Patents by Inventor Kiyofumi Ishikawa
Kiyofumi Ishikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6991150Abstract: A recess formed in close contact with a thin-walled portion 3a of a workpiece to store molten metal at a surfaced portion, a jig 4 manufactured from a material with a higher heat-resisting temperature than that of the molten metal and a satisfactorily large heat capacity, a step (A) wherein the jig is installed on the workpiece, a preheating step (B) in which the workpiece and the jig are preheated to a predetermined temperature under the condition that jig 4 is installed, a build up welding step (C) for build up welding the thin-walled portion of the workpiece and forming weld beads at surfaced portion, and a jig-removing step (D) for removing the jig after weld beads solidify completely.Type: GrantFiled: August 29, 2003Date of Patent: January 31, 2006Assignees: Ishikawajima-Harima Heavy Industries Co., Ltd., Ishikawajima Inspection & Instrumentation Co., Ltd.Inventors: Akihiro Sato, Kiyofumi Ishikawa, Hiroyuki Miyazawa, Hiroto Yamaoka, Yasuhiro Aoki
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Publication number: 20050173496Abstract: A recess formed in close contact with a thin-walled portion 3a of a workpiece to store molten metal at a surfaced portion, a jig 4 manufactured from a material with a higher heat-resisting temperature than that of the molten metal and a satisfactorily large heat capacity, a step (A) wherein the jig is installed on the workpiece, a preheating step (B) in which the workpiece and the jig are preheated to a predetermined temperature under the condition that jig 4 is installed, a build up welding step (C) for build up welding the thin-walled portion of the workpiece and forming weld beads at surfaced portion, and a jig-removing step (D) for removing the jig after weld beads solidify completely.Type: ApplicationFiled: August 29, 2003Publication date: August 11, 2005Applicants: Ishikawajima-Harima Heavy Industries Co., Ltd., Ishikawajima Inspection & Instrumentation Co., LtdInventors: Akihiro Sato, Kiyofumi Ishikawa, Hiroyuki Miyazawa, Hiroto Yamaoka, Yasuhiro Aoki
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Patent number: 6114524Abstract: The present invention relates to a process for producing a compound represented by the formula (II): ##STR1## wherein X is a halogen atom, each of A.sup.1, A.sup.2 and A.sup.3 are the same or different and are selected from a carbon atom or a nitrogen atom, provided that at least A.sup.1, A.sup.2, or A.sup.3 is a nitrogen atom. Each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and are selected from a hydrogen atom, a lower alkyl group, a cyano group, a carboxyl group, a lower alkoxycarbonyl group, a halogen atom, and a nitro group. It is also provided that where R.sup.1 and R.sup.2 are adjacent to each other, R.sup.1 and R.sup.2 may be combined with each other to form a 5- or 6-membered ring which may carry on the ring thereof one substituent selected from the group consisting of a lower alkyl group, a nitrile group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a halogen atom, a nitro group, and an amino-(lower alkyl) group.Type: GrantFiled: June 8, 1999Date of Patent: September 5, 2000Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Shigemitsu Okada, Ryosuke Ushijima, Kiyofumi Ishikawa
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Patent number: 5714479Abstract: A heteroaromatic ring-fused cyclopentene derivative of the formula: ##STR1## wherein the variables are as defined in the specification; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: February 20, 1996Date of Patent: February 3, 1998Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Toshio Nagase, Toshiaki Mase, Takashi Hayama, Masaki Ihara, Masaru Nishikibe, Mitsuo Yano
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Patent number: 5691315Abstract: The invention relates to compounds which are antagonists of endothelin, to processes for their preparation, and to their use as pharmaceuticals. The compounds of the invention are Useful in the treatment of hypertension, pulmonary hypertension, Reynaud's disease, myocardial infarction, angina pectoris, acute renal failure, cerebral infarction, cerebral vasospasm, arteriosclerosis, asthma, endotoxin shock, endotoxin-induced multiple organ failure or disseminated intravascular coagulation, and/or cyclosporin-induced renal failure or hypertension.Type: GrantFiled: June 26, 1995Date of Patent: November 25, 1997Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano
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Patent number: 5614498Abstract: Peptides having the formula: ##STR1## inhibit the binding of endothelin to its ET.sub.B receptor and are useful in treating diseases associated with excess production or secretion of endothelin.Type: GrantFiled: September 16, 1992Date of Patent: March 25, 1997Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takeshi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano, Masaru Nishikibe
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Patent number: 5498717Abstract: This invention relates to novel 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols, a process for preparing the 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols reioselectively and in a high yield utilizing the Bischler-Napieralski reaction, a process for synthesizing 6,7-dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ols via the compounds, and use of the 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols for preparation of the 6,7-dialkoxy-1, 2,3,4-tetrahydroisoquinolin-8-ols.It is possible according to this invention, to obtain the 6,7 -dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ols, which have hitherto been difficult to synthesize, via the 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols in a high yield.Type: GrantFiled: August 10, 1994Date of Patent: March 12, 1996Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takashi Hayama
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Patent number: 5496928Abstract: Peptides having the formula: ##STR1## inhibit the binding of endothelin and are useful in treating diseases associated with excess production or secretion of endothelin.Type: GrantFiled: April 20, 1994Date of Patent: March 5, 1996Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano, Masaru Nishikibe
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Patent number: 5496422Abstract: The corrosion resistance inherent in stainless steel is further improved by a cladding layer provided on the surface thereof. The cladding layer is formed of a coating material which is applied onto the surface of the stainless steel and, then, burnt to be fused by laser beams. The coating material contains a larger amount of Cr than that of the stainless steel. The thus fused material and a fused portion of the stainless steel are mixed with each other to form the cladding layer of remarkable corrosion resistance due to a larger amount of Cr contained therein. The formation of the cladding layer on the inner surface of a small diameter pipe is enabled by a coating film shaping device which has a jig for shaping the applied material into a film of a uniform thickness and by a laser irradiation torch which has an arrangement for emitting the laser means radially outward from the inside of the pipe.Type: GrantFiled: October 31, 1994Date of Patent: March 5, 1996Assignee: Ishikawajima-Harima Heavy Industries Co., Ltd.Inventors: Norio Morishige, Kenji Hirano, Kiyofumi Ishikawa, Shuji Furuya
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Patent number: 5494897Abstract: A peptide derivative of the formula: ##STR1## is a novel compound having antagonism against three endothelin isopeptides. A 2-cyanotryptophan or a protected compound thereof, is an intermediate for the preparation of the endothelin antagonist.Type: GrantFiled: June 3, 1994Date of Patent: February 27, 1996Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Masaki Ihara, Mitsuo Yano
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Patent number: 5470833Abstract: Peptides having the formula: ##STR1## inhibit the binding of endothelin to its receptor and are useful in treating diseases associated with excess production or secretion of endothelin.Type: GrantFiled: March 14, 1994Date of Patent: November 28, 1995Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano
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Patent number: 5446164Abstract: This invention relates to novel 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols, a process for preparing the 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols reioselectively and in a high yield utilizing the Bischler-Napieralski reaction, a process for synthesizing 6,7-dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ols via the compounds, and use of the 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols for preparation of the 6,7-dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ols.It is possible, according to this invention, to obtain the 6,7-dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ols, which have hitherto been difficult to synthesize, via the 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ols in a high yield.Type: GrantFiled: February 22, 1994Date of Patent: August 29, 1995Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takashi Hayama
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Patent number: 5444152Abstract: Peptides having the formula ##STR1## inhibit the binding of endothelin to its receptor and are useful in treating diseases associated with excess production or secretion of endothelin.Type: GrantFiled: March 21, 1994Date of Patent: August 22, 1995Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano
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Patent number: 5426278Abstract: A laser irradiating torch device is used to apply corrosion resistant coating or other coatings to an inner surface of small diameter piping. The torch device consists basically of a torch body disposed in the rearward end of the torch device; a revolving torch head disposed in the forward end of the torch device which revolves around the central axis of the torch device; and a driving device to rotate the torch head disposed in the rearward end. A laser beam generated outside the torch device is transmitted to the torch head in an optical fiber disposed, longitudinally through the central axis, and the focal point of the laser beam can be adjusted with a lens system whose location can be adjusted in the axial direction. The transmitted laser beam is reflected radially out of the torch device with a reflection mirror, and the lens system is adjusted so that the laser beam is focused near the inner surface of the piping.Type: GrantFiled: July 12, 1993Date of Patent: June 20, 1995Assignee: Ishikawajima-Harima Heavy Industries Co., Ltd.Inventors: Kenji Hirano, Norio Morishige, Kiyofumi Ishikawa, Shuji Furuya
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Patent number: 5389620Abstract: A heteroaromatic ring-fused cyclopentene derivative of the formula: ##STR1## wherein the variables are as defined in the specification; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 14, 1993Date of Patent: February 14, 1995Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Toshio Nagase, Toshiaki Mase, Takashi Hayama, Masaki Ihara, Masaru Nishikibe, Mitsuo Yano
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Patent number: 5387292Abstract: The corrosion resistance inherent in stainless steel is further improved by a cladding layer provided on the surface thereof. The cladding layer is formed of a coating material which is applied onto the surface of the stainless steel and, then, burnt to be fused by laser beams. The coating material contains a larger amount of Cr than that of the stainless steel. The thus fused material and a fused portion of the stainless steel are mixed with each other to form the cladding layer of remarkable corrosion resistance due to a larger amount of Cr contained therein. The formation of the cladding layer on the inner surface of a small diameter pipe is enabled by a coating film shaping device which has a jig for shaping the applied material into a film of a uniform thickness and by a laser irradiation torch which has an arrangement for emitting the laser means radially outward from the inside of the pipe.Type: GrantFiled: August 24, 1992Date of Patent: February 7, 1995Assignee: Ishikawajima-Harima Heavy Industries Co., Ltd.Inventors: Norio Morishige, Kenji Hirano, Kiyofumi Ishikawa, Shuji Furuya
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Patent number: 5380921Abstract: There are provided novel aminophosphonic acid derivatives of the general formula [I]: ##STR1## wherein n is an integer of 2 or 3; R.sup.1 is a phenyl, naphthyl, indolyl, benzothienyl, benzofuryl or benzoxazolyl group which may have 1 to 3 substituents selected from the group consisting of hydroxyl and lower alkyloxy groups, or a hydrogen atom; R.sup.2 is a lower alkyl group, a benzyl group, a 4-hydroxybenzyl group, a 3-indolylmethyl group or a .beta.-phenethyl group; and A is an optional residue of an amino acid selected from the group consisting of tryptophane, tyrosine, phenylalanine, homophenylalanine, naphthylalanine or N.sup..omega. -nitroarginine, and their pharmaceutically acceptable salts. The compounds according to the present invention and their pharmaceutically acceptable salts exhibit an inhibitory activity against endothelin-converting enzyme, and are expected to be useful as a drug treating various diseases with which endothelin is concerned.Type: GrantFiled: May 4, 1993Date of Patent: January 10, 1995Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Matsuyama, Kazuhito Noguchi, Mitsuo Yano
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Patent number: 5362736Abstract: Novel isoquinoline derivatives represented by formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X.sup.1 and X.sup.2 are as defined in the specification, have an anti-arrhythmic activity and bradycardiac activity and are effective for the treatment of arrhythmia, myocardiac infarction or angina pectoris.Type: GrantFiled: February 25, 1992Date of Patent: November 8, 1994Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takashi Hayama, Masaru Nishikibe, Mitsuo Yano
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Patent number: 5352704Abstract: A guanidinobenzene derivative represented by the formula (I): ##STR1## wherein R.sup.1 represents a substituent selected from the group consisting of a phenyl group substituted by an amidino group and a naphthyl group substituted by an amidino group, and salt thereof; a process for the production thereof; and an antiviral pharmaceutical composition comprising the compound.Type: GrantFiled: October 20, 1992Date of Patent: October 4, 1994Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Akira Okuyama, Kyozo Naito, Hidetoshi Ogino, Toshio Nagase, Kiyofumi Ishikawa, Nobuo Tanaka
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Patent number: 5196272Abstract: The corrosion resistance inherent in stainless steel is further improved by a cladding layer provided on the surface thereof. The cladding layer is formed of a coating material which is applied onto the surface of the stainless steel and, then, burnt to be fused by laser beams. The coating material contains a larger amount of Cr than that of the stainless steel. The thus fused material and a fused portion of the stainless steel are mixed with each other to form the cladding layer of remarkable corrosion resistance due to a larger amount of Cr contained therein. The formation of the cladding layer on the inner surface of a small diameter pipe is enabled by a coating film shaping device which has a jig for shaping the applied material into a film of a uniform thickness and by a laser irradiation torch which has an arrangement for emitting the laser means radially outward from the inside of the pipe.Type: GrantFiled: July 15, 1992Date of Patent: March 23, 1993Assignee: Ishikawajima-Harima Heavy Industries Co., Ltd.Inventors: Norio Morishige, Kenji Hirano, Kiyofumi Ishikawa, Shuji Furuya