Abstract: To provide an optical element in which an electrode is directly formed on an LN substrate, and a drift phenomenon is suppressed. In an optical element including: a substrate made of lithium niobate crystals; and an electrode disposed on the substrate, the substrate and the electrode are in direct contact with each other, and as a contact metal disposed on a surface of the electrode where the electrode is in contact with the substrate, a metal material whose standard enthalpy of formation per coordinate bond upon oxidation is greater than a standard enthalpy of formation per coordinate bond of niobium pentoxide is used.

Abstract: Provided are methods for culturing a cancer stem cell-derived tissue, which comprise the step of three-dimensionally culturing a cancer stem cell-derived tissue after treating it with a therapeutic agent for diseases. The culture methods of the present disclosure enable the construction of cell clusters analogous to therapeutic agent-resistant tissues which are characteristically seen in tissues of patients who have actually been administered with a therapeutic agent for diseases. The cell clusters of the present disclosure are useful for elucidating the mechanism for acquiring anticancer agent resistance, identifying a therapeutic target therefor, or screening for a therapeutic agent. The preferred disease in the present disclosure is cancer.

Abstract: To provide an optical element in which an electrode is directly formed on an LN substrate, and a drift phenomenon is suppressed. In an optical element including: a substrate made of lithium niobate crystals; and an electrode disposed on the substrate, the substrate and the electrode are in direct contact with each other, and as a contact metal disposed on a surface of the electrode where the electrode is in contact with the substrate, a metal material whose standard enthalpy of formation per coordinate bond upon oxidation is greater than a standard enthalpy of formation per coordinate bond of niobium pentoxide is used.

Abstract: A device for observing a specimen, such as a charged particle beam device exemplified by a scanning electron microscope and a transmission electron microscope in which an operator can specify minute bubbles with high contrast in a charged particle beam image of a liquid subjected to processing of generating bubbles, using a phenomenon in which contrast as high as an operator can specify minute bubbles is provided in a charged particle beam image of a specimen including an ionic liquid and a liquid subjected to processing of generating bubbles, thus making it possible to recognize minute bubbles in a liquid.

Abstract: Methods that involve detection of a DSG3 protein for diagnosing cancer are disclosed. In lung cancer, the expression of DSG3 was found to be enhanced at very high frequency at the gene level and protein level. Methods of the present invention can be carried out using an antibody that recognizes a DSG3 protein. Pharmaceutical compositions, cell growth inhibitors, and anticancer agents containing a DSG3-binding antibody as an active ingredient are also disclosed. Methods of inducing cell damage in DSG3-expressing cells and methods of suppressing proliferation of DSG3-expressing cells by contacting the DSG3-expressing cells with DSG3-binding antibodies are also disclosed.

Abstract: Disclosed is an antibody against a secreted form of GPC3 capable of detecting a secreted form of glypican 3 (GPC3) in a test sample. It is possible to determine whether a subject suffers from cancer, in particular hepatoma. Also disclosed is an antibody against GPC as well as a cell disrupting agent and an anti-cancer agent comprising the same, which can disrupt cells, in particular cancer cells.

Abstract: A thin-plate LN optical control device includes: a thin-plate LN optical waveguide element which includes an optical waveguide formed by thermal diffusion of Ti in a substrate made of lithium niobate, and a control electrode that is formed on the substrate and is configured to control a light wave propagating through the optical waveguide, and in which at least a part of the substrate is thinned; and a housing that accommodates the thin-plate LN optical waveguide element in an air-tight sealing manner. Oxygen is contained in a filler gas inside the housing.

Abstract: A device for observing a specimen, such as a charged particle beam device exemplified by a scanning electron microscope and a transmission electron microscope in which an operator can specify minute bubbles with high contrast in a charged particle beam image of a liquid subjected to processing of generating bubbles, using a phenomenon in which contrast as high as an operator can specify minute bubbles is provided in a charged particle beam image of a specimen including an ionic liquid and a liquid subjected to processing of generating bubbles, thus making it possible to recognize minute bubbles in a liquid.

Abstract: An electron microscope includes a secondary electron detector (51) which detects an electron generated when a sample (70) is illuminated with an electron beam from an electron gun (1), a monitor (39) which displays a secondary electron image of the sample based on an output of the detector, a gas inlet device (60) which emits gas to the sample, and a gas control device (81) which controls a gas emitting amount of the gas inlet device so that a degree of vacuum in an intermediate chamber (74) in which the secondary electron detector is installed may be kept at less than a set value P1 during gas emission performed by the gas inlet device. Accordingly, a microscopic image of the sample in a gas atmosphere with use of the detector requiring application of voltage is obtained.

Abstract: A thin-plate LN optical control device includes: a thin-plate LN optical waveguide element which includes an optical waveguide formed by thermal diffusion of Ti in a substrate made of lithium niobate, and a control electrode that is formed on the substrate and is configured to control a light wave propagating through the optical waveguide, and in which at least a part of the substrate is thinned; and a housing that accommodates the thin-plate LN optical waveguide element in an air-tight sealing manner. Oxygen is contained in a filler gas inside the housing.

Abstract: Disclosed is an antibody against a secreted form of GPC3 capable of detecting a secreted form of glypican 3 (GPC3) in a test sample. It is possible to determine whether a subject suffers from cancer, in particular hepatoma. Also disclosed is an antibody against GPC as well as a cell disrupting agent and an anti-cancer agent comprising the same, which can disrupt cells, in particular cancer cells.

Abstract: Methods that involve detection of a DSG3 protein for diagnosing cancer are disclosed. In lung cancer, the expression of DSG3 was found to be enhanced at very high frequency at the gene level and protein level. Methods of the present invention can be carried out using an antibody that recognizes a DSG3 protein. Pharmaceutical compositions, cell growth inhibitors, and anticancer agents containing a DSG3-binding antibody as an active ingredient are also disclosed. Methods of inducing cell damage in DSG3-expressing cells and methods of suppressing proliferation of DSG3-expressing cells by contacting the DSG3-expressing cells with DSG3-binding antibodies are also disclosed.

Abstract: The present invention provides a solid oxide fuel cell system capable of preventing excess temperature rises while increasing overall energy efficiency. The present invention is a solid oxide fuel cell system, including: a fuel cell module, a fuel supply device, a heat storing material, and a controller which, based on power demand, increases the fuel utilization rate when output power is high and to lower it when output power is low, and changes the electrical power actually output at a delay after changing the fuel supply amount. The controller has a stored heat estimating circuit for estimating the surplus heat based on fuel supply and on power output at a delay relative thereto. When a utilizable amount of surplus heat is accumulated in the heat storage material, the fuel supply is reduced so that the fuel utilization rate increases relative to the same electrical power.

Abstract: An air filter includes a filter body configured to trap dust contained in air passing therethrough and a holding frame configured to surround an end edge of the filter body, and the holding frame is formed of a resilient material. The holding frame includes a first surface on a proximal end side in a direction of travel of air passing through the filter body, and a second surface on a distal end side in the direction of travel, and one of the first surface and the second surface is provided with a projecting portion.

Abstract: The present invention is to provide a solid oxide fuel cell capable of improving the overall energy efficiency. The present invention is directed to a solid oxide fuel cell and comprising: a fuel cell module; a fuel supply device; a combustion chamber for burning excess fuel and heating; a heat storing material, a power demand detecting sensor; a temperature detection device, and a control device for controlling so that the fuel utilization rate is high when generated power is large, and also for changing output power at a delay to the fuel supply rate; whereby the control device comprises a stored heat amount estimating circuit, and when it is estimated that a utilizable heat amount has accumulated in the heat storing material, the fuel supply rate is reduced so that the fuel utilization rate increases vs. the same generated power.

Abstract: Provided is a method for diagnosing cancer by detecting a novel cancer marker. Cancer can be diagnosed by detecting soluble glypican 3 in a test sample.

Abstract: The invention is to provide a solid oxide fuel cell system including: a fuel cell module, a fuel flow regulator unit, a first power demand detection device, a control section for controlling a fuel supply amount and setting the current value extractable from the fuel cell module, an inverter for extracting current in a range not exceeding the extractable current value, and a power state detecting sensor for detecting actual extracted current value; whereby if actual extracted current value declines, then under circumstances where power demand begins to rise in a state of extra margin in the fuel supply amount after the controller suddenly decreases the extractable current value and suddenly reduces the electrical collector, the controller increases the extractable current value at a high current rise rate of change.