Abstract: A system for generating an overdose risk score of a user includes a physiological sensor coupled to a wearable device and configured to detect attenuated light from a tissue site of the user and at least one hardware processor. The hardware processor can be configured to determine a plurality of parameters based on the attenuated light, determine a baseline risk, an instability index, an average slope, and desaturation pressure, and determine a weighted aggregate of the baseline risk, the instability index, the average slope, and the desaturation pressure for each of the plurality of parameters, determine an overdose risk score by determining a weighted aggregate of the plurality of parameters, determine an alarm level of a series of escalating alarm levels based on the overdose risk score, and implement intervention associated with the determined alarm level.

Abstract: A system for critical time-based opioid monitoring system includes a physiological monitoring system having a sensor and a system processing board, a computing device configured to receive the parameters, an indication of normal conditions of a user under the circumstances at the time, such as, for example, a body transfer function or user physiological parameter model, to compare the monitored parameters to the normal conditions, and sending a notification when the monitored parameters deviate from the normal condition of a user. A system to monitor for an opioid event includes a physiological monitoring system comprising a sensor configured to monitor physiological parameters and a signal processing board, a computing device to detect an opioid overdose, and a device to stimulate a response when the computing device detects an opioid overdose event is occurring.