Abstract: The present inventors found cyclic peptide compounds that interact with Ras, and pharmaceutical compositions containing the cyclic peptide compounds or salts thereof, or solvates thereof.

Abstract: The present invention provides a method for screening for platelet production promoters, the method including a step for selecting a candidate substance that significantly increases expression of TUBB1 as a platelet production promoter.

Abstract: A motor control method for transferring an object to be transferred by a moving object that moves by driving of a motor in a substrate processing apparatus, includes: a data acquisition process of acquiring, at different times, pieces of drive data which relate to the driving of the motor and vary with heat generation of the motor; and a transfer process of transferring the object to be transferred by controlling current to be supplied to the motor, based on each of the pieces of drive data, to compensate for displacement of the object to be transferred from a target transfer position due to the heat generation of the motor.

Abstract: According to one embodiment, a method of quantifying a target nucleic acid containing a first sequence in a sample is provided. The method includes preparing a substrate on which a plurality of detection regions are arranged, forming a reaction field by placing, on the substrate, a reaction liquid containing a sample, a primer set, and an amplification enzyme, maintaining the reaction field in an isothermal amplification condition, detecting a detection signal for each of the detection regions, determining, for each of the plurality of detection regions, whether positive or negative and detecting or quantifying the target nucleic acid based on the number of positive and/or a rise time of each of the positive detection signal.

Abstract: Healthy functional platelets are mass produced. A method for producing platelets, comprising: (1) a culture step of culturing megakaryocytes in a platelet producing medium in the presence of mechanical stress and platelet production promoting factors including MIF, NRDc, IGFBP2, TSP-1, PAI-1, and CCL5, and (2) a harvest step of harvesting the platelets obtained by the culture step; wherein the culture step comprises: (a) a step of promoting a release of the platelet production promoting factors from megakaryocytes by mechanical stress; and/or (b) a step of externally adding platelet production promoting factors including MIF, NRDc, and IGFBP2.

Abstract: Thermosensitive fine particles of the present invention include a side chain crystal polymer which is crystallized at a temperature lower than a melting point and which exhibits fluidity at a temperature equal to or more than the melting point. The side chain crystal polymer may include, as a monomer component, a (meth)acrylate having a straight-chain alkyl group having 14 or more carbon atoms. A mean particle diameter of the fine particles may be 0.1 to 50 ?m. The thermosensitive fine particles may include no organic solvents.

Abstract: A control device includes a controller that executes determining a connection between a first unit that has a boarding space which allows a user to board and is provided with a predetermined facility and that is provided with a first path through which a fluid used in the predetermined facility passes and a second unit that is configured to be separated from and connected to the first unit and that has a drive device of a vehicle that is formed by being connected to the first unit, and supplying the fluid in the first path to a second unit side to absorb heat generated from the drive device.

Abstract: A multilayer tube (1) includes: an elastic layer (11, 21, 31, 41, 51) formed over the entire length of the multilayer tube (1) and having a predetermined flexural modulus of elasticity; and a hard layer (12, 22, 32, 42, 52) formed over the entire length of the multilayer tube (1), having a flexural modulus of elasticity that is high compared to the elastic layer (11, 21, 31, 41, 51), and disposed more to an outer layer side than the elastic layer (11, 21, 31, 41, 51). A first extremity (10) of the multilayer tube (1) is formed in such a manner that the thickness (H11) of the elastic layer (11) is thicker than the thickness (H12) of the hard layer (12).

Abstract: A flight support apparatus includes a flight support unit that displays a reference flight profile that is a flight profile as a reference, the flight profile indicating a flight specification at a plurality of spots included in a path from a departure place to a destination, corrects the reference flight profile according to a flight condition input by a user to prepare a corrected flight profile, and displays the prepared corrected flight profile together with the reference flight profile.

Abstract: A drive unit includes an actuator from which an output rod protrudes at one end of a cylinder and being coupled to a flap of an aircraft, an attachment disposed on the other side of the cylinder, a reaction link coupled to the flap at one end and to the attachment at the other end, and a connection-disconnection section allowing the cylinder and the attachment to be coupled to and separated from each other.

Abstract: The present invention provides a compound of general formula (I) (wherein X is as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.

Abstract: A method can include receiving neutron data and density data for a borehole in a geologic formation; determining a migration length value for a layer of the geologic formation based at least in part on the neutron data; forward modeling at least the layer based at least in part on the migration length value and the density data; and outputting, based at least in part on the forward modeling, modeled neutron data for the layer.

Abstract: An aspect of the present invention provides a pickup system which makes, even in a case of transporting a load by using a single unmanned flying object, the unmanned flying object and the load less likely to tilt. A pickup system (1) includes: a holder (11) for holding a load (L); a measuring instrument (14) for measuring the position of the center of gravity of the holder (11) holding the load (L); and a controller (15) for moving, to a position immediately above the position of the center of gravity of the holder (11) holding the load (L), a connector (12) which is attached to the holder (11) in a movable manner and which is for connecting the holder (11) to a drone (D).

Abstract: The semiconductor device includes a mesa diode structure(20) and a protective layer(17b). The mesa diode structure includes, from bottom to top, a P-type semiconductor layer(11), a first N-type semiconductor layer(12), and a second N-type semiconductor layer(13) having a higher impurity concentration than the first N-type semiconductor layer. The protective layer is arranged on a side wall around the mesa diode structure seen in a plane. Specifically, the protective layer is arranged on an upper side surface(11c) of the P-type semiconductor layer and on side surfaces(12a,13a) of the first N-type semiconductor layer and the second N-type semiconductor layer, but is not arranged on a lower side surface of the P-type semiconductor layer. A bevel angle(30) of a PN junction plane between the P-type semiconductor layer and the first N-type semiconductor layer to the upper side surface of the P-type semiconductor layer is set to 85 to 120 degrees.

Abstract: Provided is a test apparatus for an actuator, which can easily switch whether to establish or undo the coupling between an actuator to be tested and a load part configured to apply load to the actuator. A test apparatus for an actuator includes a load part for outputting load to be applied to an actuator to be tested, first levers for swinging around a rotational shaft in connection with an output from the load part, an idler link coupled to the output from the actuator to be tested, a second lever coupled to the idler link in a swingable manner and for swinging around a rotational shaft that is arranged coaxially with the rotational shaft of the first levers, and a clutch mechanism for coupling together the first levers and the second lever and undoing the coupling.

Abstract: A method can include receiving neutron data and density data for a borehole in a geologic formation; determining a migration length value for a layer of the geologic formation based at least in part on the neutron data; forward modeling at least the layer based at least in part on the migration length value and the density data; and outputting, based at least in part on the forward modeling, modeled neutron data for the layer.

Abstract: A vehicle control device includes at least one ECU configured to: when charging the first battery from the power generation device is possible and a restriction on operation of the power generation device is predicted during traveling, control the power generation unit such that the first battery is charged from the power generation device and control the power generation unit such that the second battery is charged in a case where an SOC of the first battery is equal to or higher than a threshold; and when the charging is not possible, the SOC of the first battery is equal to or lower than a threshold and an SOC of the second battery is equal to or higher than a threshold and the restriction is predicted during traveling, control the power generation unit such that the first battery is charged from the second battery.

Abstract: A secondary battery management device is connected with electronic equipment using a secondary battery as a driving power supply via the Internet. The secondary battery management device acquires performance information of the secondary battery from the electronic equipment, and measures a degradation level of performance of the secondary battery during a predetermined unit period. The secondary battery management device estimates a degrading speed of the secondary battery on the basis of the degradation level. The secondary battery management device may notify a user of the electronic equipment of the replacement timing of the secondary battery, use fees of the secondary battery, and the like.

Abstract: Data corresponding to an image selected by a user is transmitted to a printing apparatus by a program being executed, and it is determined whether printing based on the data has been completed by the printing apparatus. Then, an input screen for the user to input a rating of the program is displayed on a display used by an information processing apparatus on a condition that the printing has been determined as having been completed.

Abstract: A method can include receiving data for a geologic region; based at least in part on the data, selecting a model from a plurality of models using a trained machine learning model, and inverting the data using the selected model to determine parameters of the selected model.