Patents by Inventor Kjetil Tasken

Kjetil Tasken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220409582
    Abstract: The present invention relates to compositions and methods for treatment of cholangiocarcinoma and in particular to combination therapies comprising panobinostat compositions in combination with other cytotoxic agents, e.g. agents that potentiate the effects of panobinostat, for use in the treatment of cholangiocarcinoma. Pharmaceutical compositions comprising panobinostat and other cytotoxic agents are also provided.
    Type: Application
    Filed: September 11, 2020
    Publication date: December 29, 2022
    Inventors: Theresa AHRENS, Alexandra GADE, Eivind HOVIG, Jo KLAVENESS, Johannes LANDSKRON, Kjetil TASKEN, Tove Cecilie VIEBE
  • Publication number: 20220401444
    Abstract: The present invention provides a method of treating ALK-negative/LTK-positive cancer in a subject, comprising administering to the subject a pharmaceutically-effective dose of a linear inhibitor of ALK. The invention is of particular utility in treating multiple myeloma, including proteasome inhibitor-resistant multiple myeloma.
    Type: Application
    Filed: March 12, 2020
    Publication date: December 22, 2022
    Applicant: UNIVERSITETET I OSLO
    Inventors: Hesso FARHAN, Ludvig MUNTHE, Kjetil TASKEN, Sigrid SKANLAND, Mariaserena GILIBERTO, Fredrik HELLEM SCHJESVOLD, Christoph DRIESSEN, Lenka BESSE, Andrej BESSE
  • Patent number: 9951033
    Abstract: The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP18?) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl) amine structure.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: April 24, 2018
    Assignee: UNIVERSITETET I OSLO
    Inventors: Kjetil Tasken, Birgitte Lygren, Ellen Ostensen, Jo Klaveness
  • Publication number: 20170158657
    Abstract: The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP18?) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl) amine structure.
    Type: Application
    Filed: December 15, 2016
    Publication date: June 8, 2017
    Inventors: Kjetil Tasken, Birgitte Lygren, Ellen Ostensen, Jo Klaveness
  • Patent number: 9585880
    Abstract: The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP18?) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl) amine structure.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: March 7, 2017
    Assignee: Universitetet I Oslo
    Inventors: Jo Klaveness, Kjetil Tasken
  • Patent number: 9556111
    Abstract: The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP185) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl)amine structure.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: January 31, 2017
    Assignee: UNIVERSITETET I OSLO
    Inventors: Kjetil Tasken, Birgitte Lygren, Ellen Ostensen, Jo Klaveness
  • Publication number: 20150141456
    Abstract: The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP18?) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl) amine structure.
    Type: Application
    Filed: November 20, 2014
    Publication date: May 21, 2015
    Inventors: Jo Klaveness, Kjetil Tasken
  • Publication number: 20150133510
    Abstract: The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP185) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl)amine structure.
    Type: Application
    Filed: May 17, 2013
    Publication date: May 14, 2015
    Applicant: Universitetet I Oslo
    Inventors: Kjetil Tasken, Birgitte Lygren, Ellen Ostensen, Jo Klaveness
  • Patent number: 8153609
    Abstract: This invention provides novel 8-carbyl substituted cAMPS and a novel procedures for the preparation of 8-Br-cAMP, a key starting material.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: April 10, 2012
    Assignee: Lauras AS
    Inventors: Kjell Undheim, Kjetil Taskén, Jo Klaveness, Geir Langli, Vidar Bjørnstad
  • Patent number: 7790738
    Abstract: The present invention provides a method of treating or preventing a disorder typified by an immunodificiency (e.g. HIV), wherein the patient is administered a COX-2 inhibitor or derivative or pharmaceutically acceptable salt thereof, preferably diisopropylfluorophasphate. L-745337, rofecoxib, NS 398, SC 58125, etodolac, meloxicam, celecoxib or nimesulide, and compositions and products containing the same or use of the same in preparing medicaments and for treatment.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: September 7, 2010
    Assignee: Lauras AS
    Inventors: Kjetil Taskén, Michel Moutschen, Souad Rahmouni-Piette, Einar Martin Aandahl, Pål Aukrust, Stig S. Frøland, Christian C. Johansson, Vidar Hansson, Jo Klaveness
  • Publication number: 20080293665
    Abstract: This invention provides novel 8-carbyl substituted Camps (adenosine 3?,5?-cyclic monophosphorothioate) and a novel procedures for the preparation of 8-Br-cAMP, a key starting material.
    Type: Application
    Filed: June 20, 2005
    Publication date: November 27, 2008
    Applicant: Lauras AS
    Inventors: Kjell Undheim, Kjetil Tasken, Jo Klaveness, Geir Langli, Vidar Bjornstad
  • Publication number: 20080248008
    Abstract: A PKA I anchoring disrupting molecule or AKAP mimic, wherein said molecule or mimic is a polypeptide which comprises the following amino acid sequence: X1 X2 X3 Y A X4 X5 L A X6 X7 X8 I X9 X10 X11 X12 X13 (sequence (1)) or a peptidomimetic or analogue thereof is provided. Also provided are antibodies to the molecule, nucleic acid molecules comprising a sequence encoding the molecule and pharmaceutical compositions. A method of altering the PKA type I signalling pathway in a cell by administration of the anchoring disruption molecule or AKAP mimic, in particular to treat immunosuppressive disorders, proliferative diseases or autoimmune diseases is also provided.
    Type: Application
    Filed: September 26, 2005
    Publication date: October 9, 2008
    Inventors: Cathrine Rein Carlson, Kjetil Tasken, John Scott
  • Patent number: 7192932
    Abstract: Pharmaceutical compositions useful for treating immunosuppressive disease and containing compounds capable of inhibiting cAMP-dependent protein kinase A (PKA) as well as use of the same, are described.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: March 20, 2007
    Assignee: Lauras AS
    Inventors: Kjetil Taskén, Einar M. Aandahl, Pål Aukrust, Bjørn S. Skålhegg, Fredrik Müller, Stig Frøland, Vidar Hansson
  • Publication number: 20050250727
    Abstract: Pharmaceutical compositions useful for treating immunosuppressive disease and containing compounds capable of inhibiting cAMP-dependent protein kinase A (PKA) as well as use of the same, are described.
    Type: Application
    Filed: May 25, 2005
    Publication date: November 10, 2005
    Inventors: Kjetil Tasken, Einar Aandahl, Pal Aukrust, Bjorn Skalhegg, Fredrik Muller, Stig Froland, Vidar Hansson
  • Publication number: 20040082640
    Abstract: The present invention provides a method of treating or preventing a disorder typified by an immunodificiency (e.g. HIV), wherein the patient is administered a COX-2 inhibitor or derivative or pharmaceutically acceptable salt thereof, preferably diisopropylfluorophasphate. L-745337, rofecoxib, NS 398, SC 58125, etodolac, meloxicam, celecoxib or nimesulide, and compositions and products containing the same or use of the same in preparing medicaments and for treatment.
    Type: Application
    Filed: June 6, 2003
    Publication date: April 29, 2004
    Inventors: Kjetil Tasken, Michel Moutschen, Souad Rahmouni-Piette, Einar Martin Aandahl, P?aring;l Aukurst, Stig S Frland, Christian C Johansson, Vidar Hansson, Jo Klaveness