Patents by Inventor Koen Jan Ludovicus Augustyns

Koen Jan Ludovicus Augustyns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzo-diazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives
    Patent number: 9975899
    Abstract: The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives of Formula (I) wherein R1, R2, R3, R4 and Het have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: May 22, 2018
    Assignee: Janssen Pharmaceutica NV
    Inventors: Lieven Meerpoel, Louis Jules Roger Marie Maes, Kelly de Wit, Koen Jan Ludovicus Augustyns
  • NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES
    Publication number: 20170073348
    Abstract: The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives of Formula (I) wherein R1, R2, R3, R4 and Het have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
    Type: Application
    Filed: November 3, 2016
    Publication date: March 16, 2017
    Inventors: Lieven Meerpoel, Louis Jules Roger Marie MAES, Kelly de Wit, Koen Jan Ludovicus AUGUSTYNS
  • Antifungal 5,6-dihydro-4-pyrrolo[1,2-][1,4]benzo-diazepines and 6-pyrrolo[1,2-][1,4]benzodiazepines substituted with heterocyclic derivatives
    Patent number: 9493468
    Abstract: The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives of Formula (I) wherein R1, R2, R3, R4 and Het have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
    Type: Grant
    Filed: May 3, 2012
    Date of Patent: November 15, 2016
    Assignee: Janssen Pharmaceutica NV
    Inventors: Lieven Meerpoel, Louis Jules Roger Marie Maes, Kelly de Wit, Koen Jan Ludovicus Augustyns
  • NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES
    Publication number: 20140045827
    Abstract: The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives of Formula (I) wherein R1, R2, R3, R4 and Het have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
    Type: Application
    Filed: May 3, 2012
    Publication date: February 13, 2014
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventors: Lieven Meerpoel, Louis Jules Roger Marie Maes, Kelly de Wit, Koen Jan Ludovicus Augustyns
  • Serine peptidase modulators
    Publication number: 20020061839
    Abstract: The present invention relates to new compounds having modulatory (inhibitory and stimulatory) activity on serine peptidases and proteases in general and dipeptidyl peptidase IV, prolyl oligopeptidase (PO), dipeptidyl peptidase II (DPP II), fibroblast activation protein &agr; (FAP&agr;), lysosomal Pro—X carboxypeptidase and elastase in particular. These new compounds can be used for the treatment of a variety of disease states in which these peptidases are involved.
    Type: Application
    Filed: April 18, 2001
    Publication date: May 23, 2002
    Inventors: Simon Lodewijk Scharpe, Ingrid Anna Jozef De Meester, Anne-Marie Virginie Renee Lambeir, Koen Jan Ludovicus Augustyns, Achiel Jean-Marie Haemers, Filip Jozef Anny Goossens, Dirk Frans Hendriks, Alexandre Arkadicvitch Beliaev
  • Serine proteases, their activity and their synthetic inhibitors
    Patent number: 6090786
    Abstract: The present invention relates to new compounds of the general formula: Z-Xaa-Y', in which Xaa is an amino acid, Z is a protecting group and Y' is one of various types of ring structures. The new compounds have a modulating activity on serine proteases. The invention further relates to the use of the compounds in therapy and diagnosis and to a method of purifying the serine protease DPPIV.
    Type: Grant
    Filed: February 19, 1997
    Date of Patent: July 18, 2000
    Assignee: FondaTech Benelux N.V.
    Inventors: Koen Jan Ludovicus Augustyns, Greta Constantia Vanhoof, Marianne Jean Frieda Borloo, Ingrid Anna Jozef De Meester, Filip Jozef Anny Goossens, Achiel Jean-Marie Haemers, Dirk Frans Hendriks, Anne-Marie Virginie Renee Lambeir, Simon Lodewijk Scharpe