Patents by Inventor Koichi Shibusawa

Koichi Shibusawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11993806
    Abstract: The present invention provides a method of detecting and a method of quantifying oligonucleotides with more excellent specificity and quantitativity as compared to conventional signal amplification (PALSAR) measurement methods. In the present invention, the problem is solved by hybridizing a target oligonucleotide to be measured with a complementary nucleic acid probe (3?-complementary sequence of target sequence-5?), or hybridizing the target oligonucleotide to be measured having given bases such as poly(A) added thereto with a complementary nucleic acid probe (3?-complementary sequence of target oligonucleotide+complementary sequence of given bases-5?), decomposing and removing an incomplete hybridization product by using a single-strand-specific nuclease such as Si nuclease, and measuring the nucleic acid probe contained in a remaining complete hybridization product by a PALSAR method.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: May 28, 2024
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventors: Akane Oomori, Koichi Shibusawa
  • Publication number: 20220049284
    Abstract: The present invention provides a method of detecting and a method of quantifying oligonucleotides with more excellent specificity and quantitativity as compared to conventional signal amplification (PALSAR) measurement methods. In the present invention, the problem is solved by hybridizing a target oligonucleotide to be measured with a complementary nucleic acid probe (3?-complementary sequence of target sequence-5?), or hybridizing the target oligonucleotide to be measured having given bases such as poly(A) added thereto with a complementary nucleic acid probe (3?-complementary sequence of target oligonucleotide+complementary sequence of given bases-5?), decomposing and removing an incomplete hybridization product by using a single-strand-specific nuclease such as Si nuclease, and measuring the nucleic acid probe contained in a remaining complete hybridization product by a PALSAR method.
    Type: Application
    Filed: September 10, 2019
    Publication date: February 17, 2022
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Akane OOMORI, Koichi SHIBUSAWA
  • Patent number: 10564071
    Abstract: Provided is an examination method for a damping force variable mechanism, the examination method including: an operation step of operating a damper in a state in which the damper is installed in a vehicle, the damper being provided with a damping force variable mechanism that changes a damping force according to an input current (an example of a signal); and a detection step of detecting an induction current (an example of an output from the vehicle) from the damping force variable mechanism of the damper installed in the vehicle, wherein a detection device that performs the operation of the detection step is provided. Thus, the damping force variable mechanism of a pressure damping device can be examined in a state in which the damping force variable mechanism is installed in the vehicle.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: February 18, 2020
    Assignees: Showa Corporation, Honda Motor Co., Ltd.
    Inventors: Seiryo Konakai, Ken Issiki, Ryoma Kanda, Yukihiro Orimoto, Koichi Shibusawa, Tomohiro Yamazaki
  • Patent number: 9758005
    Abstract: A suspension controller includes a wheel speed sensor that detects the wheel speed of each wheel, a basic input amount calculating unit that calculates the basic input amount of the vehicle on the basis of a wheel speed variation detected by the wheel speed sensor, a state amount calculating unit that calculates the state amount of the vehicle by inputting the basic input amount to a vehicle model representing the motion of the vehicle, and a damper controlling unit that controls the damping force of a damping-force-variable damper on the basis of the calculated state amount. If the wheel speed variation detected by the wheel speed sensor decreases below zero by a predetermined value or more on the minus side, the vertical load of the wheel is considered to be decreased, and the damping force is controlled to be greater than before the decrease.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: September 12, 2017
    Assignee: HONDA MOTOR CO., LTD.
    Inventors: Ryoma Kanda, Yukihiro Orimoto, Koichi Shibusawa, Tomohiro Yamazaki
  • Publication number: 20170199103
    Abstract: Provided is an examination method for a damping force variable mechanism, the examination method including: an operation step of operating a damper in a state in which the damper is installed in a vehicle, the damper being provided with a damping force variable mechanism that changes a damping force according to an input current (an example of a signal); and a detection step of detecting an induction current (an example of an output from the vehicle) from the damping force variable mechanism of the damper installed in the vehicle, wherein a detection device that performs the operation of the detection step is provided. Thus, the damping force variable mechanism of a pressure damping device can be examined in a state in which the damping force variable mechanism is installed in the vehicle.
    Type: Application
    Filed: February 2, 2015
    Publication date: July 13, 2017
    Applicants: Showa Corporation, Honda Motor Co., Ltd.
    Inventors: Seiryo KONAKAI, Ken ISSIKI, Ryoma KANDA, Yukihiro ORIMOTO, Koichi SHIBUSAWA, Tomohiro YAMAZAKI
  • Publication number: 20160318364
    Abstract: A suspension controller includes a wheel speed sensor that detects the wheel speed of each wheel, a basic input amount calculating unit that calculates the basic input amount of the vehicle on the basis of a wheel speed variation detected by the wheel speed sensor, a state amount calculating unit that calculates the state amount of the vehicle by inputting the basic input amount to a vehicle model representing the motion of the vehicle, and a damper controlling unit that controls the damping force of a damping-force-variable damper on the basis of the calculated state amount. If the wheel speed variation detected by the wheel speed sensor decreases below zero by a predetermined value or more on the minus side, the vertical load of the wheel is considered to be decreased, and the damping force is controlled to be greater than before the decrease.
    Type: Application
    Filed: April 27, 2016
    Publication date: November 3, 2016
    Applicant: HONDA MOTOR CO., LTD.
    Inventors: Ryoma Kanda, Yukihiro Orimoto, Koichi Shibusawa, Tomohiro Yamazaki
  • Patent number: 8557259
    Abstract: It is an object of the present invention to provide a liquid preparation which excels in stability with no occurrence of precipitates and lees even after long storage. The liquid preparation contains a lipophilic material, a sucrose fatty acid ester, a polyoxyethylene hydrogenated castor oil, a polyglycerin fatty acid ester, a polyol and water. Also provided are a pharmaceutical preparation, cosmetic preparation, food and drink which contain the liquid preparation.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: October 15, 2013
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Norio Goto, Koichi Shibusawa
  • Publication number: 20060189662
    Abstract: It is an object of the present invention to provide a liquid preparation which excels in stability with no occurrence of precipitates and lees even after long storage. The liquid preparation contains a lipophilic material, a sucrose fatty acid ester, a polyoxyethylene hydrogenated castor oil, a polyglycerin fatty acid ester, a polyol and water. Also provided are a pharmaceutical preparation, cosmetic preparation, food and drink which contain the liquid preparation.
    Type: Application
    Filed: April 7, 2006
    Publication date: August 24, 2006
    Inventors: Norio Goto, Koichi Shibusawa
  • Patent number: 5035895
    Abstract: An aqueous solution comprises a fat-soluble substance, a phosphatide, a polyhydric alcohol and a basic amino acid, a salt thereof or Meglumin. It is uniformly emulsified and solubilized for the pharmaceutical use.
    Type: Grant
    Filed: January 20, 1989
    Date of Patent: July 30, 1991
    Assignee: Eisai Co., Ltd.
    Inventors: Koichi Shibusawa, Shigemitsu Ohsawa