Patents by Inventor Kirstie Swingle

Kirstie Swingle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRISPR-CAS /TRANSCRIPTION FACTOR-BASED COMPETITION ASSAY FOR DETECTION OF MOLECULAR ANALYTES
    Publication number: 20240094229
    Abstract: Provided herein are highly modular and sensitive biosensors for small molecule detection using CRISPR/C as enzymes having collateral single-stranded nucleic acid cleavage activity. Also provided herein are uses of the biosensors in detection platforms for convenient, low-cost assessment of safety and purity of consumable samples, environmental samples, and agricultural products.
    Type: Application
    Filed: September 8, 2023
    Publication date: March 21, 2024
    Inventors: Alexander Green, Soma Chaudhary, Kirstie Swingle
  • Integrated diagnostic devices having embedded biomolecular computing systems and uses thereof
    Patent number: 11547997
    Abstract: Integrated diagnostic devices comprising peptide-DNA conjugates for analyte detection, an embedded biomolecular computing system for sample analysis, and a layered device architecture are provided herein. In particular, provided herein are devices comprising a layered architecture that enables diagnostic reagents, sample components, and reaction products to flow through the system with minimal user intervention.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: January 10, 2023
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Alexander A. Green, Matthew Gilliam, Kirstie Swingle, Nicholas Stephanopoulos, Neal Woodbury
  • PROXIMITY-DRIVEN ACTIVATION OF CRISPR-CAS SYSTEMS FOR DETECTION OF DIVERSE MOLECULAR ANALYTES
    Publication number: 20220403444
    Abstract: Provided herein are methods and compositions for rapid, highly sensitive detection of molecular analytes such as antibodies, proteins, and small molecules using protein-driven nucleic acid assemblies to activate CRISPR-Cas nucleases. Also provided herein are uses of the sensitive analyte detection methods in an analyte detection platform and in convenient low-cost diagnostic assays such as lateral flow devices for point-of-care use.
    Type: Application
    Filed: April 27, 2020
    Publication date: December 22, 2022
    Inventors: Alexander Green, Kirstie Swingle
  • INTEGRATED DIAGNOSTIC DEVICES HAVING EMBEDDED BIOMOLECULAR COMPUTING SYSTEMS AND USES THEREOF
    Publication number: 20200386750
    Abstract: Integrated diagnostic devices comprising peptide-DNA conjugates for analyte detection, an embedded biomolecular computing system for sample analysis, and a layered device architecture are provided herein. In particular, provided herein are devices comprising a layered architecture that enables diagnostic reagents, sample components, and reaction products to flow through the system with minimal user intervention.
    Type: Application
    Filed: May 8, 2017
    Publication date: December 10, 2020
    Inventors: Alexander A. Green, Matthew Gilliam, Kirstie Swingle, Nicholas Stephanopoulos, Neal Woodbury