Patents by Inventor Klaus-Dieter Kuhn
Klaus-Dieter Kuhn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20060293407Abstract: A polymethylmethacrylate bone cement with a liquid monomer component and a solid component contains in the monomer liquid, for example, 0.001-1.00 mass percent of a dye or dye mixture that is insoluble or poorly soluble in methacrylic acid methylester and, for example, 0.001-2.00 mass percent of a synthetically produced, protein-free, hydrophobic, low molecular or oligomeric solubilizer for the dye or dye mixture. The solubilizer preferably is liquid or pasty at room temperature. The monomer liquid is translucent at room temperature. Preferably, 0.001-1.00 mass percent of a dye or dye mixture that is insoluble or poorly soluble in methacrylic acid methylester and, preferably, 0.001-2.00 mass percent of a synthetically produced, protein-free, hydrophobic, low molecular or oligomeric solubilizer that is liquid or pasty at room temperature are homogeneously dissolved in the polymethacrylate or polymethylacrylate of the powder component.Type: ApplicationFiled: June 6, 2006Publication date: December 28, 2006Applicant: HERAEUS KULZER GMBHInventors: Klaus-Dieter Kuhn, Sebastian Vogt
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Publication number: 20060292199Abstract: A PMMA bone cement containing an antibiotic/antibiotics is described which is characterized in that, in the powder component, 0.1-5.0% by weight of water soluble, glasstype antibiotic/antibiotics granules with a particle diameter in the region of 50-1000 ?m are contained which are built up of glass-type antibiotic/antibiotics primary particles bonded to each other which have a particle diameter in the region of 1-70 ?m.Type: ApplicationFiled: September 23, 2005Publication date: December 28, 2006Applicant: HERAEUS KULZER GMBHInventors: Klaus-Dieter Kuhn, Sebastian Vogt
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Publication number: 20060171986Abstract: An antibiotic coating of implants is described, which is characterized in that the coating comprises at least one saturated, organic, hydrophobic, low molecular matrix former whose melting point is in the temperature range of 45° C. to 100° C., in which a low molecular, hydrophobic additive is dissolved and that an antibiotic/antibiotics is/are suspended in the mixture of matrix former and additive and/or in which an antibiotic/antibiotics miscible with a mixture of matrix former and additive is/are dissolved.Type: ApplicationFiled: January 19, 2006Publication date: August 3, 2006Applicant: Heraeus Kulzer GmbHInventors: Klaus-Dieter Kuhn, Sebastian Vogt, Matthias Schnabelrauch
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Publication number: 20060127444Abstract: Antibiotic/s containing bone substitute material is described which is characterized in that it is composed of a compacted mixture of granules of calcium sulfate dihydrate, calcium carbonate and at least one representative of the aminoglycoside antibiotics, lincosamide antibiotics, glycopeptide antibiotics, macrolide antibiotics, ketolide antibiotics, the nitroimidazoles, the fluorochinolone antibiotics and the oxazolidinone antibiotics, the steroid antibiotics, the antiseptic agents and the fungicidal/fungistatic antibiotics which are partly or entirely sheathed with a layer of glycerol tripalmitate and/or glycerol tristearate and/or glycerol trilaurate and/or 1-hexadecyl alcohol which connects the granules with each other.Type: ApplicationFiled: December 5, 2005Publication date: June 15, 2006Applicant: Heraeus Kulzer GmbHInventors: Klaus-Dieter Kuhn, Sebastian Vogt
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Patent number: 7030093Abstract: The invention describes an antibiotic coating for porous bodies and its use. Into the porous system of non-metallic porous bodies and of metallic porous bodies, a coating made of at least one antibiotic salt that is hardly soluble in water or in an aqueous environment from the group of the netilmicin laurate, the netilmicin myristate, the netilmicin dodecyl sulfate, the sisomicin laurate, the sisomicin myristate, the sisomicin dodecyl sulfate, the gentamicin laurate, the gentamicin myristate, the clindamycin laurate, the amikacin laurate, the amikacin myristate, the amikacin dodecyl sulfate, the kanamycin laurate, the kanamycin myristate, the kanamycin dodecyl sulfate, the tobramycin laurate, the tobramycin myristate, the tobramycin dodecyl sulfate, the ciprofloxacin myristate, the vancomycin dodecyl sulfate, the vancomycin laurate, the vancomycin myristate, the vancomycin teicoplanin and the clindamycin teicoplanin is introduced. The antibiotically coated, porous bodies are used as implants.Type: GrantFiled: June 20, 2003Date of Patent: April 18, 2006Assignee: HERAEUS Kulzer GmbH & Co. KGInventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kühn
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Patent number: 6984410Abstract: The invention concerns the manufacture of an antibiotic coating of elements with interconnecting microcavities, elements thus coated as well as their use. In a preferred embodiment, a homogenous solution of a gentamicin derivative in a solvent is introduced into the microcavities of non-metallic elements with interconnecting microcavities through dipping, spraying and dripping, and following evaporation or vaporization of the solvent, a layer of the gentamicin derivative is formed on the surface of the microcavities.Type: GrantFiled: August 13, 2002Date of Patent: January 10, 2006Assignee: Heraeus Kulzer GmbH & Co. KGInventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kühn
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Patent number: 6942877Abstract: A method for producing antibiotic composites is described, which is characterized in that a salt, which can be subjected to plastic deformation and which consists of at least one cationic component of a protonated antibiotics base from the groups of aminoglycoside antibiotics, the lincosamide antibiotics and the tetracycline antibiotics and of at least one anionic components from the group of organic sulfates and/or organic sulfonates and/or fatty acid esters, is used as a binding agent for the fixation of inorganic composite components and/or possibly organic composite components and possibly for the molding of the composites while adding water, especially through pressing, extrusion, rolling, calendering and grinding processes.Type: GrantFiled: March 19, 2002Date of Patent: September 13, 2005Assignee: Heraeus Kulzer GmbH & Co. KGInventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kühn
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Patent number: 6913764Abstract: The present invention concerns an antibiotic/antibiotics preparation for resorbable and non-resorbable implants for human and veterinary medicine, for the treatment of local microbial infections in hard and soft tissue.Type: GrantFiled: March 19, 2002Date of Patent: July 5, 2005Assignee: Heraeus Kulzer GmbH & Co. KGInventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kühn
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Publication number: 20050031664Abstract: The production and use of a porous body with an antibiotic coating is described. A coating composed of at least one antibiotic salt, sparingly soluble in water or in an aqueous environment, from the group comprising fusidic acid-antibiotics, for example, fusidic acid-gentamicin, fusidic acid-sisomicin, fusidic acid-netilmicin, fusidic acid-streptomycin, fusidic acid-tobramycin, fusidic acid-spectinomycin, fusidic acid-vancomycin, fusidic acid-ciprofloxacin, fusidic acid-moxifloxacin, fusidic acid-clindamycin, fusidic acid-lincomycin, fusidic acid-tetracycline, fusidic acid-chlorotetracycline, fusidic acid-oxytetracycline, and fusidic acid-rolitetracycline is introduced into the pore system of nonmetallic porous bodies and metallic porous bodies. The antibiotically coated porous bodies are used as implants.Type: ApplicationFiled: April 23, 2004Publication date: February 10, 2005Applicant: Heraeus Kulzer GmbH & Co. KGInventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kuhn
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Publication number: 20040137065Abstract: An antibiotic polymer combination/antibiotics polymer combination that ensures the continuous release of antibiotics over a period of several days under physiological conditions, and that can be used in human and veterinary medicine.Type: ApplicationFiled: September 11, 2003Publication date: July 15, 2004Applicant: Heraeus Kulzer GmbH & Co. KGInventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kuhn
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Publication number: 20040067253Abstract: The invention relates to hardly soluble antiphlogistic salts and antiphlogistic-antibiotic pharmaceutical preparations and their use. The hardly water soluble antiphlogistic antibiotics salts have as their cationic component one of the antibiotics gentamicin, clindamycin, neomycin, streptomycin, tetracycline, doxicyline, oxytetracycline and rolitetracycline and as their anionic component one of the antiphlogistics ibuprofen, naproxen, indomethacin, dexamethasone-21-phosphate, dexamethasone-21-sulfate, triamcinolone-21-phosphate and triamcinolone-21-sulfate. The antiphlogistic antibiotics salts are used in pharmaceutical preparations as controlled-release antibiotic/antibiotics drugs.Type: ApplicationFiled: June 20, 2003Publication date: April 8, 2004Applicant: Heraeus Kulzer GmbH & Co. KGInventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kuhn
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Publication number: 20040052841Abstract: The invention describes pharmaceutical preparations with retarding active ingredient release, which consist of mixtures of powdery teicoplanin and at least one powdery, water soluble salt form of gentamicin, clindamycin, kanamycin, amikacin, tobramycin, vancomycin, moxifloxacin and ciprofloxacin and an inorganic and/or organic adjuvant. The pharmaceutical preparations are used as permanent or as temporary implants in the form of tablets, molded bodies, fibers and granules.Type: ApplicationFiled: June 20, 2003Publication date: March 18, 2004Applicant: Heraeus Kulzer GmbH & Co.KGInventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kuhn
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Publication number: 20040048786Abstract: The invention describes an antibiotic coating for porous bodies and its use. Into the porous system of non-metallic porous bodies and of metallic porous bodies, a coating made of at least one antibiotic salt that is hardly soluble in water or in an aqueous environment from the group of the netilmicin laurate, the netilmicin myristate, the netilmicin dodecyl sulfate, the sisomicin laurate, the sisomicin myristate, the sisomicin dodecyl sulfate, the gentamicin laurate, the gentamicin myristate, the clindamycin laurate, the amikacin laurate, the amikacin myristate, the amikacin dodecyl sulfate, the kanamycin laurate, the kanamycin myristate, the kanamycin dodecyl sulfate, the tobramycin laurate, the tobramycin myristate, the tobramycin dodecyl sulfate, the ciprofloxacin myristate, the vancomycin dodecyl sulfate, the vancomycin laurate, the vancomycin myristate, the vancomycin teicoplanin and the clindamycin teicoplanin is introduced. The antibiotically coated, porous bodies are used as implants.Type: ApplicationFiled: June 20, 2003Publication date: March 11, 2004Applicant: Heraeus Kulzer GmbH & Co.KGInventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kuhn
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Publication number: 20040029996Abstract: A bone cement mixture comprised of a polymer component containing an x-ray contrast medium and a monomer component, wherein the x-ray contrast medium is a polymer or copolymer having compounds of radio-opaque elements bonded thereto, or is in the form of substantially spherical polymer or copolymer particles with radio-opaque inorganic nano-particles dispersed therein.Type: ApplicationFiled: April 29, 2003Publication date: February 12, 2004Applicant: Heraeus Kulzer GmbH & Co. KGInventor: Klaus-Dieter Kuhn
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Publication number: 20030096097Abstract: The invention concerns the manufacture of an antibiotic coating of elements with interconnecting microcavities, elements thus coated as well as their use. In a preferred embodiment, a homogenous solution of a gentamicin derivative in a solvent is introduced into the microcavities of non-metallic elements with interconnecting microcavities through dipping, spraying and dripping, and following evaporation or vaporization of the solvent, a layer of the gentamicin derivative is formed on the surface of the microcavities.Type: ApplicationFiled: August 13, 2002Publication date: May 22, 2003Inventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kuhn
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Publication number: 20030049324Abstract: The invention relates to a method for the antibiotic coating of bodies with interconnecting microcavities as well as bodies coated this way and their usage.Type: ApplicationFiled: June 19, 2002Publication date: March 13, 2003Applicant: Heraeus Kulzer GmbH & Co. KGInventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kuhn
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Publication number: 20020192279Abstract: A method for producing antibiotic composites is described, which is characterized in that a salt, which can be subjected to plastic deformation and which consists of at least one cationic component of a protonated antibiotics base from the groups of aminoglycoside antibiotics, the lincosamide antibiotics and the tetracycline antibiotics and of at least one anionic components from the group of organic sulfates and/or organic sulfonates and/or fatty acid esters, is used as a binding agent for the fixation of inorganic composite components and/or possibly organic composite components and possibly for the molding of the composites while adding water, especially through pressing, extrusion, rolling, calendering and grinding processes.Type: ApplicationFiled: March 19, 2002Publication date: December 19, 2002Applicant: Heraeus Kulzer GmbH & co.KGInventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kuhn
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Publication number: 20020183265Abstract: The present invention concerns the manufacture and use of an antibiotic/antibiotics preparation for human and veterinary medicine, for the treatment of local microbial infections in hard and soft tissue.Type: ApplicationFiled: March 19, 2002Publication date: December 5, 2002Applicant: Heraues Kulzer GmbH & Co.KGInventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kuhn
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Publication number: 20020182251Abstract: The present invention concerns an antibiotic/antibiotics preparation for resorbable and non-resorbable implants for human and veterinary medicine, for the treatment of local microbial infections in hard and soft tissue.Type: ApplicationFiled: March 19, 2002Publication date: December 5, 2002Applicant: Heraues Kulzer GmbH & Co.KGInventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kuhn
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Publication number: 20020150549Abstract: The present invention relates to an antibiotic(s)-polymer combination, which under physiological conditions guarantees the continuous release of antibiotics over a period of several days and can be used in human and veterinary medicine. The invented antibiotic(s)-polymer combination is whereinin a homogeneous polymer mixture, consisting of one or more hydrophobic polymers from the groups of poly(methacrylic acid esters), the poly(acrylic acid esters) and the poly(methacrylic acid ester-co-acrylic acid esters) and one or more hydrophilic polymers from the group of polyethers, one or more slightly water-soluble antibiotics from the groups of aminoglycoside antibiotics, the lincosamide antibiotics, the tetracycline antibiotics and quinolone antibiotics, possibly an easily water-soluble antibiotic from the groups of aminoglycoside antibiotics, the lincosamide antibiotics and the tetracycline antibiotics, and possibly one or more organic adjuvants are suspended, and that this suspension forms a composite.Type: ApplicationFiled: March 19, 2002Publication date: October 17, 2002Applicant: Heraues Kulzer GmbH & Co.KGInventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kuhn