Patents by Inventor Kosuke Kawada
Kosuke Kawada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10087147Abstract: Provided are 5-(trifluoromethyl)pyrimidine derivatives useful as intermediates for pharmaceuticals and agrochemicals and as intermediates for electronic materials and methods for producing the same. 2,4-dichloro-5-(trifluoromethyl)pyrimidine is reacted with 2,2,2-trifluoroethanol, benzyl alcohol, or benzenethiol to obtain the intended 2-(2,2,2-trifluoroethoxy)-4-chloro-5-(trifluoromethyl)pyrimidine, 2-benzyloxy-4-chloro-5-(trifluoromethyl)pyrimidine, 2,4-bis(2,2,2-trifluoroethoxy)-5-(trifluoromethyl)pyrimidine, or 2-chloro-4-phenylthio-5-(trifluoromethyl)pyrimidine.Type: GrantFiled: April 14, 2017Date of Patent: October 2, 2018Assignee: TOSOH F-TECH, INC.Inventors: Takumi Kagawa, Daiki Shigehiro, Kosuke Kawada
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Publication number: 20170217906Abstract: Provided are 5-(trifluoromethyl)pyrimidine derivatives useful as intermediates for pharmaceuticals and agrochemicals and as intermediates for electronic materials and methods for producing the same. 2,4-dichloro-5-(trifluoromethyl)pyrimidine is reacted with 2,2,2-trifluoroethanol, benzyl alcohol, or benzenethiol to obtain the intended 2-(2,2,2-trifluoroethoxy)-4-chloro-5-(trifluoromethyl)pyrimidine, 2-benzyloxy-4-chloro-5-(trifluoromethyl)pyrimidine, 2,4-bis(2,2,2-trifluoroethoxy)-5-(trifluoromethyl)pyrimidine, or 2-chloro-4-phenylthio-5-(trifluoromethyl)pyrimidine.Type: ApplicationFiled: April 14, 2017Publication date: August 3, 2017Inventors: Takumi Kagawa, Daiki Shigehiro, Kosuke Kawada
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Patent number: 9656970Abstract: Provided are 5-(trifluoromethyl)pyrimidine derivatives useful as intermediates for pharmaceuticals and agrochemicals and as intermediates for electronic materials and methods for producing the same. 2,4-dichloro-5-(trifluoromethyl)pyrimidine is reacted with 2,2,2-trifluoroethanol, benzyl alcohol, or benzenethiol to obtain the intended 2-(2,2,2-trifluoroethoxy)-4-chloro-5-(trifluoromethyl)pyrimidine, 2-benzyloxy-4-chloro-5-(trifluoromethyl)pyrimidine, 2,4-bis(2,2,2-trifluoroethoxy)-5-(trifluoromethyl)pyrimidine, or 2-chloro-4-phenylthio-5-(trifluoromethyl)pyrimidine.Type: GrantFiled: April 23, 2015Date of Patent: May 23, 2017Assignee: TOSOH F-TECH, INC.Inventors: Takumi Kagawa, Daiki Shigehiro, Kosuke Kawada
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Publication number: 20160376241Abstract: Provided are 5-(trifluoromethyl)pyrimidine derivatives useful as intermediates for pharmaceuticals and agrochemicals and as intermediates for electronic materials and methods for producing the same. 2,4-dichloro-5-(trifluoromethyl)pyrimidine is reacted with 2,2,2-trifluoroethanol, benzyl alcohol, or benzenethiol to obtain the intended 2-(2,2,2-trifluoroethoxy)-4-chloro-5-(trifluoromethyl)pyrimidine, 2-benzyloxy-4-chloro-5-(trifluoromethyl)pyrimidine, 2,4-bis(2,2,2-trifluoroethoxy)-5-(trifluoromethyl)pyrimidine, or 2-chloro-4-phenylthio-5-(trifluoromethyl)pyrimidine.Type: ApplicationFiled: April 23, 2015Publication date: December 29, 2016Inventors: Takumi Kagawa, Daiki Shigehiro, Kosuke Kawada
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Patent number: 7615669Abstract: The present invention provides a process for producing highly pure fluoro-compounds by making use of N-(2-chloro-1,1,2-trifluoroethyl)diethylamine. The process produces little or no chlorinated by-products.Type: GrantFiled: March 22, 2006Date of Patent: November 10, 2009Assignee: Tosoh F-Tech, Inc.Inventors: Norihisa Kondo, Akio Watanabe, Hiroki Kanezaki, Kosuke Kawada
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Publication number: 20090030228Abstract: The present invention provides a process for producing highly pure fluoro-compounds by making use of less costly and readily handleable N-(2-chloro-1,1,2-trifluoroethyl)diethylamine. The process produces little or no chlorinated by-products.Type: ApplicationFiled: March 22, 2006Publication date: January 29, 2009Inventors: Norihisa Kondo, Akio Watanabe, Hiroki Kanezaki, Kosuke Kawada
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Patent number: 7476768Abstract: A catalyst for oxidizing 2,2,2-trifluoroethanol to form trifluoroacetaldehyde. The catalyst has a long life and achieves high conversion and selectivity. The catalyst of the present invention comprises one or more metal oxides, including at least vanadium oxide, and zirconia as a carrier.Type: GrantFiled: November 29, 2005Date of Patent: January 13, 2009Assignee: Tosoh F-Tech, Inc.Inventors: Hideyuki Mimura, Akio Watanabe, Noritaka Nagasaki, Kosuke Kawada
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Publication number: 20080132727Abstract: A catalyst for oxidizing 2,2,2-trifluoroethanol to form trifluoroacetaldehyde. The catalyst has a long life and achieves high conversion and selectivity. The catalyst of the present invention comprises one or more metal oxides, including at least vanadium oxide, and zirconia as a carrier.Type: ApplicationFiled: November 29, 2005Publication date: June 5, 2008Inventors: Hideyuki Mimura, Akio Watanabe, Noritaka Nagasaki, Kosuke Kawada
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Patent number: 7220878Abstract: The present invention concerns a method for purifying/separating a 2-fluoro-3-oxoalkylcarboxylic acid ester from a reaction mixture resulting from the fluorination of a 3-oxoalkylcarboxylic acid ester. The method involves depleting the reaction mixture of a hydrogen fluoride byproduct; and subsequently, separating the 2-fluoro-3-oxoalkylcarboxylic acid ester by distillation. The 2-fluoro-3-oxoalkylcarboxylic acid ester obtained by the method of the invention is highly pure and is thus suitable for use as an intermediate for the production of pharmacological products or agricultural chemicals.Type: GrantFiled: September 27, 2001Date of Patent: May 22, 2007Assignee: Tosoh F-Tech, Inc.Inventors: Norihisa Kondo, Hideyuki Mimura, Kosuke Kawada, Shoji Arai
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Publication number: 20060183937Abstract: An ?-pentafluoroethyl acrylic acid derivative represented by the general formula [I]: [wherein R represents a hydrogen atom, a non-substituted or substituted aromatic ring, or a straight or branched alkyl group having 1 to 20 carbon(s) which may have a cyclic moiety optionally substituted with at least one substituent (halogen atom, hydroxyl group, straight or branched alkoxy group having 1 to 10 carbon(s) which may have a cyclic moiety, non-substituted or substituted aromatic group)].Type: ApplicationFiled: March 24, 2004Publication date: August 17, 2006Inventors: Kenji Tokuhisa, Hideyuki Mimura, Kosuke Kawada, Shoji Arai
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Patent number: 7019162Abstract: A process for producing a 2-fluoro-3-oxoalkylcarboxylic acid ester by fluorinating 3-oxoalkylcarboxylic acid ester with a fluorine gas is provided. The process is characterized in that the concentration of 3-oxoalkylcarboxylic acid ester in the reaction mixture for fluorination is maintained at 3 wt % or higher. Also provided is a process for purifying 2-fluoro-3-oxoalkylcarboxylic acid ester characterized in that 2-fluoro-3-oxoalkylcarboxylic acid ester is produced at high yield and with less impurities by washing fluorinated 3-oxoalkylcarboxylic acid ester with 3 or more times as much water as the amount of reaction mixture. According to the processes of the present invention, not only is the generation of unwanted by-products minimized, but fluorinated 3-oxoalkylcarboxylic acid ester can be purified in an efficient manner.Type: GrantFiled: December 25, 2001Date of Patent: March 28, 2006Assignee: Tosoh F-Tech, Inc.Inventors: Norihisa Kondo, Hideyuki Mimura, Kazunori Nukui, Kosuke Kawada, Shoji Arai
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Patent number: 6894197Abstract: A method for producing fluorinated alcohols from fluorinated alkyl halides can produce fluorinated alcohols at high product yield and at high selectivity in a single-step reaction. The method eliminates the need to use heavy metals and other toxic compounds that are difficult to handle or process. Specifically, the method produces a fluorinated alcohol represented by the following general formula (2): Rf(A)OH??(2) wherein Rf represents a perfluoroalkyl group having 1 to 10 carbon atoms; and A represents a straight-chained or branched saturated hydrocarbon group having 3 to 10 carbon atoms. The method is characterized in that it allows a fluorinated alkyl halide represented by the following general formula (1) to react with an alkali metal salt of 4-hydroxybutyrate in a gamma-butyrolactone solvent: Rf(A)X??(1) wherein Rf and A are as defined above; and X represents a halogen atom.Type: GrantFiled: July 1, 2002Date of Patent: May 17, 2005Assignee: Tosoh F-Tech, Inc.Inventors: Hideyuki Mimura, Kosuke Kawada, Shoji Arai
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Publication number: 20040249190Abstract: The present invention concerns a method for purifying/separating a 2-fluoro-3-oxoalkylcarboxylic acid ester from a reaction mixture resulting from the fluorination of a 3-oxoalkylcarboxylic acid ester. The method involves depleting the reaction mixture of a hydrogen fluoride byproduct; and subsequently, separating the 2-fluoro-3-oxoalkylcarboxylic acid ester by distillation. The 2-fluoro-3-oxoalkylcarboxylic acid ester obtained by the method of the invention is highly pure and is thus suitable for use as an intermediate for the production of pharmacological products or agricultural chemicals.Type: ApplicationFiled: March 24, 2004Publication date: December 9, 2004Inventors: Norihisa Kondo, Hideyuki Mimura, Kosuke Kawada, Shoji Arai
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Publication number: 20040152926Abstract: A method for producing fluorinated alcohols from fluorinated alkyl halides can produce fluorinated alcohols at high product yield and at high selectivity in a single-step reaction. The method eliminates the need to use heavy metals and other toxic compounds that are difficult to handle or process.Type: ApplicationFiled: March 1, 2004Publication date: August 5, 2004Inventors: Hideyuki Mimura, Kosuke Kawada, Shoji Arai
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Publication number: 20040054217Abstract: A process for producing a 2-fluoro-3-oxoalkylcarboxylic acid ester by fluorinating 3-oxoalkylcarboxylic acid ester with a fluorine gas is provided. The process is characterized in that the concentration of 3-oxoalkylcarboxylic acid ester in the reaction mixture for fluorination is maintained at 3 wt % or higher. Also provided is a process for purifying 2-fluoro-3-oxoalkylcarboxylic acid ester characterized in that 2-fluoro-3-oxoalkylcarboxylic acid ester is produced at high yield and with less impurities by washing fluorinated 3-oxoalkylcarboxylic acid ester with 3 or more times as much water as the amount of reaction mixture. According to the processes of the present invention, not only is the generation of unwanted by-products minimized, but fluorinated 3-oxoalkylcarboxylic acid ester can be purified in an efficient manner.Type: ApplicationFiled: June 26, 2003Publication date: March 18, 2004Inventors: Norihisa Kondo, Hideyuki Mimura, Kazunori Nukui, Kosuke Kawada, Shoji Arai
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Patent number: 5501262Abstract: A cord locking assembly mounted in the blind head box or the blind hand grip axially movably fitted on the hollow pole suspended from the blind head box.The assembly comprises a movable plug, a fixed plug hole sleeve for fitting engagement with the plug, a lock compression spring to bias the plug to the plug hole sleeve, lift cords passing through the plug hole sleeve, and means for loosening the lock compression spring. The means is the hand grip in the case of the assembly mounted the hand grip. The means is a knob or pull cord fixed to a holder in which the lock compression spring is mounted in the case the assembly mounted in the blind head box.Type: GrantFiled: October 28, 1994Date of Patent: March 26, 1996Assignee: Toso Co., Ltd.Inventors: Tadashi Inaba, Toshiyuki Mori, Masahiro Nagashima, Kosuke Kawada
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Patent number: 4996320Abstract: A pyridine-compound is reacted with fluorine together with a Bronsted acid-compound or Lewis acid to form a N-fluoropyridinium salt which is very active to other compounds but is very selective for the preparation of a desired product and this product is very useful for a fluorine-introducing agent which makes it useful for the preparation of fluoro-compounds such as thyroid inhibitor.Type: GrantFiled: January 9, 1989Date of Patent: February 26, 1991Assignee: Sagami Chemical Research CenterInventors: Teruo Umemoto, Kyoichi Tomita, Kosuke Kawada, Ginjiro Tomizawa
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Patent number: RE35177Abstract: A pyridine-compound is reacted with fluorine together with a .[.Bronsted.]. .Iadd.Bronsted .Iaddend.acid-compound or Lewis acid to form a N-fluoropyridinium salt which is very active to other compounds but is very selective for the preparation of a desired product and this product is very useful for a fluorine-introducing agent which makes it useful for the preparation of fluoro-compounds such as thyroid inhibitor.Type: GrantFiled: February 17, 1994Date of Patent: March 12, 1996Assignees: Sagami Chemical Research Center, Chichibu Onoda Cement CorporationInventors: Teruo Umemoto, Kyoichi Tomita, Kosuke Kawada, Ginjiro Tomizawa