Patents by Inventor Koppaka V. Rao

Koppaka V. Rao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the isolation and purification of taxol and its natural analogues
    Patent number: 5670673
    Abstract: An improved method for isolating taxol and certain clinically important analogues of taxol from a crude extract of a naturally occurring Taxus species comprising treating the extract by reverse phase liquid chromatography on an adsorbent, causing the taxol and the taxol analogues to be adsorbed on the adsorbent, and recovering taxol and the natural analogues of taxol from the adsorbent by elution with an elutant. The compounds thus isolated in pure form are taxol, taxol-7-xyloside, 10-deacetyltaxol, 10-deacetyltaxol-7-xyloside, cephalomannine, cephalomannine-7-xyloside, 10-deacetylcephalomannine-7-xyloside, baccatin III, 10-deacetylbaccatin III, baccatin VI, brevitaxane A, and taxiflorine.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: September 23, 1997
    Assignee: University of Florida
    Inventor: Koppaka V. Rao
  • Method for the isolation and purification of taxol and its natural analogues
    Patent number: 5475120
    Abstract: An improved method for isolating taxol and certain clinically important analogues of taxol from a crude extract of a naturally occuring Taxus species comprising treating the extract by reverse phase liquid chromatography on an adsorbent, causing the taxol and the taxol analogues to be absorbed on the adsorbent, and recovering taxol and the natural analogues of taxol from the adsorbent by elution with an elutant. The compounds thus isolated in pure form are taxol, taxol-7- xyloside, 10-deacetyltaxol, 10-deacetyltaxol-7-xyloside, cephalomannine, cephalomannine-7-xyloside, 10-deacetylcephalomannine-7-xyloside, baccatin III, 10-deacetylbaccatin III, baccatin VI, brevitaxane A, and taxiflorine.
    Type: Grant
    Filed: November 2, 1994
    Date of Patent: December 12, 1995
    Assignee: University of Florida
    Inventor: Koppaka V. Rao
  • Method for the isolation and purification of taxane derivatives
    Patent number: 5380916
    Abstract: An improved method for isolating certain clinically important taxane derivatives from the crude extract of a naturally occurring Taxus species comprising treating the extract by reverse phase liquid chromatography on an adsorbent; causing the taxane derivatives to be adsorbed on the adsorbent; and recovering the taxane derivatives from the adsorbent by elution with an elutant. The taxane derivatives thus isolated in pure form are taxol, taxol-7-xyloside, 10-deacetyitaxol, 10-deacetyltaxol-7-xyloside, cephalomannine, cephalomannine-7-xyloside, 10-deactylcephalomannine-7-xyloside, baccatin III, 10-deacetylbaccatin III, baccatin VI, and brevitaxane A.
    Type: Grant
    Filed: July 16, 1992
    Date of Patent: January 10, 1995
    Assignee: University of Florida
    Inventor: Koppaka V. Rao
  • Process for the preparation of taxol and 10-deacetyltaxol
    Patent number: 5367086
    Abstract: Taxol, 10-deacetyltaxol and other taxane derivatives are prepared from naturally occurring taxane-7-xylosides by the oxidative cleavage of the 7-xyloside moieties.
    Type: Grant
    Filed: March 10, 1993
    Date of Patent: November 22, 1994
    Assignee: University of Florida
    Inventor: Koppaka V. Rao
  • Process for the preparation of taxol and 10-deacetyltaxol
    Patent number: 5200534
    Abstract: Taxol, 10-deacetyltaxol and other taxane derivatives are prepared from naturally occurring taxane-7-xylosides by the oxidative-cleavage of the 7-xyloside moieties.
    Type: Grant
    Filed: March 13, 1992
    Date of Patent: April 6, 1993
    Assignee: University of Florida
    Inventor: Koppaka V. Rao
  • Neolignans of Saururus cernuus L and analogues thereof
    Patent number: 4619943
    Abstract: Novel phenylpropanoid neolignans isolated from Saururus cernuus L and synthetic or semi-synthetic analogs thereof having neuroleptic, insecticidal, or nematicidal activity are disclosed.
    Type: Grant
    Filed: September 10, 1984
    Date of Patent: October 28, 1986
    Inventor: Koppaka V. Rao