Abstract: Systems and methods for virtual pancreatography (VP) are disclosed for non-invasive diagnosis and classification of pancreatic lesions. VP is an end-to-end visual diagnosis system that includes: automatic segmentation of the pancreatic gland and the lesions, extraction of the primary pancreatic duct, automatic classification of lesions into a plurality of lesion types, and specialized 3D and 2D exploratory visualizations of the pancreas, lesions and surrounding anatomy. Volume rendering is combined with pancreas and lesion centric visualizations and measurements for effective diagnosis.