Patents by Inventor Klaus H. Nielsen

Klaus H. Nielsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of antibodies to bacterial antigens by fluorescence polarization
    Patent number: 6596546
    Abstract: In a homogeneous immunoassay, fluorophore-conjugated lipopolysaccharide derived bacterial antigens are reacted with antibodies specific for the antigens. Quantitative detection of the formation of an immune complex is obtained by measuring the change in fluorescence polarization after complex formation. The reaction occurs quickly (less than two minutes to equilibrium), and involves the addition of only one reagent to a diluted serum specimen. The absence of a solid phase separation step eliminates false positive results and increases throughput.
    Type: Grant
    Filed: September 22, 1999
    Date of Patent: July 22, 2003
    Inventors: Michael E. Jolley, Klaus H. Nielsen
  • Detection of antibodies to bacterial antigens by flourescence polarization
    Patent number: 5976820
    Abstract: In a homogeneous immunoassay, fluorophore-conjugated lipopolysaccharide derived bacterial antigens are reacted with antibodies specific for the antigens. Quantitative detection of the formation of an immune complex is obtained by measuring the change in fluorescence polarization after complex formation. The reaction occurs quickly (less than two minutes to equilibrium), and involves the addition of only one reagent to a diluted serum specimen. The absence of a solid phase separation step eliminates false positive results and increases throughput.
    Type: Grant
    Filed: August 28, 1995
    Date of Patent: November 2, 1999
    Inventors: Michael E. Jolley, Klaus H. Nielsen