Abstract: To provide a tubular container which has non-absorbing properties with respect to contents as well as gas barrier properties. A tubular container 1 comprises at least an outlet unit 20 provided with an outlet part 21 through which contents are dispensed and a shoulder part 24 that extends radially outward from the outlet part 21; and a body part 10 that is welded to the shoulder part 24 of the outlet unit 20 and stores the contents therein, wherein the body part 10 comprises at least an innermost layer formed from a non-absorbing resin on an inner side that comes into contact with the contents, an outermost layer formed on an outermost side, and an intermediate layer formed between the innermost layer and the outermost layer and including a gas barrier layer. This tubular container 1 is characterized by a structural form wherein all surfaces coming into contact with the contents are formed from a non-absorbing resin or a structural form with a transparent body part including a gas barrier layer.

Abstract: To provide a tubular container which has non-absorbing properties with respect to contents as well as gas barrier properties. A tubular container 1 comprises at least an outlet unit 20 provided with an outlet part 21 through which contents are dispensed and a shoulder part 24 that extends radially outward from the outlet part 21; and a body part 10 that is welded to the shoulder part 24 of the outlet unit 20 and stores the contents therein, wherein the body part 10 comprises at least an innermost layer formed from a non-absorbing resin on an inner side that comes into contact with the contents, an outermost layer formed on an outermost side, and an intermediate layer formed between the innermost layer and the outermost layer and including a gas barrier layer. This tubular container 1 is characterized by a structural form wherein all surfaces coming into contact with the contents are formed from a non-absorbing resin or a structural form with a transparent body part including a gas barrier layer.

Abstract: The present invention provides a thrombin derivative, comprising an A chain and a B chain, the B chain having an amino acid sequence in which one or more kinds of active center amino acids selected from the group consisting of serine at position 205, glycine at position 203, aspartic acid at position 99, and histidine at position 43 in an amino acid sequence of a thrombin B chain are substituted, having the properties: (1) cleaving a thrombin substrate at the ratio of 10% or less when it is reacted with the thrombin substrate in 50 mM Tris-HCl (pH 7.4) containing 0.1 M NaCl at 37° C. for 3 hours, and (2) maintaining a structure of exosite I.