Abstract: The present invention provides preparations for efficaciously administering ginsenoside Rb1 or its salt useful as cytoprotective agents. More particularly, the present invention provides pharmaceutical compositions comprising ginsenoside Rb1 or its salt for inhibiting apoptosis or apoptosis-like cell death or pharmaceutical compositions comprising ginsenoside Rb1 or its salt for promoting the expression of a cell death-inhibitory gene product Bcl-xL. Further, the present invention provides preparations for intravenous administration comprising ginsenoside Rb1 or its salt. The above pharmaceutical compositions contain ginsenoside Rb1 or its salt at low extracellular concentrations in lesion, preferably at 1 ng/ml or less and still preferably at 1 to 100 fg/ml. These compositions promote the expression of the cell death-inhibitory gene product Bcl-xL and inhibit apoptosis or apoptosis-like cell death.

Abstract: The present invention provides preparations for efficaciously administering ginsenoside Rb1 or its salt useful as cytoprotective agents. More particularly, the present invention provides pharmaceutical compositions comprising ginsenoside Rb1 or its salt for inhibiting apoptosis or apoptosis-like cell death or pharmaceutical compositions comprising ginsenoside Rb1 or its salt for promoting the expression of a cell death-inhibitory gene product Bcl-xL. Further, the present invention provides preparations for intravenous administration comprising ginsenoside Rb1 or its salt. The above pharmaceutical compositions contain ginsenoside Rb1 or its salt at low extracellular concentrations in lesion, preferably at 1 ng/ml or less and still preferably at 1 to 100 fg/ml. These compositions promote the expression of the cell death-inhibitory gene product Bcl-xL and inhibit apoptosis or apoptosis-like cell death.

Abstract: A hydraulic transmission device operable to translate hydraulic energy into mechanical energy and vice versa. The device has a housing 14 having a close end portion and an open end portion in the longitudinal direction. The housing supports therein a drive shaft 11, a retainer 12, and a cylinder block 13 which have an integral structure. A recess is formed at a substantially central location of the end surface of the cylinder block 13 that is on the side of an open end of the housing, and a cover 15 closing the open end of the housing has a protruding portion 15A which extends through a port plate 23 to be engaged with the recess of the cylinder block through a bearing 17. A plurality of pistons are disposed in the cylinder block and are kept in tight engagement with a swash plate fixed to the closed end portion of the housing at a constant tilt angle. The device acts as either a swash plate type axial piston pump or motor of this type as the drive shaft rotates.