Patents by Inventor Koichi Shibusawa
Koichi Shibusawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11993806Abstract: The present invention provides a method of detecting and a method of quantifying oligonucleotides with more excellent specificity and quantitativity as compared to conventional signal amplification (PALSAR) measurement methods. In the present invention, the problem is solved by hybridizing a target oligonucleotide to be measured with a complementary nucleic acid probe (3?-complementary sequence of target sequence-5?), or hybridizing the target oligonucleotide to be measured having given bases such as poly(A) added thereto with a complementary nucleic acid probe (3?-complementary sequence of target oligonucleotide+complementary sequence of given bases-5?), decomposing and removing an incomplete hybridization product by using a single-strand-specific nuclease such as Si nuclease, and measuring the nucleic acid probe contained in a remaining complete hybridization product by a PALSAR method.Type: GrantFiled: September 10, 2019Date of Patent: May 28, 2024Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Akane Oomori, Koichi Shibusawa
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Publication number: 20220049284Abstract: The present invention provides a method of detecting and a method of quantifying oligonucleotides with more excellent specificity and quantitativity as compared to conventional signal amplification (PALSAR) measurement methods. In the present invention, the problem is solved by hybridizing a target oligonucleotide to be measured with a complementary nucleic acid probe (3?-complementary sequence of target sequence-5?), or hybridizing the target oligonucleotide to be measured having given bases such as poly(A) added thereto with a complementary nucleic acid probe (3?-complementary sequence of target oligonucleotide+complementary sequence of given bases-5?), decomposing and removing an incomplete hybridization product by using a single-strand-specific nuclease such as Si nuclease, and measuring the nucleic acid probe contained in a remaining complete hybridization product by a PALSAR method.Type: ApplicationFiled: September 10, 2019Publication date: February 17, 2022Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Akane OOMORI, Koichi SHIBUSAWA
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Patent number: 10564071Abstract: Provided is an examination method for a damping force variable mechanism, the examination method including: an operation step of operating a damper in a state in which the damper is installed in a vehicle, the damper being provided with a damping force variable mechanism that changes a damping force according to an input current (an example of a signal); and a detection step of detecting an induction current (an example of an output from the vehicle) from the damping force variable mechanism of the damper installed in the vehicle, wherein a detection device that performs the operation of the detection step is provided. Thus, the damping force variable mechanism of a pressure damping device can be examined in a state in which the damping force variable mechanism is installed in the vehicle.Type: GrantFiled: February 2, 2015Date of Patent: February 18, 2020Assignees: Showa Corporation, Honda Motor Co., Ltd.Inventors: Seiryo Konakai, Ken Issiki, Ryoma Kanda, Yukihiro Orimoto, Koichi Shibusawa, Tomohiro Yamazaki
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Patent number: 9758005Abstract: A suspension controller includes a wheel speed sensor that detects the wheel speed of each wheel, a basic input amount calculating unit that calculates the basic input amount of the vehicle on the basis of a wheel speed variation detected by the wheel speed sensor, a state amount calculating unit that calculates the state amount of the vehicle by inputting the basic input amount to a vehicle model representing the motion of the vehicle, and a damper controlling unit that controls the damping force of a damping-force-variable damper on the basis of the calculated state amount. If the wheel speed variation detected by the wheel speed sensor decreases below zero by a predetermined value or more on the minus side, the vertical load of the wheel is considered to be decreased, and the damping force is controlled to be greater than before the decrease.Type: GrantFiled: April 27, 2016Date of Patent: September 12, 2017Assignee: HONDA MOTOR CO., LTD.Inventors: Ryoma Kanda, Yukihiro Orimoto, Koichi Shibusawa, Tomohiro Yamazaki
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Publication number: 20170199103Abstract: Provided is an examination method for a damping force variable mechanism, the examination method including: an operation step of operating a damper in a state in which the damper is installed in a vehicle, the damper being provided with a damping force variable mechanism that changes a damping force according to an input current (an example of a signal); and a detection step of detecting an induction current (an example of an output from the vehicle) from the damping force variable mechanism of the damper installed in the vehicle, wherein a detection device that performs the operation of the detection step is provided. Thus, the damping force variable mechanism of a pressure damping device can be examined in a state in which the damping force variable mechanism is installed in the vehicle.Type: ApplicationFiled: February 2, 2015Publication date: July 13, 2017Applicants: Showa Corporation, Honda Motor Co., Ltd.Inventors: Seiryo KONAKAI, Ken ISSIKI, Ryoma KANDA, Yukihiro ORIMOTO, Koichi SHIBUSAWA, Tomohiro YAMAZAKI
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Publication number: 20160318364Abstract: A suspension controller includes a wheel speed sensor that detects the wheel speed of each wheel, a basic input amount calculating unit that calculates the basic input amount of the vehicle on the basis of a wheel speed variation detected by the wheel speed sensor, a state amount calculating unit that calculates the state amount of the vehicle by inputting the basic input amount to a vehicle model representing the motion of the vehicle, and a damper controlling unit that controls the damping force of a damping-force-variable damper on the basis of the calculated state amount. If the wheel speed variation detected by the wheel speed sensor decreases below zero by a predetermined value or more on the minus side, the vertical load of the wheel is considered to be decreased, and the damping force is controlled to be greater than before the decrease.Type: ApplicationFiled: April 27, 2016Publication date: November 3, 2016Applicant: HONDA MOTOR CO., LTD.Inventors: Ryoma Kanda, Yukihiro Orimoto, Koichi Shibusawa, Tomohiro Yamazaki
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Patent number: 8557259Abstract: It is an object of the present invention to provide a liquid preparation which excels in stability with no occurrence of precipitates and lees even after long storage. The liquid preparation contains a lipophilic material, a sucrose fatty acid ester, a polyoxyethylene hydrogenated castor oil, a polyglycerin fatty acid ester, a polyol and water. Also provided are a pharmaceutical preparation, cosmetic preparation, food and drink which contain the liquid preparation.Type: GrantFiled: April 7, 2006Date of Patent: October 15, 2013Assignee: Eisai R&D Management Co., Ltd.Inventors: Norio Goto, Koichi Shibusawa
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Publication number: 20060189662Abstract: It is an object of the present invention to provide a liquid preparation which excels in stability with no occurrence of precipitates and lees even after long storage. The liquid preparation contains a lipophilic material, a sucrose fatty acid ester, a polyoxyethylene hydrogenated castor oil, a polyglycerin fatty acid ester, a polyol and water. Also provided are a pharmaceutical preparation, cosmetic preparation, food and drink which contain the liquid preparation.Type: ApplicationFiled: April 7, 2006Publication date: August 24, 2006Inventors: Norio Goto, Koichi Shibusawa
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Patent number: 5035895Abstract: An aqueous solution comprises a fat-soluble substance, a phosphatide, a polyhydric alcohol and a basic amino acid, a salt thereof or Meglumin. It is uniformly emulsified and solubilized for the pharmaceutical use.Type: GrantFiled: January 20, 1989Date of Patent: July 30, 1991Assignee: Eisai Co., Ltd.Inventors: Koichi Shibusawa, Shigemitsu Ohsawa