Patents by Inventor Kiyosei Takasu
Kiyosei Takasu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8809567Abstract: The invention relates to a method for producing silyl enol ether compound (3) by reacting ketone or aldehyde compound (1) with allylsilane compound (2) in the presence of a base and 0.00001 to 0.5 equivalents of an acid catalyst relative to ketone or aldehyde compound (1).Type: GrantFiled: March 3, 2011Date of Patent: August 19, 2014Assignee: Kyoto UniversityInventors: Kiyosei Takasu, Yoshiji Takemoto, Kei Kurahashi
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Publication number: 20130053567Abstract: The invention relates to a method for producing silyl enol ether compound (3) by reacting ketone or aldehyde compound (1) with allylsilane compound (2) in the presence of a base and 0.00001 to 0.5 equivalents of an acid catalyst relative to ketone or aldehyde compound (1).Type: ApplicationFiled: March 3, 2011Publication date: February 28, 2013Applicant: KYOTO UNIVERSITYInventors: Kiyosei Takasu, Yoshiji Takamoto, Kei Kurahashi
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Patent number: 8193224Abstract: The present invention is to provide a medicinal composition for preventing or treating parasitic protozoan infections, having a high selective toxicity against parasitic protozoan infection, and a superior preventive or treating effect.Type: GrantFiled: September 30, 2005Date of Patent: June 5, 2012Assignees: Fujifilm CorporationInventors: Masataka Ihara, Kiyosei Takasu, Khanitha Pudhom, Hiroshi Kitaguchi, Masayuki Kawakami, Kozo Sato
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Patent number: 7795285Abstract: The present invention is to provide an anti-trypanosomiasis agent having a high selective toxicity, and high preventing or treating effect against trypanosomiasis, comprising a compound shown by the following general formula (1) as an active ingredient (wherein R1 and R2 each independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, C1-5 alkyl group, C1-5 alkoxy group, C5-8 aryl group, C5-8 aryloxy group, C2-6 alkoxycarbonyl group or C2-6 alkylaminocarbonyl group, and may be bound to each other; R3, R4, and R5 each independently represents a C1-5 alkyl group or C5-8 aryl group; R6 and R7 each independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, C1-8 alkyl group, C1-5 alkoxy group, C5-8 aryl group, C5-8 aryloxy group, or C2-6 alkoxycarbonyl group, and may be bound to each other; Y and Z each independently represents an atom group necessary to form a 5- or 6-membered heterocycle; m and n each represent 0 or 1; Q represents a physiologically acceptabType: GrantFiled: September 29, 2005Date of Patent: September 14, 2010Assignees: Fujifilm CorporationInventors: Masataka Ihara, Kiyosei Takasu, Khanitha Pudhom, Hiroshi Kitaguchi, Masayuki Kawakami, Kozo Sato
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Publication number: 20100113789Abstract: The present invention is to provide a medicinal composition for preventing or treating parasitic protozoan infections, having a high selective toxicity against parasitic protozoan infection, and a superior preventive or treating effect.Type: ApplicationFiled: September 30, 2005Publication date: May 6, 2010Applicants: FUJIFILM CORPORATIONInventors: Masataka Ihara, Kiyosei Takasu, Khanitha Pudhom, Hiroshi Kitaguchi, Masayuki Kawakami, Kozo Sato
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Publication number: 20090076067Abstract: The object of the invention is to provide pharmaceutical composition that can be used as a therapeutic and/or prophylactic agent. Particularly, the pharmaceutical composition of the invention has significant therapeutic effect and survival benefit for the disease caused by parasitic protozoa, and selective toxicity against the causative protozoa. The pharmaceutical composition comprises a compound represented by general formula (1). Particularly, the invention relates to a composition that is an effective therapeutic/prophylactic agent for malaria, leishmania, African sleeping sickness, Chagas disease, toxoplasmosis lymphatic filariasis, babesiosis, and coccidiosis, and a novel compound contained therein.Type: ApplicationFiled: June 5, 2006Publication date: March 19, 2009Applicants: JAPAN SCIENCE AND TECHNOLOGY AGENCY, FUJIFILM CORPORATIONInventors: Masataka Ihara, Kiyosei Takasu, Kanitha Pudhom, Masayuki Kawakami, Hiroshi Kitaguchi, Kouzou Satou
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Publication number: 20090036437Abstract: The purpose of the present invention is therefore to provide a pharmaceutical composition, especially that for the treatment and/or prevention of parasitic infection by protozoa, which has a high therapeutic effect and selective toxicity or a life-prolongation effect for the parasitic infection by protozoa.Type: ApplicationFiled: February 7, 2006Publication date: February 5, 2009Applicants: JAPAN SCIENCE AND TECHNOLOGY AGENCY, FUJIFILM CORPORATIONInventors: Masataka Ihara, Kiyosei Takasu, Masayuki Kawakami, Hiroshi Kitaguchi, Kouzou Satou
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Publication number: 20080051598Abstract: The prior art required specialized substrates or reaction conditions to be used to manufacture polysubstituted cyclobutane compounds and polysubstituted cyclobutene compounds, and the method had poor generality. The type or quantity of the catalyst or solvent used was also problematic in the industrial manufacture of polysubstituted cyclobutane compounds. The present invention provides a method for manufacturing a polysubstituted cyclobutane compound with high stereoselectivity that has low environmental load (is ecologically advantageous) and is applicable to industrial manufacturing from the standpoint of operation, substrate generality, catalyst, solvent, and efficiency. A polysubstituted cyclobutane, a cyclobutene, and a bicyclo[4.2.Type: ApplicationFiled: July 22, 2004Publication date: February 28, 2008Inventors: Kiyosei Takasu, Masataka Ihara, Kazato Inenaga
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Publication number: 20080045574Abstract: The present invention is to provide an anti-trypanosomiasis agent having a high selective toxicity, and high preventing or treating effect against trypanosomiasis, comprising a compound shown by the following general formula (1) as an active ingredient (wherein R1 and R2 each independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, C1-5 alkyl group, C1-5 alkoxy group, C5-8 aryl group, C5-8 aryloxy group, C2-6 alkoxycarbonyl group or C2-6 alkylaminocarbonyl group, and may be bound to each other; R3, R4, and R5 each independently represents a C1-5 alkyl group or C5-8 aryl group; R6 and R7 each independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, C1-8 alkyl group, C1-5 alkoxy group, C5-8 aryl group, C5-8 aryloxy group, or C2-6 alkoxycarbonyl group, and may be bound to each other; Y and Z each independently represents an atom group necessary to form a 5- or 6-membered heterocycle; m and n each represent 0 or 1; Q represents a physiologically acceptaType: ApplicationFiled: September 29, 2005Publication date: February 21, 2008Applicants: JAPAN SCIENCE AND TECHNOLOGY AGENCY, FUJI PHOTO FILM CO., LTD.Inventors: Masataka Ihara, Kiyosei Takasu, Khanitha Pudhom, Hiroshi Kitaguchi, Masayuki Kawakami, Kozo Sato
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Publication number: 20060252800Abstract: The present invention is to provide a new anti-leishmania agent with fewer side effects, having a high cell proliferation-inhibiting effect to leishamia protozoa, and also easy to manufacture at a low cost. A compound wherein a heterocycle with a conjugated system and a nitrogen atom and a heterocycle with a nitrogen atom and a sulfur atom are bound by a carbon chain with an ethylene group, that is a compound wherein a specific 5- to 8-membered heterocyclic ring and a specific 5- to 8-membered heterocycle having a conjugated system are bound via a vinylene group, more particularly a specific rhodacyanine dye compound is used as an active ingredient of the anti-leishmania agent.Type: ApplicationFiled: April 30, 2004Publication date: November 9, 2006Inventors: Masataka Ihara, Kiyosei Takasu, Hiroki Terauchi, Setsuko Sekita, Marii Takahashi
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Patent number: 6710074Abstract: An object of the present invention is to provide a novel compound having antimalarial acitivity and an antimalarial agent containing the novel compound as an active component. An antimalarial agent containing 12-hidroxy-2-(1-methoxy-carbonylethyl)-5-oxo-10,11,13-trioxatricyclo[7.2.0.01,6]tridecane represented by a following formula (II) as an active agent is prepared.Type: GrantFiled: August 30, 2002Date of Patent: March 23, 2004Assignee: Japan Science and Technology CorporationInventors: Masataka Ihara, Kiyosei Takasu, Yusuke Wataya, Hye-Sook Kim
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Publication number: 20030078291Abstract: An object of the present invention is to provide a novel compound having antimalarial acitivity and an antimalarial agent containing the novel compound as an active component. An antimalarial agent containing 12-hidroxy-2-(1-methoxy-carbonylethyl)-5-oxo-10,11,13-trioxatricyclo[7.2.0.01,6]tridecane represented by a following formula (II) as an active agent is prepared.Type: ApplicationFiled: August 30, 2002Publication date: April 24, 2003Inventors: Masataka Ihara, Kiyosei Takasu, Yusuke Wataya, Hye-Sook Kim