Abstract: A production method of an optically active ?-amino acid represented by the formula (I) wherein each symbol is as defined in the specification, which includes reacting a compound represented by the formula (II) with a lithium amide represented by the formula (III) in the presence of a compound represented by the formula (IV).

Abstract: A production method of an optically active &bgr;-amino acid represented by the formula (I) 1

Abstract: Tires each having a tread pattern comprising sub-grooves diagonally disposed in the same direction are fitted on the left- and right-hand sides of an automobile such that imaginary lines extending respectively from the sub-grooves of the left- and right-hand tires of the same axles intersect each other on the front side of the automobile for the dry road running, while the imaginary lines intersect each other on the rear side of the automobile for the wet road running.

Abstract: Pneumatic tire characterized in the edge of each block formed on a tire tread surface is chamfered to a curve surface connecting to the tread surface in a curve form.

Abstract: This invention relates to a pneumatic tire equipped on its tire tread surface with a plurality of main grooves extending in a tire circumferential direction and transverse grooves extending from the center portion to shoulder portions while crossing the main grooves. The radius r of an approximate arc approximating to the ground contact front edge line of the tire tread surface has a relation r.ltoreq.2w with the ground contact width w, the direction of the main grooves has an angle within a range of .+-.10.degree. with respect to the normal of the approximate arc and the main grooves are disposed also in the shoulder portions outside 40 % from the center of the tire tread surface besides the center portion.

Abstract: An azacyclooctadiene compound having the formula (1) or a pharmacologically acceptable salt thereof is novel and useful as an anti-tumor agent. ##STR1## in which R1 is --CH2R, R being hydrogen, --COCH3, --OH, --NH2, --COOH or --OCOCH3, or may form --CH2--X--Y-- together with R2; R2 is hydrogen, an alkyl having 1 to 4 carbon atoms or --COR10, R10 being hydrogen, an alkyl having 1 to 4 carbon atoms, --OR11 or --NHR11, R11 being an alkyl having 1 to 4 carbon atoms, or may form --CH2--X--Y-- together with R1; R3, R4 and R5 each are hydrogen or methyl; R6 and R7 each are hydrogen or may form the direct bond to each other; R8 is hydrogen or may form the direct bond to R7; and R9 is hydrogen, --N3, --NH2, --OCH3 or .dbd.0; X being oxygen or --NZ--, Z being hydrogen, methyl, --COCH3, --CH2COOH, --CO--CH.dbd.CH2, --CO--CH.dbd.CH--CH3, --CH2C6H5, --CH2OH, --CH2OCOCH3 or --CH2--COOC(CH3)3, Y being --SC--, --CO-- or --CH2--.