Abstract: Provided is a therapeutic agent for cellular drug resistance to a microtubule inhibitor. The therapeutic agent contains a ? opioid receptor agonist.

Abstract: A pulse rate counter that can accurately measure pulse rate regardless of whether the user is resting or exercising is disclosed. In the pulse rate counter, a pulse wave component extraction means extracts pulse wave components based on the frequency analysis results of a first calculation means and a second calculation means. During this process, an extraction method switching means determines whether the user is resting or exercising based on the amplitude level of the signal output of a body movement signal conversion means, the level (power) of the frequency spectrum of the output signal of the second calculation means, or the degree of variation in the level. If the user is determined to be resting, the extraction method switching means causes the pulse wave component extraction means to extract the pulse wave components based on the frequency analysis result of the first calculation means.