Patents by Inventor Kohichiro Yoshino

Kohichiro Yoshino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for evaluating therapeutic agent for dermatitis and/or alopecia, therapeutic agent for dermatitis and/or alopecia, and transgenic mouse
    Publication number: 20050283846
    Abstract: A method for evaluating an effect of an agent to be tested on alopecia, using a transgenic mouse to which an interleukin-18 gene under control of a keratinocyte promoter is introduced, or a method for evaluating an effect of an agent to be tested on skin, using the transgenic mouse, wherein the following (A) and/or (B) are used as an evaluation indicator. (A) spontaneous dermatitis (B) dermal inflammation at a time of a first administration of a phlogogenous material Using the transgenic mouse, the effect of an agent to be tested on dermatitis for which autoimmune dermatitis is a typical example and/or alopecia can be examined, and an agent for preventing/treating dermatitis or alopecia can be provided.
    Type: Application
    Filed: August 25, 2005
    Publication date: December 22, 2005
    Inventors: Tomoaki Hoshino, Yusuke Kawase, Keiko Nomiyama, Koichi Yokota, Kohichiro Yoshino
  • Preventive or therapeutic agents for dermatitis or alopecia, evaluation method of the agents, and transgenic mouse
    Publication number: 20040191172
    Abstract: A method for evaluating an effect of an agent to be tested on alopecia, using a transgenic mouse to which an interleukin-18 gene under control of a keratinocyte promoter is introduced, or a method for evaluating an effect of an agent to be tested on skin, using the transgenic mouse, wherein the following (A) and/or (B) are used as an evaluation indicator.
    Type: Application
    Filed: October 30, 2003
    Publication date: September 30, 2004
    Inventors: Tomoaki Hoshino, Yusuke Kawase, Keiko Nomiyama, Koichi Yokota, Kohichiro Yoshino
  • Keratinocyte growth inhibitors and hydroxamic acid derivatives
    Publication number: 20030229113
    Abstract: This invention relates to a keratinocyte-proliferation inhibitor comprising as active ingredient a compound having an activity of inhibiting the solubilization of heparin-binding EGF-like growth factor bound to cell membranes and a compound of the formula (I); 1
    Type: Application
    Filed: February 19, 2003
    Publication date: December 11, 2003
    Inventors: Koji Hashimoto, Shigeki Higashiyama, Kohichiro Yoshino, Kazuya Yoshiizumi, Minoru Yamamoto
  • Methods of reducing tumor colony number using novel benzothiazole compounds
    Patent number: 6013659
    Abstract: This invention pertains to methods of treating cancer by reducing tumor colony number in a mammalian host using benzothiazole activated natural killer cells and interleukin-2. The benzothiazoles are of the formula I: ##STR1## wherein R.sub.1 is 4-OMe and R.sub.2 is 4-tBu or 4-CF.sub.3.
    Type: Grant
    Filed: September 4, 1998
    Date of Patent: January 11, 2000
    Assignee: University of Pittsburgh
    Inventors: Ronald H. Goldfarb, Masami Ohashi, Kohichiro Yoshino
  • Quinazoline compound and anti-tumor agent containing said compound as an active ingredient
    Patent number: 5912247
    Abstract: A quinazoline compound of the formula (I): ##STR1## wherein Z means a group of the formula: ##STR2## (X is CH.sub.2, CHOH, CHOCH.sub.3, or O, and n is 1 to 3), or a group of the formula: ##STR3## (A is H or CH.sub.3, and B is --CH.sub.2 OH, or ethyl having 1 or 2 OH, or propyl having 2 or 3 OH), or a salt thereof, which are useful as anti-tumor agent, and a pharmaceutical composition containing the compound as an active ingredient.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: June 15, 1999
    Assignee: Kanebo, Ltd.
    Inventors: Yoshikazu Jinbo, Tomohiro Miyasaka, Yoshiaki Ikeda, Takashi Sekida, Kei Naruse, Masayuki Ando, Shigeru Iwaki, Kohichiro Yoshino
  • Novel cyanoguanidine derivatives
    Patent number: 5087640
    Abstract: Compounds of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently fluorine, chlorine or bromine atom, and R.sup.3 is a C.sub.4 -C.sub.7 alkyl having at least a branch at the C.sub.1 position, exhibit K.sup.+ channel opening activity and are useful as hypotensive agents and coronary vasodilators.
    Type: Grant
    Filed: June 27, 1990
    Date of Patent: February 11, 1992
    Assignee: Kanebo, Ltd.
    Inventors: Tominori Morita, Kazuya Yoshiizumi, Noriyasu Nishimura, Katsumi Goto, Takayuki Sukamoto, Kohichiro Yoshino
  • Novel benzothiazole and antirheumatic agent comprising it as an active ingredient
    Patent number: 4910211
    Abstract: A benzothiazole of the following formula ##STR1## in which R represents a methyl, methoxy, carboxyl or methoxycarbonyl group. The compound is useful for treating rheumatic arthritis.
    Type: Grant
    Filed: August 8, 1988
    Date of Patent: March 20, 1990
    Assignee: Kanebo Ltd.
    Inventors: Atsushi Imamura, Noriyuki Hori, Tadayuki Saito, Noriyasu Nishimura, Masami Ohashi, Kohichiro Yoshino