Abstract: An improved ligating system with a ligating barrel having an adjustable diameter for use with endoscopes of varying sizes is disclosed. The adjustable diameter may be provided by a collet, a flexible helical band, a plurality of screws, or a tapered elastomeric section.

Abstract: An intragastric device generally comprises a strip digestive-resistant mesh material that is operable between a first configuration and a second configuration. The first configuration is sufficiently small to permit introduction of the digestive-resistant mesh material into a gastric lumen of the mammal. The second configuration is sufficiently large to prevent the digestive-resistant mesh material from passing through the mammals pylorus, thereby permitting the mesh member to act as an artificial bezoar. Methods and devices for delivering the mesh member are also provided, including a pusher that is operable to engage and disengage the mesh member for delivery through the gastric lumen via a delivery sheath.