Patents by Inventor Klaus Schlossmann
Klaus Schlossmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5026714Abstract: Novel blood sugar-lowering dihydropyridinelactones of the formula ##STR1## in which R represents halogen, C.sub.1 -C.sub.10 -alkyl, C.sub.1 -C.sub.10 -alkoxy, C.sub.1 -C.sub.10 -alkylthio, C.sub.1 -C.sub.10 -alkylsulphinyl, C.sub.1 -C.sub.10 -alkylsulphonyl, cyano, C.sub.1 -C.sub.6 - mono- or polyfluoroalkyl, C.sub.1 -C.sub.6 -mono- or polyfluoroalkoxy or nitro,R.sup.1 represents hydrogen, halogen or C.sub.1 -C.sub.10 -alkyl or C.sub.1 -C.sub.10 -alkoxy,R.sup.2 represents a C.sub.1 -C.sub.20 hydrocarbon radical which can optionally be interrupted or substituted,R.sup.3 represents hydrogen NH.sub.2, CHO, CN or a C.sub.1 -C.sub.6 hydrocarbon radical which can be interrupted in the chain, andR.sup.4 represents a C.sub.1 -C.sub.10 -alkyl or C.sub.2 -C.sub.10 -alkenyl radical which can optionally be interrupted or substituted with the proviso that R is not CF.sub.3 if R.sup.2 represents C.sub.2 H.sub.5.Type: GrantFiled: November 13, 1989Date of Patent: June 25, 1991Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Friedrich Bossert, Hilmar Bischoff, Dieter Petzinna, Walter Puls, Klaus Schlossmann
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Patent number: 4976964Abstract: In the parenteral administration of a dihydropyridine, the improvement which comprises administering the dihydropyridine in an aqueous medium of pH 3 to 8.5 having dispersed therein liposomes with an average diameter of 20-1000 nm, the liposome membrane containng the following constituents by weight:(a) a part of a dihydropyridine, and(b) 5-500 parts of lipids.The aqueous medium is storage stable and readily injectable.Type: GrantFiled: April 16, 1986Date of Patent: December 11, 1990Assignee: Bayer AktiengesellschaftInventors: Klaus Schlossmann, Alfred Zembrod, Stanislav Kazda, Peter Serno, Bernd Klinksiek
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Patent number: 4894378Abstract: Blood sugar levels are reduced by administration of novel 4-thienyl-dihydropyridines of the formula ##STR1## in which R.sup.1 represents 1 or 2 halogen atoms, or represents straight-chain, branched or cyclic alkyl with up to 8 carbon atoms,R.sup.2 represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical which has up to 15 carbon atoms, is optionally interrupted by one or two oxygen atoms, -N-phenyl or --SO.sub.n -- (n=0, 1 or 2) and is optionally substituted by halogen, phenyl, hydroxyl, cyano, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, pyridyl, piperidino, N-phenylpiperazino, N-methylpiperazino, morpholino or N-benzyl-N-methyl-amino,R.sup.3 represents hydrogen, or represents straight-chain, branched or cyclic alkyl which has up to 6 carbon atoms and is optionally substituted by halogen, hydroxyl, amino or amino-C.sub.1 -C.sub.6 -alkoxy, or represents cyano or formyl andR.sup.Type: GrantFiled: June 22, 1988Date of Patent: January 16, 1990Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Hilmar Bischoff, Walter Puls, Joachim Bender, Dieter Petzinna, Klaus Schlossmann
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Patent number: 4801715Abstract: Blood sugar levels are reduced by administration of novel 4-thienyl-dihydropyridines of the formula ##STR1## in which R.sup.1 represents 1 or 2 halogen atoms, or represents straight-chain, branched or cyclic alkyl with up to 8 carbon atoms,R.sup.2 represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical which has up to 15 carbon atoms, is optionally interrupted by one or two oxygen atoms, -N-phenyl or --SO.sub.n --(n=0, 1 or 2) and is optionally substituted by halogen, phenyl, hydroxyl, cyano, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, pyridyl, piperidino, N-phenylpiperazino, N-methylpiperazino, morpholino or N-benzyl-N-benzyl-N-methyl-amino,R.sup.3 represents hydrogen, or represents straight-chain, branched or cyclic alkyl which has up to 6 carbon atoms and is optionally substituted by halogen, hydroxyl, amino or amino-C.sub.1 -C.sub.6 -alkoxy, or represents cyano or formyl andR.sup.Type: GrantFiled: December 4, 1986Date of Patent: January 31, 1989Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Hilmar Bischoff, Walter Puls, Joachim Bender, Dieter Petzinna, Klaus Schlossmann
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Patent number: 4786641Abstract: Blood-sugar-lowering dihydropyridines of the formula ##STR1## in which R.sup.1 represents phenyl, naphthyl, thienyl, pyridyl, chromenyl or thiochromenyl, it being possible for the radicals mentioned each to carry up to 2 identical or different substituents from the series comprising halogen, alkyl, alkoxy and alkylthio with in each case up to 6 carbon atoms, fluoroalkyl and fluoroalkoxy with in each case up to 3 carbon atoms and 3 fluorine atoms, nitro and cyano,R.sup.2 represents straight-chain, branched or cyclic alkyl which has up to 8 carbon atoms, can be interrupted in the alkyl chain by an oxygen or a sulphur atom and can be substituted by halogen, phenyl, cyano, hydroxyl, amino, alkylamino or dialkylamino with in each case up to 3 carbon atoms per alkyl group or by N-benzylmethylamino,R.sup.Type: GrantFiled: August 20, 1987Date of Patent: November 22, 1988Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Hans-Jurgen Ahr, Walter Puls, Hilmar Bischoff, Dieter Petzinna, Klaus Schlossmann, Joachim Bender
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Patent number: 4721719Abstract: Reducing blood sugar with the novel dihydropyridinelactols, or salts thereof, of the formula ##STR1## in which R.sup.1 represents a phenyl, naphthyl, thienyl, pyridyl, chromonyl, thiochromonyl or thiochromenyl radical, the stated radicals optionally containing 1 or 2 identical or different substituents from the group consisting of fluorine, chlorine and bromine, alkyl, alkoxy and alkylthio, each having 1 to 6 carbon atoms, and fluoroalkyl or fluoroalkoxy, each having up to 3 carbon atoms and 3 fluorine atoms, and nitro and cyano,R.sup.2 represents a straight-chain, branched or cyclic alkyl having up to 12 carbon atoms which is optionally interrupted by 1 or 2 oxygen or sulphur atoms and which is optionally substituted by fluorine, chlorine, phenyl, cyano, hydroxyl, amino, C.sub.1 -C.sub.3 -alkylamino, di-C.sub.1 -C.sub.3 -alkylamino or N-benzylmethylamino,R.sup.3 represents cyano or straight-chain or branched alkyl which has up to 4 carbon atoms and is optionally interrupted in the chain by N-C.sub.1 -C.sub.Type: GrantFiled: August 27, 1986Date of Patent: January 26, 1988Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Friedrich Bossert, Hans J. Ahr, Hilmar Bischoff, Walter Puls, Dieter Petzinna, Klaus Schlossmann, Joachim Bender
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Patent number: 4670460Abstract: A method of inhibiting lipoxygenase in a patient, for the prophylaxis and/or treatment of ischaemias and disorders in cardiac rhythm, inflammations of the skin and the eye, and of rheumatic, allergic and asthmatic diseases, oedemas, pulmonary embolisms, pulmonary hypertension, shock lung, oxygen intoxications and ulcerations which comprises administering to such patient an effective amount of a compound of the formula ##STR1## wherein R represents an aryl or heteroaryl radical which has 6 to 12 C atoms and optionally contains 1 to 3 identical or different substituents from the group comprising halogen, trifluoromethyl, alkyl, alkenyl, alkoxy, alkylamino, cyano, trifluoromethoxy, nitro, hydroxyl, SO.sub.n -alkyl (n=0 to 2) or SO.sub.n -trifluoromethyl (n=0 to 2), alkyl, alkenyl and alkoxy in each case being understood as meaning radicals with 1 to 4 C atoms,R.sup.Type: GrantFiled: December 13, 1985Date of Patent: June 2, 1987Assignee: Bayer AktiengesellschaftInventors: Mithat Mardin, Friedel Seuter, Elisabeth Perzborn, Klaus Schlossmann, Dieter Mayer, Volker Fiedler
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Patent number: 4657924Abstract: A method of inhibiting lipoxygenase in a patient, for the prophylaxis and/or treatment of ischaemias and disorders in cardiac rhythm and of rheumatic, allergic and asthmatic diseases, oedemas, pulmonary embolisms, pulmonary hypertension, oxygen intoxications and ulcerations which comprises administering to such patient an effective amount of nafazatrom.Type: GrantFiled: March 25, 1985Date of Patent: April 14, 1987Assignee: Bayer AktiengesellschaftInventors: Mithat Mardin, Wolf-Dieter Busse, Friedrich Hoffmeister, Friedel Seuter, Elisabeth Perzborn, Klaus Schlossmann, Dieter Mayer, Volker Fiedler
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Patent number: 4540707Abstract: A method of inhibiting lipoxygenase in a patient, for the prophylaxis and/or treatment of ischaemias and disorders in cardiac rhythm and of rheumatic, allergic and asthmatic diseases, oedemas, pulmonary embolisms, pulmonary hypertension, oxygen intoxications and ulcerations which comprises administering to such patient an effective amount of nafazatrom.Type: GrantFiled: April 18, 1983Date of Patent: September 10, 1985Assignee: Bayer AktiengesellschaftInventors: Mithat Mardin, Wolf-Dieter Busse, Friedrich Hoffmeister, Friedel Seuter, Elisabeth Perzborn, Klaus Schlossmann, Dieter Mayer, Volker Fiedler
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Patent number: 4188395Abstract: The present invention provides 1,4-dihydropyridine derivatives of the formula in which ##STR1## R represents hydrogen, alkyl, alkenyl, alkoxyalkyl, aryl or aralkyl, the alkyl and aryl groups being optionally substituted,A represents a straight-chain or branched alkylene radical,R.sup.1 represents (a) an optionally substituted alkylthio group or (b) a group of the formula O--CO-alkyl, O--CO-aryl or O--CO-aralkyl, the alkyl and aryl groups being optionally substituted or (c) a phthalimido radical which is optionally substituted in the benzene ring, Y and Z are identical or different and each represents a group of the formula COOR.sup.2 or COR.sup.2,whereinR.sup.2 represents alkyl, alkenyl, alkinyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl or aralkyl, the alkyl and aryl radicals being optionally substituted, orY and Z are identical or different and each represents a cyano radical or a radical of the formula S(O).sub.n --R.sup.3,whereinR.sup.Type: GrantFiled: December 1, 1977Date of Patent: February 12, 1980Assignee: Bayer AktiengesellschaftInventors: Friedrich Bossert, Egbert Wehinger, Horst Meyer, Arend Heise, Stanislav Kazda, Kurt Stoepel, Robertson Towart, Wulf Vater, Klaus Schlossmann
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Patent number: 4177278Abstract: The invention includes the provision of 2-alkyleneaminodihydropyridines and salts thereof and are useful, inter alia, as coronary dilators and antihypertensive agents. Also included in the invention are pharmaceutical compositions containing said 2-alkyleneaminodihydropyridines and methods of treatment involving the use of said compounds or compositions.Type: GrantFiled: March 15, 1978Date of Patent: December 4, 1979Assignee: Bayer AktiengesellschaftInventors: Friedrich Bossert, Egbert Wehinger, Arend Heise, Stanislav Kazda, Kurt Stoepel, Robertson Towart, Wulf Vater, Klaus Schlossmann