Abstract: A peptide which comprises a tryptophan triplet, is between 10 and 34 amino acid residues in length and exhibits antimicrobial activity is provided, together with pharmaceutical and non-pharmaceutical compositions containing, and methods utilizing, such peptides.

Abstract: Provided are methods for maintaining or enhancing the antimicrobial activity of antimicrobial peptides, lytic peptides, and peptide-derived antibiotics by the use of metal ions. Also provided are pharmaceutical and other compositions comprising such peptides and/or at least one metal ion. Also provided are therapeutic and other methods for controlling the growth of undesirable or pathogenic microorganisms in various loci or milieu in, on, or outside the body employing these peptides and metal ions. Also provided are kits comprising containers containing a peptide and a metal ion(s), respectively.

Abstract: Peptides exhibiting antibacterial and/or antifungal activity are provided which comprise a tryptophan triplet and are between 10-34 amino acid residues in length. Pharmaceutical and non-pharmaceutical compositions containing the peptides, as well as methods of using the peptides as antimicrobials are also disclosed.