Patents by Inventor Kin S. Lam

Kin S. Lam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bis-indole pyrroles useful as antimicrobials agents
    Patent number: 7375129
    Abstract: Compounds of Formula I, commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-indole pyrroles and their derivatives or analogs having antimicrobial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating bacterial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: May 20, 2008
    Assignee: Nereus Pharmaceuticals, Inc.
    Inventors: Scott S. Mitchell, Kin S. Lam, Jennifer Grodberg, Barbara C. Potts, Ginger Tsueng, Donald J. White, Katherine Anne Reed
  • Compositions and methods for altering biosynthesis of taxanes and taxane-related compounds
    Patent number: 7273755
    Abstract: Isolated nucleic acid and amino acid sequences for phenylalanine aminomutase enzyme and methods for purifying this enzyme are provided. Methods for altering biosynthesis of compounds in plant cell cultures are also provided. In particular, methods for altering production of taxanes and taxane-related compounds are provided.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: September 25, 2007
    Assignee: Bristol Myers Squibb Co.
    Inventors: Christopher L. Steele, Yijun Chen, Brian A. Dougherty, Sandra Hofstead, Kin S. Lam, Wenying Li, Zizhuo Xing
  • Bis-indole pyrroles useful as antimicrobials agents
    Patent number: 7166634
    Abstract: Compounds of Formula I, commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-indole pyrroles and their derivatives or analogs having antimicrobial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating bacterial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.
    Type: Grant
    Filed: January 21, 2005
    Date of Patent: January 23, 2007
    Assignee: Nereus Pharmaceuticals, Inc.
    Inventors: Scott S. Mitchell, Kin S. Lam, Jennifer Grodberg, Barbara C. Potts, Ginger Tsueng, Donald J. White, Katherine Anne Reed
  • Compositions and methods for altering biosynthesis of taxanes and taxane-related compounds
    Publication number: 20030175913
    Abstract: Isolated nucleic acid and amino acid sequences for phenylalanine aminomutase enzyme and methods for purifying this enzyme are provided. Methods for altering biosynthesis of compounds in plant cell cultures are also provided. In particular, methods for altering production of taxanes and taxane-related compounds are provided.
    Type: Application
    Filed: February 10, 2003
    Publication date: September 18, 2003
    Inventors: Christopher L. Steele, Yijun Chen, Brian A. Dougherty, Sandra Hofstead, Kin S. Lam, Wenying Li, Zizhuo Xing
  • Water soluble thiazolyl peptide derivatives
    Publication number: 20020065219
    Abstract: Novel thiazolyl peptide compounds useful for the treatment of serious bacterial infections, and pharmaceutical compositions thereof are provided.
    Type: Application
    Filed: August 13, 2001
    Publication date: May 30, 2002
    Inventors: B. Narasimhulu Naidu, Wenying Li, Kin S. Lam, Margaret E. Sorenson, John A. Wichtowski, Timothy P. Connolly, Yasutsugu Ueda, Joanne J. Bronson, Yunhui Zhang, Oak K. Kim
  • Halo- or hydroxy-substituted nocathiacin antibiotics
    Patent number: 6287827
    Abstract: Fermentation of Nocardia sp. ATCC-202099 in the presence of a halogen- or hydroxy-substituted tryptophan precursor yields a novel corresponding halogen- or hydroxy-substituted nocathiacin compound which has broad spectrum antibiotic activity against Gram-positive bacteria and has in vivo efficacy in animals.
    Type: Grant
    Filed: May 1, 2000
    Date of Patent: September 11, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Wenying Li, John E. Leet, Kin S. Lam
  • Nocathiacin antibiotics
    Patent number: 6218398
    Abstract: Novel thiazolyl peptide antibiotic compounds, including nocathiacin I, II and III, are disclosed. Also, novel microorganism ATCC-202099 is disclosed.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: April 17, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: John E. Leet, Helen A. Ax, Donald R. Gustavson, Daniel M. Brown, Laura Turner, Kimberly Brown, Wenying Li, Kin S. Lam
  • Rebeccamycin analogs by tryptophan analogs feeding
    Patent number: 5468849
    Abstract: Addition of certain tryptophan analogs to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of new rebeccamycin analogs having advantageous antitumor properties.
    Type: Grant
    Filed: March 21, 1994
    Date of Patent: November 21, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kin S. Lam, Daniel R. Schroeder, Jacqueline Mattei, Salvatore Forenza, James A. Matson
  • Antitumor antibiotic
    Patent number: 5378463
    Abstract: A certain fermentation product of Actinomadura strain Q473-8 yield, when suitably treated, a novel compound having both antibiotic and antitumor activities.
    Type: Grant
    Filed: October 25, 1993
    Date of Patent: January 3, 1995
    Assignee: Bristol Myers Squibb Co.
    Inventors: Daniel R. Schroeder, Kin S. Lam, Jacqueline M. Veitch
  • Antitumor antibiotic BMY-41219
    Patent number: 5344823
    Abstract: A new antitumor antibiotic designated BMY-41219 is produced by fermentation of Saccharothrix aerocolonigenes ATCC 39243. The BMY-41219 antibiotic exhibits antitumor activity.
    Type: Grant
    Filed: February 6, 1992
    Date of Patent: September 6, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kin S. Lam, Leonard A. McDonald, Jacqueline Mattei, Salvatore Forenza, James A. Matson
  • Antitumor antibiotic BMY-41219
    Patent number: 5326754
    Abstract: An antitumor antibiotic designated BMY-41219 is produced by fermentation of Saccharothrix aerocolonigenes ATCC 39243. The BMY-41219 antibiotic exhibits antitumor activity.
    Type: Grant
    Filed: May 18, 1993
    Date of Patent: July 5, 1994
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Kin S. Lam, Leonard A. McDonald, Jacqueline Mattei, Salvatore Forenza, James A. Matson
  • Antitumor antibiotic
    Patent number: 5304373
    Abstract: A certain fermentation product of Actinomadura strain Q473-8 yields, when suitably treated, a novel compound having both antibiotic and antitumor activities.
    Type: Grant
    Filed: October 22, 1991
    Date of Patent: April 19, 1994
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Daniel R. Schroeder, Kin S. Lam, Jacqueline M. Veitch
  • Antitumor process employing novel fermentate of an Actinomadura strain
    Patent number: 5281417
    Abstract: A certain fermentation product of Actinomadura strain Q473-8 yields, when suitably treated, a novel compound having both antibiotic and antitumor activities.
    Type: Grant
    Filed: February 12, 1993
    Date of Patent: January 25, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel R. Schroeder, Kin S. Lam, Jacqueline M. Veitch
  • Antitumor antibiotic BMY-42448
    Patent number: 5270186
    Abstract: An antibiotic designated BMY-42448 is produced by fermentation of Micromonospora narashinoensis strain C39217-R109-7 (ATCC-53791). BMY-42448 exhibits both in vitro and in vivo antitumor activity.
    Type: Grant
    Filed: October 10, 1991
    Date of Patent: December 14, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel R. Schroeder, Kin S. Lam, Grace A. Hesler, Donald R. Gustavson, Koji Tomita, Ronald L. Berry
  • Rebeccamycin
    Patent number: 5158938
    Abstract: Addition of bromine to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of a new rebeccamycin derivative having advantageous antineoplastic properties.
    Type: Grant
    Filed: September 23, 1991
    Date of Patent: October 27, 1992
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kin S. Lam, Daniel R. Schroeder, Jacqueline Mattei, James A. Matson, Salvatore Forenza
  • Antitumor antibiotic BMY-42428
    Patent number: 5087567
    Abstract: An antitumor antibiotic designated BMY-42428 is produced by fermentation of Actinomadura madurae ATCC-53806. The BMY-42428 antibiotic exhibits both antimicrobial and antitumor activities.
    Type: Grant
    Filed: January 12, 1990
    Date of Patent: February 11, 1992
    Assignee: Bristol-Myers Squibb Company
    Inventors: Thomas T. Dabrah, Grace A. Hesler, Sandra J. Hofstead, Kin S. Lam, Jacqueline M. Mattei, Daniel R. Schroeder, Koji Tomita
  • Antitumor antibiotic BMY-42448
    Patent number: 5082933
    Abstract: A new antibiotic designated BMY-42448 is produced by fermentation of Micromonospora narashinoensis strain C39217-R109-7 (ATCC-53791). BMY-42448 exhibits both in vitro and in vivo antitumor activity.
    Type: Grant
    Filed: January 10, 1990
    Date of Patent: January 21, 1992
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Daniel R. Schroeder, Kin S. Lam, Grace A. Hesler, Donald R. Gustavson, Koji Tomita, Ronald L. Berry
  • BMY-41950 antitumor antibiotic
    Patent number: 5073633
    Abstract: An antitumor antibiotic designated BMY-41950 is produced by fermentation of Streptomyces staurosporeus ATCC 55006 or Streptomyces hygroscopicus ATCC 53730. The BMY-41950 antibiotic exhibits both antimicrobial and antitumor activities.
    Type: Grant
    Filed: November 5, 1990
    Date of Patent: December 17, 1991
    Assignee: Bristol-Myers Company
    Inventors: Daniel Schroeder, Kin S. Lam, Jacqueline Mattei, Grace A. Hesler
  • BMY-41950 antitumor antibiotic
    Patent number: 5015578
    Abstract: A new antitumor antibiotic designated BMY-41950 is produced by fermentation of Streptomyces staurosporeus ATCC 55006 or Streptomyces hygroscopicus ATCC 53730. The BMY-41950 antibiotic exhibits both antimicrobial and antitumor activities.
    Type: Grant
    Filed: February 20, 1990
    Date of Patent: May 14, 1991
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel Schroeder, Kin S. Lam, Jacqueline Mattei, Grace A. Hesler
  • Antitumor antibiotic kedarcidin
    Patent number: 5001112
    Abstract: Kedarcidin is a protein antitumor antibiotic produced by Streptoalloteichus sp. nov. strain L585-6, ATCC 53650. The antibiotic comprises a non-protein chromophore and a single chain polypeptide having 114 amino acid residues.
    Type: Grant
    Filed: March 17, 1989
    Date of Patent: March 19, 1991
    Assignee: Bristol-Myers Company
    Inventors: Sandra J. Hofstead, James A. Matson, Kin S. Lam, Salvatore Forenza, James A. Bush, Koji Tomita