Abstract: There is provided a canceration information providing method which can detect the possibility of cancer in the initial stage with high accuracy. The canceration information providing method for providing information pertaining to canceration of cells includes: acquiring measurement data including first data pertaining to size of a cell nucleus and second data pertaining to size of a cytoplasm for each cell contained in a measurement sample which includes cells collected from epithelial tissue; extracting the measurement data of cells to be analyzed, which are at least some of the cells located toward the basal membrane side of the cells existing in the surface layer in the epithelial tissue, from the measurement data of a plurality of cells in the measurement sample based on the first data and the second data acquired for each cell; and analyzing the extracted measurement data and outputting the information pertaining to the canceration of cells.

Abstract: Provided is a canceration information providing method capable of presenting the information related to canceration of the cells with high reliability. A cell in which the amount of DNA is greater than or equal to the amount of DNA of the normal cell in the S period is extracted from a cell group of V11?N/C ratio?V12 (first counting step). If the number of cells obtained in the first counting step is greater than or equal to the threshold value S1 (S107: YES), “Cancer” is set to a flag 1. A cell in which the amount of DNA is 2C is extracted from a cell group of V13?N/C ratio?V11 (second counting step). A ratio of the number of cells obtained in the second counting step and number of cells obtained in the first counting step is calculated, and “Cancer” is set to a flag 2 if the ratio is greater than or equal to a threshold value S2 (S111: YES). If one of the flags 1, 2 is “Cancer” (S113: YES), the display of retest necessary is performed.

Abstract: Provided is a canceration information providing method capable of presenting information related to canceration of cells with high reliability. A cell in which an amount of DNA is greater than or equal to an amount of DNA of a normal cell in a S period is extracted from a cell group of V11?N/C ratio?V12 (first counting step). If a number of cells obtained in the first counting step is greater than or equal to a threshold value S1 (S107: YES), “Cancer” is set to a flag 1. A cell in which an amount of DNA is 2C is extracted from a cell group of V13?N/C ratio<V11 (second counting step). A ratio of a number of cells obtained in the first counting step and a number of cells obtained in the second counting step is calculated, and “Cancer” is set to a flag 2 if the ratio is greater than or equal to a threshold value S2 (S111: YES). If either one of the flags 1, 2 is “Cancer” (S113: YES), retest necessary is displayed.

Abstract: A sample preparation device includes: a filter member including a filter configured to separate cells being an analysis target from other components in a sample; a first receptacle and a second receptacle configured to be connected to each other via the filter; a third receptacle capable of holding the sample therein; a negative pressure section configured to apply a negative pressure into the second receptacle, thereby to move the sample in the third receptacle toward the filter via the first receptacle, and thereby to move components other than the analysis target into the second receptacle via the filter; and a positive pressure section configured to apply a positive pressure from the second receptacle side to the filter to which cells being the analysis target are attached.

Abstract: A cell processing apparatus includes a storage container that contains liquid L including a biological sample; a filter that prevents a first cell C1 in the biological sample from passing and allows a second cell C2 having a smaller diameter than that of the first cell C1 to pass; and a filtration cylinder for separating, in the storage container and via the filter, the liquid L into a first liquid L1 mainly including the first cell C1 and a second liquid L2 mainly including the second cell C2. A measurement target cell filtered by the filter among other cells can be easily collected.

Abstract: A sample preparation apparatus comprising: a filter which separates predetermined cells from a liquid sample containing a plurality types of cells; a rotor which includes a magnetic body and detaches the predetermined cells attached to the filter by rotation; a driving unit which rotates the rotor using a magnetic force; and a rotation information acquiring unit which acquires a rotation information of the rotor when the driving unit rotates the rotor. A method and a computer program product are also disclosed.

Abstract: A sample preparation device includes: a filter member including a filter configured to separate cells being an analysis target from other components in a sample; a first receptacle and a second receptacle configured to be connected to each other via the filter; a third receptacle capable of holding the sample therein; a negative pressure section configured to apply a negative pressure into the second receptacle, thereby to move the sample in the third receptacle toward the filter via the first receptacle, and thereby to move components other than the analysis target into the second receptacle via the filter; and a positive pressure section configured to apply a positive pressure from the second receptacle side to the filter to which cells being the analysis target are attached.

Abstract: A sample preparation apparatus, comprising: an ultrasonic vibrating unit which applies ultrasonic vibration to a sample including an analyte held in a measurement sample container; a sample preparation unit which prepares a measurement sample by mixing the sample including the analyte to which the ultrasonic vibration is applied and a predetermined reagent; and a container transporting unit which transports the measurement sample container holding the sample including the analyte from the ultrasonic vibrating unit to the sample preparation unit.

Abstract: The present invention provides a cell analyzer which comprises: a cell dispersion unit which causes aggregated cells in a biological specimen to be dispersed, through a shearing force applying process of applying a shearing force to the aggregated cells and an ultrasonic dispersion process of dispersing the aggregated cells, by using ultrasonic waves; a detection unit which detects characteristics information reflecting properties of the cells in the biological specimen on which the shearing force applying process and the ultrasonic dispersion process have been performed; and an analysis unit which analyzes the cells in the biological specimen, based on a detection result from the detection unit.

Abstract: A sample preparation apparatus comprising: a storage chamber that can store therein a liquid sample including an analysis target to be analyzed; a concentrated sample storage chamber that is provided to communicate with the storage chamber and that stores therein concentrated liquid having an analysis target having a higher concentration than that of the liquid sample; and an analysis target transportation section for transporting the analysis target included in the liquid sample stored in the storage chamber to the concentrated sample storage chamber. A cell analyzer is also disclosed.

Abstract: There is provided a canceration information providing method which can detect the possibility of cancer in the initial stage with high accuracy. The canceration information providing method for providing information pertaining to canceration of cells includes: acquiring measurement data including first data pertaining to size of a cell nucleus and second data pertaining to size of a cytoplasm for each cell contained in a measurement sample which includes cells collected from epithelial tissue; extracting the measurement data of cells to be analyzed, which are at least some of the cells located toward the basal membrane side of the cells existing in the surface layer in the epithelial tissue, from the measurement data of a plurality of cells in the measurement sample based on the first data and the second data acquired for each cell; and analyzing the extracted measurement data and outputting the information pertaining to the canceration of cells.

Abstract: A sample preparation apparatus is provided. The apparatus comprises a first receiving part, a second receiving part, a filter part, a third receiving part, a flow path, a first moving means and a second moving means. The first receiving part is configured to accept a pipette and to receive a sample discharged from a pipette. The second receiving part is disposed at a position removed from the first receiving part in the plane of view. The filter part is configured to retain the cells to be analyzed within the second receiving part. The third receiving part is disposed opposite the second receiving part through the filter part The flow path is configured to connect the first receiving part and the second receiving part The first moving means is for moving a sample that has been received at the first receiving part to the filter part through the flow path and the second receiving part, and moving the components other than the cells to be analyzed to the third receiving part through the filter part.

Abstract: A cell processing apparatus includes a storage container that contains liquid L including a biological sample; a filter that prevents a first cell C1 in the biological sample from passing and allows a second cell C2 having a smaller diameter than that of the first cell C1 to pass; and a filtration cylinder for separating, in the storage container and via the filter, the liquid L into a first liquid L1 mainly including the first cell C1 and a second liquid L2 mainly including the second cell C2. A measurement target cell filtered by the filter among other cells can be easily collected.

Abstract: A cell processing apparatus 29 of the present invention includes a storage container 57 that can contain liquid L including a biological sample; a filter 60 that prevents a first cell C1 in the biological sample from passing therethrough and that allows a second cell C2 having a smaller diameter than that of the first cell C1 to pass therethrough; and a filtration cylinder 58 for separating, in the storage container 57 and via the filter 60, the liquid L into a first liquid L1 mainly including the first cell C1 and a second liquid L2 mainly including the second cell C2. A measurement target cell discriminated by the filter from the other cells can be easily collected.

Abstract: A flow cytometer is provided comprising a sample nozzle, a flow cell with a first flow pass arranged downstream from the sample nozzle, a sample nozzle receiver with a second flow pass, with a sample nozzle arranged within the second flow pass, a measurement sample supplier, and a sheath fluid supplier, wherein at least a part of the sample nozzle receiver comprises a tapered part for narrowing the second flow pass in the direction toward the first flow pass and the tapered part has a first tapered part with an aspect ratio that is larger than 1 in the transverse section of the flow pass interesting to the flow direction of the measurement sample, and the end on the downstream side of the sample nozzle is arranged at the first tapered part of the tapered part.

Abstract: A sample preparation apparatus, comprising: an ultrasonic vibrating unit which applies ultrasonic vibration to a sample including an analyte held in a measurement sample container; a sample preparation unit which prepares a measurement sample by mixing the sample including the analyte to which the ultrasonic vibration is applied and a predetermined reagent; and a container transporting unit which transports the measurement sample container holding the sample including the analyte from the ultrasonic vibrating unit to the sample preparation unit.

Abstract: A sample preparation apparatus comprising: a filter which separates predetermined cells from a liquid sample containing a plurality types of cells; a rotor which includes a magnetic body and detaches the predetermined cells attached to the filter by rotation; a driving unit which rotates the rotor using a magnetic force; and a rotation information acquiring unit which acquires a rotation information of the rotor when the driving unit rotates the rotor. A method and a computer program product are also disclosed.

Abstract: A sample preparation apparatus comprising: a storage chamber that can store therein a liquid sample including an analysis target to be analyzed; a concentrated sample storage chamber that is provided to communicate with the storage chamber and that stores therein concentrated liquid having an analysis target having a higher concentration than that of the liquid sample; and an analysis target transportation section for transporting the analysis target included in the liquid sample stored in the storage chamber to the concentrated sample storage chamber. A cell analyzer is also disclosed.

Abstract: A cell processing apparatus 29 of the present invention includes a storage container 57 that can contain liquid L including a biological sample; a filter 60 that prevents a first cell C1 in the biological sample from passing therethrough and that allows a second cell C2 having a smaller diameter than that of the first cell C1 to pass therethrough; and a filtration cylinder 58 for separating, in the storage container 57 and via the filter 60, the liquid L into a first liquid L1 mainly including the first cell C1 and a second liquid L2 mainly including the second cell C2. A measurement target cell discriminated by the filter from the other cells can be easily collected.