Abstract: The present invention relates to compositions of recombinant polynucleic acid or RNA constructs comprising a first RNA sequence, a second RNA sequence, and a linker RNA sequence, wherein the linker RNA links the first RNA sequence and the second RNA sequence. In addition, linkers that enhance the cleavage of recombinant RNA constructs are described. Also disclosed herein is the use of the compositions in treating diseases and in modulating expression of two or more genes.

Abstract: The present invention relates to compositions and methods for modulating expression of genes, comprising recombinant polynucleic acid or RNA constructs comprising a first RNA sequence encoding a gene of interest, and a second RNA sequence comprising at least two genetic elements that modulate expression of one or more target RNAs. The recombinant RNA constructs described herein induce an immune response in a human cell that is lower than the immune response induced by a corresponding recombinant RNA construct comprising the first RNA sequence encoding a gene of interest and a corresponding second RNA sequence comprising at most one of the at least two genetic elements. Also disclosed herein is the use of the compositions in treating diseases and in modulating expression of two or more genes.

Abstract: The present invention relates to a mRNA and a therapeutic composition thereof for use in a method of treating lower urinary tract symptoms.

Abstract: A vehicle body assembly includes a first door sill arrangement and a second door sill arrangement for a motor vehicle. The first door sill arrangement includes a first bodywork section, a first anchoring device for anchoring a seatbelt in the first bodywork section, and a belt tensioner for tightening the seatbelt. The belt tensioner is in operative connection with the first anchoring device. A first trim element covers the first bodywork section. The second door sill arrangement includes a second bodywork section, a second anchoring device for anchoring the seatbelt in the second bodywork section and a second trim element, which covers the second bodywork section.