventors: Kimberly A. Noonan, Ivan Borrello
  • Use of Post-Transplant Cyclophosphamide Treated Allogenic Marrow Infiltrating Lymphocytes to Augment Anti-Tumor Immunity
    Publication number: 20200171089
    Abstract: The present invention relates to the field of cancer therapy. More specifically, the present invention provides methods and compositions useful for augmenting anti-tumor immunity. In one embodiment, a method for treating or preventing post-allogeneic transplant relapse in a subject who has received post-transplant cyclophosphamide treatment comprises the steps of (a) obtaining a bone marrow sample from the subject; (b) expanding the marrow infiltrating lymphocytes (MILs) present in the sample; and (c) administering the MILs to the subject. In a specific embodiment, the method significantly reduces the likelihood of developing GVHD.
    Type: Application
    Filed: December 30, 2019
    Publication date: June 4, 2020
    Applicant: WINDMIL THERAPEUTICS, INC.
    Inventors: Ivan M. Borrello, Kimberly A. Noonan, Leonido Luznik
  • Activation of Marrow Infiltrating Lymphocytes in Hypoxic Alternating with Normoxic Conditions
    Publication number: 20190350982
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Application
    Filed: July 30, 2019
    Publication date: November 21, 2019
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Compositions and Methods for Modulating the Immune System
    Publication number: 20190330306
    Abstract: Embodiments provided for herein relate to compositions and methods related to chimeric proteins that can be used to modulate a subject's immune system and, for example, treat cancer.
    Type: Application
    Filed: December 21, 2017
    Publication date: October 31, 2019
    Applicant: WINDMIL THERAPEUTICS, INC.
    Inventors: Kimberly A. Noonan, Eric R. Lutz, Ivan Borrello
  • Activation of Marrow Infiltrating Lymphocytes in Hypoxic Alternating with Normoxic Conditions
    Publication number: 20190298768
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Application
    Filed: December 3, 2018
    Publication date: October 3, 2019
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions
    Patent number: 10406178
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: September 10, 2019
    Assignee: The Johns Hopkins University
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions
    Patent number: 10172887
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: January 8, 2019
    Assignee: The Johns Hopkins University
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Marrow Infiltrating Lymphocytes (MILS) as a Source of T-Cells for Chimeric Antigen Receptor (CAR) Thereapy
    Publication number: 20180200367
    Abstract: In some embodiments, marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs; and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR.
    Type: Application
    Filed: July 8, 2016
    Publication date: July 19, 2018
    Inventors: Ivan M. Borrello, Susan Lee, Kimberly A. Noonan, Drew M. Pardoll