Patents by Inventor Klara M. Schenk

Klara M. Schenk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer
    Patent number: 5948909
    Abstract: The invention relates to a method for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer, characterized in that a substantially pure enantiomer of the general formula ##STR1## is prepared from a compound of the general formula ##STR2## wherein the variable are as defined as in claim 1. The method comprises the following successive reaction steps:(i) reaction with a substantially enantiomerically pure compound of the general formula ##STR3## wherein Z, R.sub.3 and R.sub.4 are defined as in claim 1; (ii) subjection of the compound formed to a deprotection/ring-closure reaction;(iii) optionally deprotection of the hydroxy group of the ring-closed product.The invention further relates to enantiomerically pure intermediates, the preparation of these intermediates and the preparation of a starting compound.
    Type: Grant
    Filed: January 22, 1997
    Date of Patent: September 7, 1999
    Assignee: Duphar International Research B.V.
    Inventors: Nicolaas Buizer, Chris G. Kruse, Klara M. Schenk, Belal Shadid