Patents by Inventor Klaus-Dieter Bremm

Klaus-Dieter Bremm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-Heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein
    Patent number: 7192971
    Abstract: Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: March 20, 2007
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jürgen Stoltefuss, Michael Lörges, Gunter Schmidt, Arndt Brandes, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
  • 4-heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein
    Publication number: 20060069112
    Abstract: Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.
    Type: Application
    Filed: October 25, 2005
    Publication date: March 30, 2006
    Applicant: Bayer Aktiengesellschaft
    Inventors: Jürgen Stoltefuß, Michael Lörges, Gunter Schmidt, Arndt Brandes, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
  • 4-heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein
    Patent number: 6958346
    Abstract: Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: October 25, 2005
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jürgen Stoltefuss, Michael Lögers, Gunter Schmidt, Arndt Brandes, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
  • 4-Phenyltetrahydrochinoline utilized as an inhibitor of the cholesterol ester transfer protein
    Patent number: 6897317
    Abstract: The tetrahydroquinolines can be prepared by condensing appropriately substituted tetrahydroquinoline aldehydes with suitable substances and subsequently varying the substituents present by customary methods. The tetrahydroquinolines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis and dyslipidaemias.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: May 24, 2005
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Schmidt, Jürgen Stoltefuss, Michael Lögers, Arndt Brandes, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
  • 4-Phenyltetrahydrochinoline utilized as an inhibitor of the cholesterol ester transfer protein
    Publication number: 20030232990
    Abstract: The tetrahydroquinolines can be prepared by condensing appropriately substituted tetrahydroquinoline aldehydes with suitable substances and subsequently varying the substituents present by customary methods. The tetrahydroquinolines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis and dyslipidaemias.
    Type: Application
    Filed: March 31, 2003
    Publication date: December 18, 2003
    Applicant: Bayer Aktiengesellschaft
    Inventors: Gunter Schmidt, Jurgen Stoltefuss, Michael Logers, Arndt Brandes, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
  • Substituted tetrahydronaphthaline and analogous compounds
    Patent number: 6586613
    Abstract: Substituted tetrahydro-naphthalenes and analogous compounds are prepared by reducing or condensing appropriate functional substituents in substituted tetrahydro-naphthalenes and analogous compounds by customary methods and converting functional groups in this manner into the desired groups. The compounds according to the invention are suitable for use as active compounds in pharmaceuticals, in particular in pharmaceuticals for treating arteriosclerosis and also dyslipidaemias.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: July 1, 2003
    Assignee: Bayer Aktiengellschaft
    Inventors: Arndt Brandes, Michael Lögers, Jürgen Stoltefuss, Gunter Schmidt, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt, Stefan Antons, Holger Paulsen, Stephan Nicholas Müller, Paul Naab, Carsten Schmeck
  • 4-phenyltetrahydrochinoline utilized as an inhibitor of the cholesterol ester transfer protein
    Patent number: 6562976
    Abstract: The tetrahydroquinolines can be prepared by condensing appropriately substituted tetrahydroquinoline aldehydes with suitable substances and subsequently varying the substituents present by customary methods. The tetrahydroquinolines are suitable as active compounds in medicaments, in particular in medicaments. for the treatment of arteriosclerosis and dyslipidaemias.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: May 13, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Schmidt, Jürgen Stoltefuss, Michael Lögers, Arndt Brandes, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
  • 4-phenyltetrahydrochinoline utilized as an inhibitor of the cholesterol ester transfer protein
    Publication number: 20020165252
    Abstract: The tetrahydroquinolines can be prepared by condensing appropriately substituted tetrahydroquinoline aldehydes with suitable substances and subsequently varying the substituents present by customary methods. The tetrahydroquinolines are suitable as active compounds in medicaments, in particular in medicaments. for the treatment of arteriosclerosis and dyslipidaemias.
    Type: Application
    Filed: April 15, 2002
    Publication date: November 7, 2002
    Applicant: Bayer Aktiengesellschaft
    Inventors: Gunter Schmidt, Jurgen Stoltefuss, Michael Logers, Arndt Brandes, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
  • Hetero-tetrahydroquinolines
    Publication number: 20020062024
    Abstract: Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.
    Type: Application
    Filed: October 31, 2001
    Publication date: May 23, 2002
    Inventors: Jurgen Stoltefuss, Michael Logers, Gunter Schmidt, Arndt Brandes, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
  • 4-heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein
    Patent number: 6387929
    Abstract: Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: May 14, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jürgen Stoltefuss, Michael Lögers, Gunter Schmidt, Arndt Brandes, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
  • Tetrahydroquinolines
    Publication number: 20020042515
    Abstract: The tetrahydroquinolines can be prepared by condensing appropriately substituted tetrahydroquinoline aldehydes with suitable substances and subsequently varying the substituents present by customary methods. The tetrahydroquinolines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis and dyslipidaemias.
    Type: Application
    Filed: June 4, 2001
    Publication date: April 11, 2002
    Inventors: Gunter Schmidt, Jurgen Stoltefuss, Michael Logers, Arndt Brandes, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
  • Tetrahydroquinolines, processes for their preparation, pharmaceutical compositions containing them, and their use to prevent or treat hyperlipoproteinaemia
    Patent number: 6291477
    Abstract: The tetrahydroquinolines can be prepared by condensing appropriately substituted tetrahydroquinoline aldehydes with suitable substances and subsequently varying the substituents present by customary methods. The tetrahydroquinolines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis and dyslipidaemias.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: September 18, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Schmidt, Jürgen Stoltefuss, Michael Lögers, Arndt Brandes, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
  • Sugar-modified cytostatics
    Patent number: 6271342
    Abstract: The invention relates to cytostatics which, by modification with sugar, are tumor-specific. Suitable spacers ensure serum stability and at the same time an intracellular action.
    Type: Grant
    Filed: September 25, 1997
    Date of Patent: August 7, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Georg Lerchen, Karsten von dem Bruch, Uwe Petersen, Jörg Baumgarten, Norbert Piel, Horst-Peter Antonicek, Walter Weichel, Michael Sperzel, Klaus Dieter Bremm
  • Cycloalkano-pyridines
    Patent number: 6207671
    Abstract: The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the cycloalkano-pyridine alcohols type with suitable bromine compounds, and optionally varying the functional groups accordingly. The cycloalkanopyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of hypertipoproteinaemia and arteriosclerosis.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: March 27, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Schmidt, Arndt Brandes, Rolf Angerbauer, Michael Lögers, Matthias Müller-Gliemann, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt, Joachim Schuhmacher, Henry Giera, Holger Paulsen, Paul Naab, Michael Conrad, Jürgen Stoltefuss
  • 5-Hydroxyalkyl substituted phenyls and their use in medicaments for the treatment of arteriosclerosis and hyperlipoproteinaemia
    Patent number: 6121330
    Abstract: The novel 5-hydroxy-alkyl-substituted phenyls are prepared by either reacting the corresponding benzaldehydes with the Grignard compounds and subsequently reducing the other functional groups or by reducing the corresponding benzoic esters by customary methods to give the corresponding hydroxyl compounds. The 5-hydroxy-alkyl-substituted phenyls are suitable for use as active compounds in medicaments, in particular for the treatment of dyslipidaemia.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: September 19, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Matthias Muller-Gliemann, Rolf Angerbauer, Arndt Brandes, Michael Logers, Carsten Schmeck, Gunter Schmidt, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
  • Cycloalkano-pyridines
    Patent number: 6069148
    Abstract: The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the cycloalkano-pyridine alcohols type with suitable bromine compounds, and optionally varying the functional groups accordingly. The, cycloalkanopyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of hyperlipoproteinaemia and arteriosclerosis.
    Type: Grant
    Filed: July 8, 1997
    Date of Patent: May 30, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Schmidt, Arndt Brandes, Rolf Angerbauer, Michael Logers, Matthias Muller-Gliemann, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt, Joachim Schuhmacher, Henry Giera, Holger Paulsen, Paul Naab, Michael Conrad, Jurgen Stoltefuss
  • Heteroatom-containing benzocyclopentane-oxazolidinones
    Patent number: 6069160
    Abstract: The invention relates to heteroatom-containing benzocyclopentaneoxazolidinones, to processes for their preparation and their use as medicaments, especially as antibacterial medicaments.
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: May 30, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Andreas Stolle, Dieter Habich, Stephan Bartel, Bernd Riedl, Martin Ruppelt, Hanno Wild, Rainer Endermann, Klaus-Dieter Bremm, Hein-Peter Kroll, Harald Labischinski, Klaus Schaller, Hans-Otto Werling
  • Bicyclic-fused pyridines
    Patent number: 6063788
    Abstract: Bicyclic-fused pyridines are prepared by introducing the appropriate side chain by reaction of the corresponding aldehydes with the aid of Wittig or Grignard reagents. The bicyclic-fused pyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosi.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: May 16, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Arndt Brandes, Michael Logers, Gunter Schmidt, Rolf Angerbauer, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt, Joachim Schuhmacher
  • 7-isoindolinyl-quinolone derivatives and 7-isoindolinyl-naphthyridone derivatives
    Patent number: 6018054
    Abstract: The invention relates to intermediate compounds for preparing novel quinolone derivatives- and naphthyridone derivatives which are substituted in the 7-position by a partially hydrogenated isoindolinyl ring, to processes for their preparation and to antibacterial agents and feed additives containing them.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: January 25, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Philipps, Stephan Bartel, Andreas Krebs, Uwe Petersen, Thomas Schenke, Klaus-Dieter Bremm, Rainer Endermann, Karl Georg Metzger, Burkhard Mielke
  • Rapid DNA test for detecting quinolone-resistant Staphylococcus aureus pathogens in clinical material
    Patent number: 6015666
    Abstract: The invention describes starter oligonucleotide (primers), DNA probes and test methods for rapidly detecting quinolone-resistant Staphylococcus aureus pathogens in clinical sample material.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 18, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Springer, Klaus-Dieter Bremm, Rainer Endermann