Patents by Inventor Kimberly White

Kimberly White has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Patent number: 7329657
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: February 12, 2008
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Robert Hecker, David F. McComsey
  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Patent number: 7304060
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: December 4, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Robert Hecker, David F. McComsey
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20070213386
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: May 8, 2007
    Publication date: September 13, 2007
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, David McComsey, Kimberly White, Hong Ye, Leonard Hecker, Bruce Conway, Keith Demarest
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20070213387
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: May 8, 2007
    Publication date: September 13, 2007
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, David McComsey, Kimberly White, Hong Ye, Leonard Hecker, Bruce Conway, Keith Demarest
  • Substituted pyrrolines as kinase inhibitors
    Patent number: 7232906
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: June 19, 2007
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Han Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker, Bruce Conway, Keith Demarest
  • Novel heteroaryl peptidomimetics as thrombin receptor antagonists
    Publication number: 20060009396
    Abstract: The invention is directed to novel heteroaryl peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, angiogenesis and related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted heteroaryl peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Application
    Filed: September 15, 2005
    Publication date: January 12, 2006
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, William Hoekstra, Kimberly White
  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Patent number: 6849643
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: February 1, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Robert Hecker, David F. McComsey
  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Publication number: 20050004202
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: August 2, 2004
    Publication date: January 6, 2005
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Hecker, David McComsey
  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Publication number: 20040259928
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): 1
    Type: Application
    Filed: July 6, 2004
    Publication date: December 23, 2004
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Robert Hecker, David F. McComsey
  • Novel heteroaryl peptidomimetics as thrombin receptor antagonists
    Publication number: 20040138141
    Abstract: The invention is directed to novel heteroaryl peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, angiogenesis and related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted heteroaryl peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Application
    Filed: December 10, 2003
    Publication date: July 15, 2004
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, William J. Hoekstra, Kimberly White
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20040054180
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: June 4, 2003
    Publication date: March 18, 2004
    Inventors: Han Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker, Bruce Conway, Keith Demarest
  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Publication number: 20030055097
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): 1
    Type: Application
    Filed: December 6, 2001
    Publication date: March 20, 2003
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Robert Hecker, David F. McComsey
  • Parallel high throughput method and kit
    Publication number: 20020137888
    Abstract: A parallel high throughput method and kit for the discovery of small molecule interactors of target proteins, in particular, target proteins expressed from entire genomes or subsets thereof. The target module is prepared by binding selectively a target protein, modified to allow its detection, to a surrogate ligand that is linked to an individually detectable bead. Sets of target modules are mixed together in each chamber of a multi-chamber container. A test compound or collection of test compounds is added to each chamber, and the interaction of a compound with each target module is observed. A compound that is specific for a particular target protein will displace that protein from its target module. The identity of the target module so disrupted is determined by identifying the particular bead to which the displaced target protein was attached.
    Type: Application
    Filed: July 30, 2001
    Publication date: September 26, 2002
    Inventors: Paul Bernasconi, Ray D. Carpenter, Gary K. Powell, Robert M. Petrovich, Kimberly A. White, Jennifer A. Hunt
  • Fungal target genes and methods
    Patent number: 6307037
    Abstract: The invention relates to genes isolated from Ashbya gossypii that code for proteins essential for normal fungal growth and development. The invention also includes the methods of using these proteins to discover new fungicides, based on the essentiality of the gene for normal growth and development. The invention can also be used in a screening assay to identify inhibitors that are potential fungicides.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: October 23, 2001
    Assignee: Syngenta Participations AG
    Inventors: Thomas Deane Gaffney, Albert Flavier, Michelle M. Cloyd Kirksey, Peter Phillippsen, Frederick Dietrich, Jurgen Wendland, Paul Bernasconi, Kimberly White, Witold Filipowicz