Patent number: 5010093
Abstract: The invention relates to a nitric ester derivative with vasodilating properties for treatment of cardiovascular disorders, the derivative being of the formula ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, halo(lower)alkyl, halogen, phenyl, nitrophenyl, pyridyl, morpholino, piperidino, amino, lower alkanoylamino, higher alkanoylamino, benzamido, lower alkoxycarbonylamino, N-lower alkylamino, N,N-di(lower)alkylamino, N-lower alkyl-N-lower alkanoylamino, 3-lower alkylureido or N,N-di(lower) alkylamino(lower)alkyl,R.sup.2 is hydrogen, lower alkyl or N-(nitrooxy(lower)alkyl)carbamoyl,Y is a single bond, lower alkylene or lower alkenylene, andZ is ethylene, trimethylene, tetramethylene, 1-methylnitrooxymethylethylene, 1,1-bis(nitrooxy-methyl)ethylene, 2-nitrooxytrimethylene or ethyleneoxyethylene, and pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
March 16, 1990
Date of Patent:
April 23, 1991
Assignee:
Fujisawa Pharmaceutical Co., Ltd.
Inventors:
Youichi Shiokawa, Koichi Takimoto, Kohei Takenaka