Patents by Inventor Kogyoku Shin
Kogyoku Shin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9738656Abstract: Compounds represented by formulae (I) to (XXII) or pharmaceutically acceptable salts thereof:Type: GrantFiled: November 9, 2016Date of Patent: August 22, 2017Assignee: Eisai R&D Management Co., Ltd.Inventors: Toshiki Kurokawa, Yu Yoshida, Kogyoku Shin, Yoshihisa Kobayashi, Hironori Fukumoto, Kunitoshi Takeda, Yoshiaki Ohashi, Makoto Kotake, Tomoyuki Shibuguchi, Toru Watanabe, Yoichi Kita, Shinsuke Hirota, Takashi Fukuyama, Yasuaki Kamada
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Publication number: 20170137436Abstract: Compounds represented by formulae (I) to (XXII) or pharmaceutically acceptable salts thereof:Type: ApplicationFiled: November 9, 2016Publication date: May 18, 2017Inventors: Toshiki Kurokawa, Yu Yoshida, Kogyoku Shin, Yoshihisa Kobayashi, Hironori Fukumoto, Kunitoshi Takeda, Yoshiaki Ohashi, Makoto Kotake, Tomoyuki Shibuguchi, Toru Watanabe, Yoichi Kita, Shinsuke Hirota, Takashi Fukuyama, Yasuaki Kamada
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Patent number: 8530504Abstract: A compound represented by the formula (I) or pharmacologically acceptable salt thereof exhibits an excellent CRF receptor antagonism wherein X is a nitrogen atom or CH; R1 is -A11-A12; A11 is a single bond or a C1-6 alkylene group; A12 is a hydrogen atom, a C1-6 alkyl group or a C3-6 cycloalkyl group, etc.; R2 is -A21-A22; A21 is a single bond or a C1-6 alkylene group; A22 is a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a non-aromatic heterocyclic group, or a heteroaryl group, etc.; R3 is a C1-6 alkyl group, a C3-6 cycloalkyl group, a C1-6 alkoxy group, a C3-6 cycloalkoxy C1-6 alkyl group, di-C1-6 alkyl amino group, a halogen atom, a cyano group, a formyl group, or a carboxyl group, etc; R4 is a hydrogen atom or a C1-6 alkoxy group; R5 is a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R6 is a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkylthio group, or a C1-6 alkyl sulfinyl group etc.Type: GrantFiled: October 7, 2010Date of Patent: September 10, 2013Assignee: Eisai R&D Management Co., Ltd.Inventors: Kogyoku Shin, Taro Terauchi, Yoshinori Takahashi, Minako Hashizume, Kunitoshi Takeda, Kodo Shikata, Akira Inomata
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Patent number: 8431603Abstract: A compound represented by the following formula (I), or salt thereof exhibits excellent CRF receptor antagonism, and sufficient pharmacological activity, safety and pharmacokinetic properties as a drug. wherein R1 represents the formula -A11-A12; R2 represents tetrahydrofurylmethyl, tetrahydropyranylmethyl or tetrahydropyranyl; A11 represents a single bond, methylene or 1,2-ethylene; A12 represents C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl having methyl; R3 represents methoxy, cyano, cyclobutyloxymethyl, methoxymethyl or ethoxymethyl; and R4 represents methoxy or chlorine.Type: GrantFiled: April 9, 2009Date of Patent: April 30, 2013Assignee: Eisai R&D Management Co., Ltd.Inventors: Hisashi Shibata, Kodo Shikata, Akira Inomata, Kogyoku Shin, Taro Terauchi, Yoshinori Takahashi, Minako Hashizume, Kunitoshi Takeda
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Publication number: 20110086898Abstract: A compound represented by the formula (I) or pharmacologically acceptable salt thereof exhibits an excellent CRF receptor antagonism.Type: ApplicationFiled: October 7, 2010Publication date: April 14, 2011Applicant: Eisai R&D Management Co., Ltd.Inventors: Kogyoku SHIN, Taro Terauchi, Yoshinori Takahashi, Minako Hashizume, Kunitoshi Takeda, Kodo Shikata, Akira Inomata
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Publication number: 20110086860Abstract: A compound represented by Formula (I) is provided: wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) —C?C— or (2) a double bond etc., which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group which may be substituted, or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents.Type: ApplicationFiled: December 21, 2010Publication date: April 14, 2011Inventors: Teiji KIMURA, Koki Kawano, Eriko Doi, Noritaka Kitazawa, Kogyoku Shin, Takehiko Miyagawa, Toshihiko Kaneko, Koichi Ito, Mamoru Takaishi, Takeo Sasaki, Hiroaki Hagiwara
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Publication number: 20110086882Abstract: A compound represented by the formula (I) or pharmacologically acceptable salt thereof exhibits an excellent CRF receptor antagonism wherein X is a nitrogen atom or CH; R1 is -A11-A12; A11 is a single bond or a C1-6 alkylene group; A12 is a hydrogen atom, a C1-6 alkyl group or a C3-6 cycloalkyl group, etc.; R2 is -A21-A22; A21 is a single bond or a C1-6 alkylene group; A22 is a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a non-aromatic heterocyclic group, or a heteroaryl group, etc.; R3 is a C1-6 alkyl group, a C3-6 cycloalkyl group, a C1-6 alkoxy group, a C3-6 cycloalkoxy C1-6 alkyl group, di-C1-6 alkyl amino group, a halogen atom, a cyano group, a formyl group, or a carboxyl group, etc; R4 is a hydrogen atom or a C1-6 alkoxy group; R5 is a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R6 is a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkylthio group, or a C1-6 alkyl sulfinyl group etc.Type: ApplicationFiled: October 7, 2010Publication date: April 14, 2011Applicant: Eisai R&D Management Co., Ltd.Inventors: Kogyoku SHIN, Taro TERAUCHI, Yoshinori TAKAHASHI, Minako HASHIZUME, Kunitoshi TAKEDA, Kodo SHIKATA, Akira INOMATA
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Patent number: 7880009Abstract: The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) —C?C— or (2) a double bond etc. which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted) or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents.Type: GrantFiled: May 25, 2005Date of Patent: February 1, 2011Assignee: Eisai R&D Management Co., Ltd.Inventors: Teiji Kimura, Koki Kawano, Eriko Doi, Noritaka Kitazawa, Kogyoku Shin, Takehiko Miyagawa, Toshihiko Kaneko, Koichi Ito, Mamoru Takaishi, Takeo Sasaki, Hiroaki Hagiwara
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Patent number: 7772249Abstract: The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein R1 denotes a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group and the like; R2 denotes a halogen atom, a cyano group, a nitro group, a C1-10 alkyl group, a C2-10 alkenyl group, C2-10 alkynyl group and the like; R3 denotes a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR4 (wherein R4 denotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated C1-6 alkyl group and the like) and, in this case, at least two of X, Y and Z denote CR4.Type: GrantFiled: March 3, 2009Date of Patent: August 10, 2010Assignee: Eisai R&D Management Co., Ltd.Inventors: Shigeki Hibi, Yoshinori Takahashi, Yorihisa Hoshino, Koichi Kikuchi, Motohiro Soejima, Tatsuya Yoshiuchi, Kogyoku Shin, Mutsuko Ono, Hisashi Shibata, Mitsuhiro Ino, Tetsuya Hirakawa
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Publication number: 20100105904Abstract: Disclosed is a compound represented by the formula (I) below or a pharmacologically acceptable salt thereof. Also disclosed is a use of the compound or salt as a pharmaceutical product. (In the formula, Ar1 represents an imidazolyl group which may be substituted with a C1-6 alkyl group; Ar2 represents a phenyl group which may be substituted with a C1-6 alkoxy group; X1 represents a single bond; R1 and R2 respectively represent a C1-6 alkyl group or the like which may be substituted with a substituent such as a 5- to 14-membered aromatic heterocyclic group; and R3 represents a hydrogen atom or the like.Type: ApplicationFiled: May 18, 2007Publication date: April 29, 2010Inventors: Teiji Kimura, Koki Kawano, Eriko Doi, Noritaka Kitazawa, Takehiko Miyagawa, Nobuaki Sato, Toshihiko Kaneko, Kogyoku Shin, Koichi Ito, Mamoru Takaishi, Takeo Sasaki, Hiroaki Hagiwara
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Patent number: 7687640Abstract: The present invention relates to a process for preparing a compound of formula (6a): wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents shown below; Ar2 represents a pyridinyl group, a pyrimidinyl group or a phenyl group which may be substituted with 1 to 3 substituents; and R11 represents a group selected from certain substituents.Type: GrantFiled: July 2, 2009Date of Patent: March 30, 2010Assignee: Eisai R&D Management Co., Ltd.Inventors: Teiji Kimura, Koki Kawano, Eriko Doi, Noritaka Kitazawa, Kogyoku Shin, Takehiko Miyagawa, Toshihiko Kaneko, Koichi Ito, Mamoru Takaishi, Takeo Sasaki, Hiroaki Hagiwara
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Patent number: 7667041Abstract: The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) —C?C— or (2) a double bond etc. which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted) or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents. The object of the present invention is to find a therapeutic or preventive agent for diseases caused by A?. According to the present invention, a therapeutic or preventive agents for diseases caused by A? can be provided.Type: GrantFiled: May 25, 2005Date of Patent: February 23, 2010Assignee: Eisai R&D Management Co., Ltd.Inventors: Teiji Kimura, Koki Kawano, Eriko Doi, Noritaka Kitazawa, Kogyoku Shin, Takehiko Miyagawa, Toshihiko Kaneko, Koichi Ito, Mamoru Takaishi, Hiroaki Hagiwara
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Patent number: 7625925Abstract: Compounds represented by the general formula: [wherein R1 represents methoxy, ethyl, methylthio, etc., R2, R3 and R4 each represent hydrogen, a halogen, etc., R5 and R6 each represent —X5—X6—X7 (wherein X5 represents a single bond or —CO—, X6 represents a single bond, —NR3a, etc. and X7 and R3a each represent hydrogen, C1-10 alkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.Type: GrantFiled: June 4, 2007Date of Patent: December 1, 2009Assignee: Eisai R&D Management Co., LtdInventors: Shigeki Hibi, Koichi Kikuchi, Yorihisa Hoshino, Motohiro Soejima, Tatsuya Yoshiuchi, Kogyoku Shin, Mutsuko Ono, Yoshinori Takahashi, Hisashi Shibata, Mitsuhiro Ino, Tetsuya Hirakawa
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Publication number: 20090281310Abstract: The present invention relates to a process for preparing a compound of formula (6a): wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents shown below; Ar2 represents a pyridinyl group, a pyrimidinyl group or a phenyl group which may be substituted with 1 to 3 substituents; and R11 represents a group selected from certain substituents.Type: ApplicationFiled: July 2, 2009Publication date: November 12, 2009Inventors: Teiji KIMURA, Koki KAWANO, Eriko DOI, Noritaka KITAZAWA, Kogyoku SHIN, Takehiko MIYAGAWA, Toshihiko KANEKO, Koichi ITO, Mamoru TAKAISHI, Takeo SASAKI, Hiroaki HAGIWARA
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Publication number: 20090259049Abstract: A compound represented by the following formula (I), or salt thereof exhibits excellent CRF receptor antagonism, and sufficient pharmacological activity, safety and pharmacokinetic properties as a drug. wherein R1 represents the formula -A11-A12; R2 represents tetrahydrofurylmethyl, tetrahydropyranylmethyl or tetrahydropyranyl; A11 represents a single bond, methylene or 1,2-ethylene; A12 represents C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl having methyl; R3 represents methoxy, cyano, cyclobutyloxymethyl, methoxymethyl or ethoxymethyl; and R4 represents methoxy or chlorine.Type: ApplicationFiled: April 9, 2009Publication date: October 15, 2009Applicant: Eisai R & D Management Co., Ltd.Inventors: Hisashi Shibata, Kodo Shikata, Akira Inomata, Kogyoku Shin, Taro Terauchi, Yoshinori Takahashi, Minako Hashizume, Kunitoshi Takeda
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Publication number: 20090203697Abstract: Disclosed is a compound represented by the formula (I) below or a pharmacologically acceptable salt thereof. Also disclosed is a use of the compound or salt as a pharmaceutical product. (In the formula, Ar1 represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like; Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group or the like; X1 represents —CR3?CR4— (wherein R3 and R4 respectively represent a C1-6 alkyl group or the like); and R1 and R2 respectively represent a C1-6 alkyl group or the like.Type: ApplicationFiled: May 18, 2007Publication date: August 13, 2009Inventors: Teiji Kimura, Koki Kawano, Eriko Doi, Noritaka Kitazawa, Takehiko Miyagawa, Nobuaki Sato, Toshihiko Kaneko, Kogyoku Shin, Koichi Ito, Mamoru Takaishi, Takeo Sasaki, Hiroaki Hagiwara
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Publication number: 20090181985Abstract: The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein R1 denotes a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group and the like; R2 denotes a halogen atom, a cyano group, a nitro group, a C1-10 alkyl group, a C2-10 alkenyl group, C2-10 alkynyl group and the like; R3 denotes a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR4 (wherein R4 denotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated C1-6 alkyl group and the like) and, in this case, at least two of X, Y and Z denote CR4.Type: ApplicationFiled: March 3, 2009Publication date: July 16, 2009Applicant: Eisai R&D Management Co., Ltd.Inventors: Shigeki Hibi, Yoshinori Takahashi, Yorihisa Hoshino, Koichi Kikuchi, Motohiro Soejima, Tatsuya Yoshiuchi, Kogyoku Shin, Matsuko Ono, Hisashi Shibata, Mitsuhiro Ino, Tetsuya Hirakawa
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Publication number: 20080076943Abstract: A compound represented by the formula: [wherein R1 is methoxy, methylthio, ethyl, etc.; R5 and R6 are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R40, R41 and R42 are C1-6 alkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor.Type: ApplicationFiled: September 20, 2007Publication date: March 27, 2008Inventors: Shigeki HIBI, Yorihisa HOSHINO, Koichi KIKUCHI, Kogyoku SHIN, Yoshinori TAKAHASHI, Masae FUJISSAWA, Hisashi SHIBATA, Mitsuhiro INO
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Publication number: 20080070902Abstract: The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) —C?C— or (2) a double bond etc. which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted) or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents.Type: ApplicationFiled: May 25, 2005Publication date: March 20, 2008Inventors: Teiji Kimura, Koki Kawano, Eriko Doi, Noritaka Kitazawa, Kogyoku Shin, Takehiko Miyagawa, Toshihiko Kaneko, Koichi Ito, Mamoru Takaishi, Takeo Sasaki, Hiroaki Hagiwara
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Patent number: 7323569Abstract: A compound represented by the formula: [wherein R1 is methoxy, methylthio, ethyl, etc.; R5 and R6 are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R40, R41 and R42 are C1-6 alkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor.Type: GrantFiled: October 22, 2003Date of Patent: January 29, 2008Assignee: Eisai R&D Management Co., Ltd.Inventors: Shigeki Hibi, Yorihisa Hoshino, Koichi Kikuchi, Kogyoku Shin, Yoshinori Takahashi, Masae Fujisawa, Hisashi Shibata, Mitsuhiro Ino