Patents by Inventor Koichi Yokoi
Koichi Yokoi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5585511Abstract: A platinum complex represented by the following formula (1): ##STR1## wherein the all symbols are defined in the disclosure; and a malignant tumor treating drug which contains the complex as an active ingredient. The platinum complex is excellent in antitumor effects and safety and is highly soluble in water, and therefore it is useful as an agent for use in the treatment of various malignant tumors.Type: GrantFiled: December 26, 1995Date of Patent: December 17, 1996Assignee: SS Pharmaceutical Co., Ltd.Inventors: Koichi Yokoi, Kinichi Mogi, Hidehiko Kohya, Mari Ohtsuka, Hiroyuki Mizuno, Susumu Sato, Tadayuki Kuraishi
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Patent number: 5511440Abstract: A hollow steering shaft having a good quality can be manufactured at a low cost by passing a blank tube having a circular cross section through a preliminary shaping die and then through a finishing shaping die. The blank tube which has passed through the preliminary shaping die is formed with two kinds of convex curve surface portions having different radii of curvature and arranged continuously, circumferentially and alternately. When the blank tube passes through the finishing shaping die, the larger convex curve surface portions are deformed into flat portions. As a result, a steering shaft having an elliptical cross section is manufactured.Type: GrantFiled: August 10, 1994Date of Patent: April 30, 1996Assignee: NSK Ltd.Inventors: Yasushi Watanabe, Kiyoshi Okubo, Koichi Yokoi
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Patent number: 5498780Abstract: A diamine-platinum complex represented by the following formula (1): ##STR1## wherein the all definitions are defined in the disclosure, and a malignant tumor treating drug which contains the above complex as an active ingredient. The diamine-platinum complex has a high water solubility and an excellent antitumor effect.Type: GrantFiled: May 31, 1995Date of Patent: March 12, 1996Assignee: SS Pharmaceutical Co., Ltd.Inventors: Koichi Yokoi, Kinichi Mogi, Hidehiko Kohya, Mari Ohtsuka, Hiroyuki Mizuno, Susumu Sato, Tadayuki Kuraishi
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Patent number: 5114329Abstract: A mold unit for injection molding having an outer frame in two sections is capable of receiving inside molds with flanges. The inside molds with flanges are mounted and removed through the use of pressing mechanisms. The pressing mechanism secures the flanges of an inside mold by the use of a clamp bolt and allows for rotation so that the flange is slidable mounted in a simple manner.Type: GrantFiled: March 6, 1991Date of Patent: May 19, 1992Assignee: Sankyo Engineering Co., Ltd.Inventors: Susumu Nakamura, Koichi Yokoi
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Patent number: 5018899Abstract: A yoke for universal joint is composed of a cylindrical coupling tube formed by pressing a metal plate and having a slit in a radial direction and serrate grooves on the internal periphery; a pair of flanges integrally formed at an end of the coupling tube and positioned on both sides of the slit; and a coupling arm formed by pressing a metal plate. One of the flanges has a screw hole, while the other flange has a hole, coaxial with the screw hole, for passing a bolt to be screwed into the screw hole. The coupling arm has a penetrating hole in the base portion, and mutually coaxial circular holes at its opposite ends. The yoke is assembled by fitting the other end of the coupling tube into the penetrating hole in the base portion, and connecting the other end of the coupling tube with the base portion of the coupling arm.Type: GrantFiled: July 2, 1990Date of Patent: May 28, 1991Assignee: Nippon Seiko Kabushiki KaishaInventors: Ritsuo Kuribara, Kiyoshi Okubo, Koichi Yokoi, Kiyoshi Sadakata
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Patent number: 5008419Abstract: A platinum complex having the following formula (I) is disclosed, ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each independently represents a methyl group or an ethyl group, and the configuration of 1,2-diaminocyclohexane is either cis-, trans-l-, trans-d-, or trans-dl-.The compound possess excellent antitumor activity with a high therapeutic index and abundant water solubility, and thus are effective as an antitumor agent.Type: GrantFiled: December 18, 1989Date of Patent: April 16, 1991Assignee: SS Pharmaceutical Co., Ltd.Inventors: Koichi Yokoi, Kazuhiko Irinoda, Hidehiko Kohya, Susumu Sato, Tatsuhiko Katori
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Patent number: 4968825Abstract: A platinum complex having a superior antitumor activity is disclosed. The platinum complex has a structure represented by the formula: ##STR1## wherein A and B independently represent a lower alkanoyloxy group which may have a halogen atom substituent, or in combination represent a group: ##STR2## wherein R.sub.1 and R.sub.2 independently represent a hydrogen atom, a hydroxyl group, or a lower alkyl group, or in combination with each other and with the adjacent carbon atom a cyclobutane ring, and R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a sulfo group, or nitro group.Type: GrantFiled: October 6, 1989Date of Patent: November 6, 1990Assignee: SS Pharmaceutical Co., Ltd.Inventors: Koichi Yokoi, Kinichi Mogi, Kazuhiko Irinoda, Hidehiko Kohya, Susumu Sato, Tatsuhiko Katori
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Patent number: 4917595Abstract: A nozzle touch sprue bushing device for a unit-type injection metal mold which includes a molding body such as a metal mold including an inner mold element which is removably mounted on an outer frame mounted on an injecting molding machine, wherein a sprue bush has a nozzle touch provided at a rear end thereof for fitting with an end of a nozzle of an injecting machine, and has a front end formed in such a fitting configuration as to allow fitting engagement thereof with a material admitting portion of a metal mold.Type: GrantFiled: December 2, 1988Date of Patent: April 17, 1990Assignee: Sankyo Engineering Co., Ltd.Inventors: Susumu Nakamura, Koichi Yokoi, Hajime Nakamura
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Patent number: 4904809Abstract: A platinum complex having a superior antitumor activity is disclosed. The platinum complex has a structure represented by the formula: ##STR1## wherein A and B independently represent a lower alkanoyloxy group which may have a halogen atom substituent, or in combination represent a group: ##STR2## wherein R.sub.1 and R.sub.2 independently represent a hydrogen atom, a hydroxyl group, or a lower alkyl group, or in combination with each other and with the adjacent carbon atom a cyclobutane ring, and R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a sulfo group, or nitro group.Type: GrantFiled: September 16, 1988Date of Patent: February 27, 1990Assignee: SS Pharmaceutical Co., Ltd.Inventors: Koichi Yokoi, Kinichi Mogi, Kazuhiko Irinoda, Hidehiko Kohya, Susumu Sato, Tatsuhiko Katori
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Patent number: 4902212Abstract: A self-lubricating metallic matrix for injection molding, the matrix having an element having a lubrication requiring sliding wall in which a plurality of receiving holes are formed in such a positional relationship that end faces thereof may be positioned in a partially overlapping relationship with each other in the direction of such sliding movement, and a solid lubricant received in the receiving holes of the element.Type: GrantFiled: December 5, 1988Date of Patent: February 20, 1990Assignee: Sankyo Engineering Co., Ltd.Inventors: Susumu Nakamura, Koichi Yokoi
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Patent number: 4889480Abstract: A slide core mold for injection molding wherein a slider block provided in its front surface with an undercut core is slidably provided on the side of a core mold, a pressure receiving inclined surface provided with guide grooves in opposite sides being provided at the back thereof, projections fitted into said guide grooves are provided on opposite sides at a corresponding position of a cavity mold corresponding thereto, a block body formed in its front surface with a pressing inclined surface in contact with the pressure receiving inclined surface of the back of the slider block is projected, and the slider block is reciprocated in association with engagement and disengagement of the core mold and the cavity mold.Type: GrantFiled: December 2, 1988Date of Patent: December 26, 1989Assignee: Sankyo Engineering Co., Ltd.Inventors: Susumu Nakamura, Koichi Yokoi
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Patent number: 4835287Abstract: A substance SS42227 represented by the following formula (I): ##STR1## in which X represents >CH.sub.2 or >C=CHOH. The substance has antimicrobial and antitumor activities, and thus is useful as a medicine.Type: GrantFiled: July 20, 1987Date of Patent: May 30, 1989Assignee: SS Pharmaceutical Co., Ltd.Inventors: Katsuhiko Nagaoka, Masaru Matsumoto, Koichi Yokoi, Junji Oono, Kenichi Kukita, Toshiaki Nakashima
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Patent number: 4584377Abstract: Disclosed herein are Fredericamycin A derivatives, each, represented by the following general formula (I): ##STR1## wherein R means a hydrogen atom or acyl group, A denotes ##STR2## and dotted bonds are optional, with a proviso that when A is ##STR3## or the dotted bonds are contained, R is other than hydrogen atom. They have excellent antibacterial and antitumor activities and at the same time, are extremely stable compared with Fredericamycin A.Type: GrantFiled: August 9, 1984Date of Patent: April 22, 1986Assignee: SS Pharmaceutical Co., Ltd.Inventors: Koichi Yokoi, Hiroshi Hasegawa, Tadashi Narita, Takemitsu Asaoka, Kenichi Kukita, Seiji Ishizeki, Toshiaki Nakashima
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Patent number: 4501752Abstract: An antiulcer drug comprising Ikarugamycin as its active ingredient is disclosed.Type: GrantFiled: April 22, 1983Date of Patent: February 26, 1985Assignee: SS Pharmaceutical Co., Ltd.Inventors: Koichi Yokoi, Koichi Tachibana, Kazuo Isomae, Toshiaki Nakashima