Patents by Inventor Kosuke NAGAE
Kosuke NAGAE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11408817Abstract: The detection system according to the present invention has a detection chip, a light source, and a detection unit. The detection chip has a housing that has an opening at an upper portion, and a reaction field for trapping a substance to be detected, the reaction field being arranged on an inner surface of the side walls included in the housing. The light source irradiates the detection chip with light from the outside such that evanescent light or surface plasmon resonance is generated under the reaction field. The detection unit detects light which is emitted from the detection chip when the light source irradiates the detection chip with light, and the amount of which changes depending on the amount of the substance to be detected trapped in the reaction field.Type: GrantFiled: July 24, 2017Date of Patent: August 9, 2022Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Tomonori Kaneko, Kosuke Nagae, Takatoshi Kaya, Yukito Nakamura
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Patent number: 11215613Abstract: This detection device has a holder and a heating unit. The holder holds a detection chip that has the following: a prism that has an incidence surface and a film-formation surface; a metal film formed on said film-formation surface; trapping bodies laid out on the surface of said metal film; and a substrate that is laid out on the surface of the metal film, and together with the metal film, forms a liquid collection section in which a liquid is collected. The heating unit heats at least one of the substrate, the prism, and the metal film either while in contact therewith or without contacting same. Also, the heating unit is positioned so as to avoid the path that excitation light takes from an excitation-light emission unit to the abovementioned incidence surface.Type: GrantFiled: October 31, 2014Date of Patent: January 4, 2022Assignee: KONICA MINOLTA, INC.Inventors: Kosuke Nagae, Hiroshi Hirayama
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Publication number: 20210356386Abstract: The detection system according to the present invention has a detection chip, a light source, and a detection unit. The detection chip has a housing that has an opening at an upper portion, and a reaction field for trapping a substance to be detected, the reaction field being arranged on an inner surface of the side walls included in the housing. The light source irradiates the detection chip with light from the outside such that evanescent light or surface plasmon resonance is generated under the reaction field. The detection unit detects light which is emitted from the detection chip when the light source irradiates the detection chip with light, and the amount of which changes depending on the amount of the substance to be detected trapped in the reaction field.Type: ApplicationFiled: July 24, 2017Publication date: November 18, 2021Inventors: Tomonori KANEKO, Kosuke Nagae, Takatoshi Kaya, Yukito Nakamura
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Patent number: 10976250Abstract: Provided is a position detection method and a position detection device for detecting a position of a sensor chip and obtaining relative positional information between a well member and a prism as for a well chip type sensor chip in which the well member is provided on a prism. By applying measurement light to the sensor chip while changing a distance between the sensor chip and a measurement light irradiation unit and detecting reflected light traveling in a predetermined direction out of the reflected light generated when the measurement light is reflected by the sensor chip, at least any one of the position of the sensor chip and the relative position between a dielectric member and a sample solution holding member is detected on the basis of a change in intensity of the detected reflected light.Type: GrantFiled: January 16, 2018Date of Patent: April 13, 2021Assignee: KONICA MINOLTA, INC.Inventors: Yukito Nakamura, Takatoshi Kaya, Kosuke Nagae
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Publication number: 20200256796Abstract: A first frame having a first through-hole is arranged on a support so that one opening of the first through-hole is closed. A liquid containing a capturer for capturing a substance to be detected is fed into the first through-hole, and the capturer is immobilized on the support exposed in the first through-hole. After removing the liquid from the support, a second frame having the second through-hole is arranged on the support in the first through-hole so that one opening of the second through-hole is closed.Type: ApplicationFiled: April 28, 2020Publication date: August 13, 2020Applicant: KONICA MINOLTA, INC.Inventors: Yukito NAKAMURA, Takatoshi KAYA, Tomonori KANEKO, Kosuke NAGAE, Hiroshi HIRAYAMA
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Patent number: 10690596Abstract: The surface plasmon-enhanced fluorescence measurement device has: a light source that irradiates the diffraction grating with a linearly polarized excitation light; a rotating part that changes the direction of the optical axis of the excitation light with respect to the diffraction grating when seen in plan view, or changes the polarization direction of the excitation light with respect to the diffraction grating; a polarizer that extracts linearly polarized light from the fluorescence emitted from the fluorescent substance; and a light detection unit that detects the linearly polarized light extracted by the polarizer.Type: GrantFiled: December 1, 2015Date of Patent: June 23, 2020Assignee: Konica Minolta, Inc.Inventors: Yukito Nakamura, Kosuke Nagae, Takatoshi Kaya
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Patent number: 10677731Abstract: A first frame having a first through-hole is arranged on a support so that one opening of the first through-hole is closed. A liquid containing a capturer is fed into the first through-hole, and a capturer is immobilized on the support exposed in the first through-hole. After removing the liquid from the support, a second frame having the second through-hole is arranged on the support in the first through-hole so that one opening of the second through-hole is closed.Type: GrantFiled: April 5, 2016Date of Patent: June 9, 2020Assignee: KONICA MINOLTA, INC.Inventors: Yukito Nakamura, Takatoshi Kaya, Tomonori Kaneko, Kosuke Nagae, Hiroshi Hirayama
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Patent number: 10495575Abstract: The present invention pertains to a surface plasmon enhanced fluorescence analysis device and a surface plasmon enhanced fluorescence measurement method which use GC-SPFS and make it possible to detect a substance to be detected with high sensitivity. This surface plasmon enhanced fluorescence measurement device has: a light source for irradiating the diffraction grating of a chip with excited light; a polarizer for removing linearly polarized light from fluorescent light emitted from a fluorescent substance on the diffraction grating; and a photodetector for detecting the linearly polarized light removed by the polarizer.Type: GrantFiled: April 8, 2014Date of Patent: December 3, 2019Assignee: KONICA MINOLTA, INC.Inventors: Yukito Nakamura, Takatoshi Kaya, Kosuke Nagae, Akitoshi Nozaki, Fumio Nagai, Ryouta Ishikawa, Akiyuki Namatame
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Publication number: 20190360934Abstract: Provided is a position detection method and a position detection device for detecting a position of a sensor chip and obtaining relative positional information between a well member and a prism as for a well chip type sensor chip in which the well member is provided on a prism. By applying measurement light to the sensor chip while changing a distance between the sensor chip and a measurement light irradiation unit and detecting reflected light traveling in a predetermined direction out of the reflected light generated when the measurement light is reflected by the sensor chip, at least any one of the position of the sensor chip and the relative position between a dielectric member and a sample solution holding member is detected on the basis of a change in intensity of the detected reflected light.Type: ApplicationFiled: January 16, 2018Publication date: November 28, 2019Inventors: Yukito NAKAMURA, Takatoshi KAYA, Kosuke NAGAE
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Patent number: 10254228Abstract: The detection chip according to the present invention has an accommodating part, a metal film, a first reaction field, and a second reaction field. The accommodating part accommodates a liquid. The metal film is arranged in a bottom part of the accommodating part so that one face thereof faces into the accommodating part. The first reaction field and the second reaction field are arranged in mutually different regions on one face of the metal film. A capture body is immobilized in the first reaction field and the second reaction field. When the liquid is accommodated in the accommodating part, the depth of the liquid on the first reaction field differs from the depth of the liquid on the second reaction field.Type: GrantFiled: November 20, 2015Date of Patent: April 9, 2019Assignee: Konica Minolta, Inc.Inventors: Kosuke Nagae, Takatoshi Kaya, Yukito Nakamura
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Publication number: 20180266954Abstract: The detection chip according to the present invention has an accommodating part, a metal film, a first reaction field, and a second reaction field. The accommodating part accommodates a liquid. The metal film is arranged in a bottom part of the accommodating part so that one face thereof faces into the accommodating part. The first reaction field and the second reaction field are arranged in mutually different regions on one face of the metal film. A capture body is immobilized in the first reaction field and the second reaction field. When the liquid is accommodated in the accommodating part, the depth of the liquid on the first reaction field differs from the depth of the liquid on the second reaction field.Type: ApplicationFiled: November 20, 2015Publication date: September 20, 2018Applicant: Konica Minolta, Inc.Inventors: Kosuke Nagae, Takatoshi Kaya, Yukito Nakamura
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Publication number: 20180080872Abstract: A first frame having a first through-hole is arranged on a support so that one opening of the first through-hole is closed. A liquid containing a capturer is fed into the first through-hole, and a capturer is immobilized on the support exposed in the first through-hole. After removing the liquid from the support, a second frame having the second through-hole is arranged on the support in the first through-hole so that one opening of the second through-hole is closed.Type: ApplicationFiled: April 5, 2016Publication date: March 22, 2018Applicant: KONICA MINOLTA, INC.Inventors: Yukito NAKAMURA, Takatoshi KAYA, Tomonori KANEKO, Kosuke NAGAE, Hiroshi HIRAYAMA
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Publication number: 20180017493Abstract: The surface plasmon-enhanced fluorescence measurement device has: a light source that irradiates the diffraction grating with a linearly polarized excitation light; a rotating part that changes the direction of the optical axis of the excitation light with respect to the diffraction grating when seen in plan view, or changes the polarization direction of the excitation light with respect to the diffraction grating; a polarizer that extracts linearly polarized light from the fluorescence emitted from the fluorescent substance; and a light detection unit that detects the linearly polarized light extracted by the polarizer.Type: ApplicationFiled: December 1, 2015Publication date: January 18, 2018Applicant: Konica Minolta, Inc.Inventors: Yukito Nakamura, Kosuke Nagae, Takatoshi Kaya
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Publication number: 20170030833Abstract: The present invention pertains to a surface plasmon enhanced fluorescence analysis device and a surface plasmon enhanced fluorescence measurement method which use GC-SPFS and make it possible to detect a substance to be detected with high sensitivity. This surface plasmon enhanced fluorescence measurement device has: a light source for irradiating the diffraction grating of a chip with excited light; a polarizer for removing linearly polarized light from fluorescent light emitted from a fluorescent substance on the diffraction grating; and a photodetector for detecting the linearly polarized light removed by the polarizer.Type: ApplicationFiled: April 8, 2014Publication date: February 2, 2017Inventors: Yukito NAKAMURA, Takatoshi KAYA, Kosuke NAGAE, Akitoshi NOZAKI, Fumio NAGAI, Ryouta ISHIKAWA, Akiyuki NAMATAME
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Publication number: 20160266111Abstract: This detection device has a holder and a heating unit. The holder holds a detection chip that has the following: a prism that has an incidence surface and a film-formation surface; a metal film formed on said film-formation surface; trapping bodies laid out on the surface of said metal film; and a substrate that is laid out on the surface of the metal film, and together with the metal film, forms a liquid collection section in which a liquid is collected. The heating unit heats at least one of the substrate, the prism, and the metal film either while in contact therewith or without contacting same. Also, the heating unit is positioned so as to avoid the path that excitation light takes from an excitation-light emission unit to the abovementioned incidence surface.Type: ApplicationFiled: October 31, 2014Publication date: September 15, 2016Inventors: Kosuke NAGAE, Hiroshi HIRAYAMA