Patents by Inventor Klaus-Otto Minck

Klaus-Otto Minck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazopyridines
    Patent number: 6037349
    Abstract: Imidazopyridine derivatives ad pharmacologically acceptable salts having antagonistic properties towards angiotensin II can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.
    Type: Grant
    Filed: January 4, 1999
    Date of Patent: March 14, 2000
    Assignee: Merck Patent GmbH
    Inventors: Werner Mederski, Johannes Sombroek, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
  • Heterocyclyl-condensed benzoylguanidines, their production and use as inhibitors of the cellular Na+/H+-antiporter
    Patent number: 6028069
    Abstract: Cyclic sulphones of formula (I) are disclosed, in which: R.sup.1 and R.sup.2 each independently of one another stand for H, A, CF.sub.3, CH.sub.2 F, CHF.sub.2, C.sub.2 F.sub.5, Hal, OH, OA, NH.sub.2, NHA, NA.sub.2, NO.sub.2 or CN; X stands for CR.sup.4 R.sup.5, C.dbd.Z, O, S, NH, NA or NR.sup.3 ; Y stands for CR.sup.6 R.sup.7, C.dbd.Z, O, NH, NA, or NR.sup.3 ; Z stands for O, S, NH, NA, NOH, NOA, CH.sub.2, CHA or CA.sub.2 ; R.sup.4, R.sup.5, R.sup.6 and R.sup.7 each independently of one another stand for H, A, R.sup.3, Hal, OH, OA, SH, SA, NH.sub.2, NHA or NA.sub.2, or alternatively, R.sup.5 and R.sup.6 or R.sup.7 and R.sup.8 can together represent a bond, only one such bond being present in each molecule; R.sup.4 and R.sup.5 together can also stand for O--(CH.sub.2).sub.2 --O or O--(CH.sub.2).sub.3 --O; R.sup.8 and R.sup.9 each independently of one another stand for H or A; A stands for alkyl with 1-6 C atoms; Hal stands for F, Cl, Br or I; and R.sup.
    Type: Grant
    Filed: March 30, 1999
    Date of Patent: February 22, 2000
    Assignee: Merck Patent Gesellschaft mit berschranker Haftung
    Inventors: Manfred Baumgarth, Rolf Gericke, Klaus-Otto Minck, Norbert Beier
  • Heterocyclyloxybenzoylguanidines
    Patent number: 6022883
    Abstract: Heterocyclyloxybenzoylguanidines of the formula I ##STR1## in which R.sup.1, R.sup.2 and Het have the given meanings, and also the pharmaceutically acceptable salts thereof, exhibit antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: June 20, 1995
    Date of Patent: February 8, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Rolf Gericke, Dieter Dorsch, Manfred Baumgarth, Klaus Otto Minck, Norbert Beier
  • Ortho-substituted benzoil acid derivatives
    Patent number: 5849796
    Abstract: Ortho-substituted benzoic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 have the given meanings, and Q is guanidyl, and also their physiologically harmless salts, exhibit antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter. In addition, the compounds of the formula I, in which R.sup.1 to R.sup.3 and also Q have the given meanings, are suitable for use as valuable intermediates for the preparation of medicaments, in particular of inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: August 28, 1995
    Date of Patent: December 15, 1998
    Assignee: Merck Patent Gelsellschaft mit Beschrankter Haftung
    Inventors: Rolf Gericke, Dieter Dorsch, Manfred Baumgarth, Klaus-Otto Minck, Norbert Beier
  • Alkylbenzoylguanidine derivatives
    Patent number: 5840761
    Abstract: Alkylbenzoylguanidines of the formula I ##STR1## in which A, R.sup.1, R.sup.2 and R.sup.3 have the given meanings, and their physiologically harmless salts exhibit antiarrhythmic properties and act as inhibitor of the cellular Na.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: August 30, 1995
    Date of Patent: November 24, 1998
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Rolf Gericke, Dieter Dorsch, Manfred Baumgarth, Klaus-Otto Minck, Norbert Beier
  • Arylbenzoylguanidines
    Patent number: 5807896
    Abstract: Arylbenzoylguanidines of the formula I ##STR1## in which R.sup.1 R.sup.2, R.sup.3 and Ph have the given meanings herein, and also the physiologically harmless salts thereof, exhibit antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: August 25, 1995
    Date of Patent: September 15, 1998
    Assignee: Merck Patent Gesellschaft mit Beschrankter Hafting
    Inventors: Rolf Gericke, Dieter Dorsch, Manfred Baumgarth, Klaus-Otto Minck, Norbert Beier
  • Imidazopyridines
    Patent number: 5798364
    Abstract: Imidazopyridine derivatives and pharmacologically acceptable salts having antagonistic properties towards angiotensin II can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.
    Type: Grant
    Filed: October 4, 1996
    Date of Patent: August 25, 1998
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Werner Mederski, Johannes Sombroek, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
  • Heterocyclyl-benzoylguanidines
    Patent number: 5753680
    Abstract: Heterocyclyl-benzoylguanidines of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and Het have the meanings given herein, and physiologically unobjectionable salts thereof, display antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: August 30, 1995
    Date of Patent: May 19, 1998
    Assignee: Merck Patent Gesellschaft MIT Beschrankter Haftung
    Inventors: Rolf Gericke, Dieter Dorsch, Manfred Baumgarth, Klaus-Otto Minck, Norbert Beier
  • Fluorine-containing benzoylguanidines
    Patent number: 5747539
    Abstract: Fluorine-containing benzoylguanidines of the formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 have the meanings indicated, and their physiologically acceptable salts, have antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter, for example.
    Type: Grant
    Filed: May 15, 1996
    Date of Patent: May 5, 1998
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Dieter Dorsch, Manfred Baumgarth, Rolf Gericke, Klaus-Otto Minck, Norbert Beier
  • Sulfonyl- or sulfinylbenzoylguanidine derivatives
    Patent number: 5744641
    Abstract: 4-Sulfonyl- or 4-sulfinylbenzoylguanidines of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.6 and n have the meanings indicated, and their physiologically acceptable salts exhibit antiarrhythmic properties and, act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: April 28, 1998
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Rolf Gericke, Manfred Baumgarth, Klaus-Otto Minck, Norbert Beier
  • 4-aminobenzoylguanidine derivatives
    Patent number: 5739142
    Abstract: 4-Aminobenzoylguanidines of the formula I ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.3 have the meanings given, and the physiologically unobjectionable salts thereof exhibit antiarrhythmic properties and are active as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: January 26, 1996
    Date of Patent: April 14, 1998
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Rolf Gericke, Manfred Haumgarth, Norbert Beier, Klaus-Otto Minck
  • Alkenyl-benzoylguanidine derivatives
    Patent number: 5731351
    Abstract: Alkyl-benzoylguanidines of the formula I ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 have the meanings given, and physiologically acceptable salts thereof show antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: March 24, 1998
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Rolf Gericke, Manfred Baumgarth, Klaus-Otto Minck, Norbert Beier
  • 3-alkoxycarbonyl-thiadiazinones
    Patent number: 5705497
    Abstract: 3-Alkoxycarbonyl thiadiazinones of the formula I ##STR1## and physiologically unobjectionable salts thereof, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Q and n have the meanings described herein, exhibit a positively inotropic action and can be employed for the therapy of cardiac insufficiency.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: January 6, 1998
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Rochus Jonas, Inge Lues, Norbert Beier, Klaus-Otto Minck
  • Alkyl-5-methylsulfonylbenzoylguanidine derivatives
    Patent number: 5700839
    Abstract: Benzoylguanidines of the formula I ##STR1## wherein R.sup.1 and R.sup.2 have the meanings indicated herein, and their physiologically acceptable salts, show anti-arrhythmic properties and act as inhibitors of the cellular NA.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: October 20, 1995
    Date of Patent: December 23, 1997
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Rolf Gericke, Dieter Dorsch, Manfred Baumgarth, Klaus-Otto Minck, Norbert Beier
  • 4-mercaptobenzoylguanidine derivatives
    Patent number: 5696167
    Abstract: 4-Mercaptobenzoylguanidines of the formula I ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.3 have the meanings given, and the physiologically unobjectionable salts thereof exhibit antiarrhythmic properties and are active as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: January 30, 1996
    Date of Patent: December 9, 1997
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Rolf Gericke, Manfred Baumgarth, Klaus-Otto Minck, Norbert Beier
  • Imidazopyridines as pharmaceutical agents
    Patent number: 5684015
    Abstract: Described herein are novel imidazopyridine derivatives of the formula I ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in Patent Claim 1, and their salts, which exhibit antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: September 14, 1995
    Date of Patent: November 4, 1997
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Werner Mederski, Matthias Osswald, Pierre Schelling, Klaus-Otto Minck, Dieter Dorsch, Norbert Beier, Ingeborg Lues
  • Imidazopyridines
    Patent number: 5532276
    Abstract: Novel imidazopyridine derivatives of the formula ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, Ar.sup.1, X and Y are as defined in the specification, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: July 2, 1996
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Werner Mederski, Dieter Dorsch, Mathias Osswald, Norbert Beier, Pierre Schelling, Klaus-Otto Minck, Ingeborg Lues
  • Piperidines and piperazines
    Patent number: 5495022
    Abstract: Piperidine and piperazine derivatives of formula I ##STR1## wherein R.sup.1 and R.sup.2 are H or A,R.sup.3, R.sup.4 and R.sup.5 are each independently H, Hal, OH, OA, OAc, NO.sub.2, NH.sub.2, NHAc, NHSO.sub.2 A or CN, orR.sup.3 and R.sup.4 together are --O--(CH.sub.2).sub.m --O--,n is 0, 1 or 2X is O or CH.sub.2, if n=0 or 2, or CH.sub.2, NH, NA or NAc, if n=1,Y is CH or N,m is 1 or 2,Hal is F, Cl, Br or I,A is C.sub.1-6 -alkyl,Ac is C.sub.1-8 -alkanoyl C.sub.1-10 -aralkanoyl or C.sub.7-11 -aroyl,and their physiologically acceptable salts show antiarrhythmic effects.
    Type: Grant
    Filed: June 24, 1994
    Date of Patent: February 27, 1996
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Manfred Baumgarth, Inge Lues, Klaus-Otto Minck, Norbert Beier
  • Imidazopyridines
    Patent number: 5476857
    Abstract: Novel imidazopyridine derivatives of formula I: ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: December 19, 1995
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck, Mathias Osswald
  • 4-amino-1-piperidylbenzoylguanidines
    Patent number: 5461066
    Abstract: 4-amino-1-piperidylbenzoylguanidines of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the given meanings, and also the physiologically compatible salts thereof, exhibit antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: February 9, 1995
    Date of Patent: October 24, 1995
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Rolf Gericke, Manfred Baumgarth, Dieter Dorsch, Norbert Beier, Klaus-Otto Minck, Ingeborg Lues